3031102-94-7
Chemical Structure
TRAP1-IN-1
- CAS No.: 3031102-94-7
- Formula:C45H39F7N2O4P2
- Molecular Weight:866.74
InChIKey: ZKAOHTPZPRTYPO-UHFFFAOYSA-O
SMILES: O=C(C1=C(O)C=CC(C(N2CC(C(F)=CC=C3)=C3C2)=O)=C1)N(C4)CC5=C4C=CC(OCCC[P+](C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8)=C5.F[P-](F)(F)(F)(F)F
Biological Activity: TRAP1-IN-1 (compound 35) is a potent and selective inhibitor of TRAP1，a mitochondrial isoform of Hsp90. TRAP1-IN-1 has >250-fold TRAP1 selectivity over Grp94，and disrupts TRAP1 tetramer stability，induces TRAP1 client protein degradation. TRAP1-IN-1 also inhibits mitochondrial complex I of oxidative phosphorylation OXPHOS，disrupts the mitochondrial membrane potential，and enhances glycolysis metabolism[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TRAP1-IN-1 | 96.03% | TRAP1-IN-1 (compound 35) is a potent and selective inhibitor of TRAP1，a mitochondrial isoform of Hsp90. TRAP1-IN-1 has >250-fold TRAP1 selectivity over Grp94，and disrupts TRAP1 tetramer stability，induces TRAP1 client protein degradation. TRAP1-IN-1 also inhibits mitochondrial complex I of oxidative phosphorylation OXPHOS，disrupts the mitochondrial membrane potential，and enhances glycolysis metabolism. | ||||||||||||||||||||
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Keywords
