FH - fumarate hydratase Gene

Also Known as MCL; FMRD; HsFH; LRCC; HLRCC; MCUL1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2271

About FH

Cytogenetic location: 1q43 Genomic coordinates (GRCh38): 1:241,497,603-241,519,755 (from NCBI)

This gene has 8 transcripts (splice variants), 221 orthologues, 2 paralogues and is associated with 75 phenotypes. Ubiquitous expression in heart (RPKM 49.3), liver (RPKM 41.8) and 25 other tissues.

Summary

The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy. [provided by RefSeq, Jul 2008]

FH Products (1)

mRNA	Protein	Name
NM_000143.4	NP_000134.2	fumarate hydratase, mitochondrial

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables fumarate hydratase activity	IDA IDA: Inferred from direct assay	26237645	GOA
enables fumarate hydratase activity	IMP IMP: Inferred from mutant phenotype	29456767	GOA
enables histone binding	IPI IPI: Inferred from physical interaction	26237645	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	20231875	GOA
involved in fumarate metabolic process	IDA IDA: Inferred from direct assay	26237645	GOA
involved in malate metabolic process	IDA IDA: Inferred from direct assay	30761759	GOA
involved in positive regulation of double-strand break repair via nonhomologous end joining	IDA IDA: Inferred from direct assay	26237645	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	27037871	GOA
located in cytosol	IDA IDA: Inferred from direct assay	20231875	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	27037871	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20231875	GOA
located in site of double-strand break	IDA IDA: Inferred from direct assay	26237645	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FH Protein Structure

Lyase_1

FumaraseC_C

0
100
200
300
400
510 a.a.

Protein Preferred Names	Protein Names
fumarate hydratase, mitochondrial	epididymis secretory sperm binding protein

FH Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FH	P07954	CCDC102B	Homo sapiens	Q68D86	Validated Y2H	32296183
Intra	FH	P07954	CCDC57	Homo sapiens	Q2TAC2-2	Validated Y2H	32296183
Intra	FH	P07954	H2AZ1	Homo sapiens	P0C0S5	Anti Bait CoIP	26237645
Intra	FH	P07954	H2AZ1	Homo sapiens	P0C0S5	Pull Down	26237645
Intra	FH	P07954	H2AZ1	Homo sapiens	P0C0S5	Anti Tag CoIP	26237645
Intra	FH	P07954	DGCR6	Homo sapiens	Q14129	Validated Y2H	32296183
Intra	FH	P07954	CSTPP1	Homo sapiens	Q9H6J7-2	Validated Y2H	32296183
Intra	FH	P07954	LMNB2	Homo sapiens	Q03252	Validated Y2H	32296183
Intra	FH	P07954	EXOSC5	Homo sapiens	Q9NQT4	Validated Y2H	32296183
Intra	FH	P07954	KLHL6	Homo sapiens	Q8WZ60	Validated Y2H	32296183
Intra	FH	P07954	PIM1	Homo sapiens	P11309	Y2H Array	25416956
Intra	FH	P07954	SAT1	Homo sapiens	P21673	Validated Y2H	32296183
Intra	FH	P07954	TTC19	Homo sapiens	Q6DKK2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FH Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70267	Fumarate hydratase/FH Protein, Human	P07954-1 (A45-K510)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73062	Fumarate Hydratase/FH Protein, Human (His)	P07954-1 (A45-K510)	≥ 95%, as determined by reducing SDS-PAGE.

