Fumarate hydratase/FH Protein, Human

The fumarate hydratase/FH protein plays a key role in cellular processes as it catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle, which is essential for energy production through the production of NADH . Fumarate hydratase/FH Protein, Human is the recombinant human-derived Fumarate hydratase/FH protein, expressed by E. coli , with tag free.

Fumarate Hydratase (FH) is an enzyme that catalyzes the reversible conversion of fumarate to L-malate. This stereospecific interconversion plays a pivotal role in the tricarboxylic acid (TCA) cycle, a central metabolic pathway involved in energy production. Specifically, FH facilitates the hydration of fumarate to L-malate, contributing to a key transition step in the TCA cycle. Experiments in various species suggest that specific isoforms of FH may act in defined pathways and exhibit preferences for one direction of the reaction over the other. By participating in the TCA cycle, FH ensures the efficient generation of energy in the form of NADH, highlighting its essential role in cellular metabolism.

Human

E. coli

Tag Free

P07954-1 (A45-K510)

2271  [NCBI]

Full Length of Isoform-1 Mature Protein

ASQNSFRIEYDTFGELKVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYGLDPKIANAIMKAADEVAEGKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHPNDHVNKSQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAVPLTLGQEFSGYVQQVKYAMTRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKPKDMLGPK

Approximately 45 kDa, based on SDS-PAGE under reducing conditions.

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  ≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.