FH Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80672	FH Antibody (YA763)	WB, ICC/IF	Human, Mouse, Rat
HY-P80672A	FH Antibody (YA763)(PBS only)	WB, ICC/IF	Human, Mouse, Rat
HY-P85661	FH Antibody (YA5353)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Fumarase Deficiency	Fumaric Aciduria FMRD Fumarate Hydratase Deficiency Deficiency, Fumarase
Hereditary Leiomyomatosis And Renal Cell Cancer	HLRCC Lrcc Mcl Multiple Cutaneous And Uterine Leiomyomata Leiomyomatosis And Renal Cell Cancer Mcul Mcul1 Familial Leiomyomatosis And Renal Cell Cancer Familial Leiomyomatosis Cutis Et Uteri Familial Leiomyomatosis With Renal Carcinoma Familial Multiple Cutaneous Leiomyomas Reed'S Syndrome Multiple Cutaneous And Uterine Leiomyomata 1, With Or Without Renal Cell Carcinoma Leiomyomatosis And Renal Cell Cancer, Hereditary Leiomyoma, Multiple Cutaneous Multiple Cutaneous Leiomyomata Hereditary Leiomyomatosis And Renal Cell Carcinoma Multiple Cutaneous Leiomyoma Hereditary Leiomyomatosis Hereditary Leiomyomatosis With Renal Carcinoma Hereditary Multiple Cutaneous Leiomyomas Multiple Cutaneous And Uterine Leiomyomas Reed Syndrome Leiomyoma Multiple Cutaneous Leiomyomatosis And Renal Cell Cancer Hereditary Multiple Cutaneous And Uterine Leiomyomata 1 With Or Without Renal Cell Carcinoma
Fumarate Hydratase Deficiency	Fumarase Deficiency Fumaric Aciduria
Fh Tumor Predisposition Syndrome	Hereditary Leiomyomatosis Renal Cell Cancer Hlrcc Multiple Cutaneous Uterine Leiomyomatosis Mcl/Mcul Reed'S Syndrome Multiple Cutaneous And Uterine Leiomyomatosis
Hereditary Paraganglioma-Pheochromocytoma Syndromes	Hereditary Pheochromocytoma-Paraganglioma Hereditary Paraganglioma-Pheochromocytoma Familial Pheochromocytoma-Paraganglioma Paragangliomas 2 Paragangliomas 3 Paragangliomas 4 Sdhx-Related Paraganglioma-Pheochromocytoma Familial Paraganglioma Syndrome Familial Paraganglioma-Pheochromocytoma Syndromes Fpgl Fpgl/Pheo Paragangliomas 1 Paraganglioma
Bap1 Tumor Predisposition Syndrome	Bap1-Related Tumor Predisposition Syndrome Common Syndrome Bap1 Cancer Syndrome Bap1-Tpds Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, And Other Internal Neoplasms Tumor Predisposition Syndrome Tumor Susceptibility Linked To Germline Bap1 Mutations Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, Other Internal Neoplasms Tumor Predisposition
Inherited Cancer-Predisposing Syndrome	Hereditary Cancer-Predisposing Syndrome
Leiomyoma Cutis	Cutaneous Leiomyoma Leiomyoma Of The Skin
Leiomyomatosis
Leiomyoma	Leiomyomatous Neoplasm Leiomyomatous Tumor Leiomyomas Fibroid Tumor Uterine Fibroids
Dermis Tumor	Dermis Tumour Neoplasm Of Dermis Tumor Of Dermis Tumour Of Dermis
Leiomyoma, Uterine	Uterine Leiomyoma Uterine Fibroid Uterine Fibroids Plexiform Leiomyoma UL Leiomyoma Of Corpus Uteri Uterus Fibroma
Encephalopathy	Brain Diseases Encephalopathies Toxic Encephalopathy Toxic Brain Fever Toxic Brain Inflammation Toxic Brain Stem Inflammation Toxic Cerebral Fever Toxic Cerebrospinal Fever Toxic Cerebrospinal Inflammation Encephalopathy Nec Encephalopathy Nos Encephalopathy Disease Encephalopathy Syndrome
Paraganglioma	Chemodectoma Glomus Body Tumor Paragangliomas Carotid Body Paraganglioma Extra-Adrenal Paraganglioma
Uterus Leiomyosarcoma	Leiomyosarcoma Of Uterus Leiomyosarcoma Of Corpus Uteri Leiomyosarcoma Of The Corpus Uteri Uterine Leiomyosarcoma
Myoma	Muscle Benign Neoplasm Myomatous Neoplasm Neoplasms, Muscle Tissue Benign Neoplasm Of The Muscle Muscle Neoplasm Muscle Tissue Neoplasm Myomatous Tumor Neoplasm Of Muscle Muscle Neoplasms Myomas
Dartoic Leiomyoma	Dartoic Myoma
Breast Leiomyoma
Leiomyosarcoma	Leiomyosarcomas
Familial Renal Papillary Carcinoma	Hereditary Papillary Renal Carcinoma Papillary Renal Cancer Hereditary
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Hereditary Renal Cell Carcinoma
Kidney Cancer	Renal Cancer Renal Carcinoma Kidney Neoplasm Malignant Neoplasm Of Kidney Except Pelvis Malignant Tumour Of Kidney Kidney Neoplasms Cancer, Kidney Cancer, Renal Malignant Neoplasm Of Kidney Renal Cell Carcinoma
Uterine Benign Neoplasm
Bizarre Leiomyoma	Atypical Leiomyoma Pleomorphic Leiomyoma Symplastic Leiomyoma
Reproductive Organ Benign Neoplasm
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Hemolytic Anemia	Anemia, Hemolytic Anemia Hemolytic Anaemia Due To Other Disorders Of Glutathione Metabolism Chronic Non Spherocytic Anaemia G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia Favism Anaemia Haemolytic Anaemia Due Tog6pd Deficiency Favism Pentose Phosphate Pathway Disorder Anaemia Anaemia Due To Pentose Phosphate Pathway Defect
Birt-Hogg-Dube Syndrome	Hornstein-Knickenberg Syndrome Fibrofolliculomas With Trichodiscomas And Acrochordons BHD Birt-Hogg-Dubé Syndrome Multiple Fibrofolliculoma Familial Bhd Syndrome Birt Hogg Dube Syndrome Hornstein-Birt-Hogg-Dubé Syndrome Multiple Fibrofolliculomas
Breast Leiomyosarcoma	Leiomyosarcoma Of The Breast
Oncocytoma	Oxyphilic Adenoma Follicular Adenoma, Oxyphilic Cell Adenoma, Oxyphilic Hurthle Cell Tumor Oncocytic Neoplasm
Mitochondrial Encephalomyopathy	Mitochondrial Encephalomyopathies Encephalomyopathy, Mitochondrial
Cystic Kidney Disease	Renal Cyst Simple Renal Cyst Kidney Cysts Kidney Diseases, Cystic Renal Cysts Kidney Cyst Cystic Kidney Congenital Cystic Kidney Disease Cystic Kidney Diseases Bosniak 1 Cyst
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Colon Leiomyoma	Colonic Leiomyoma
Collecting Duct Carcinoma	Kidney Medullary Carcinoma Renal Medullary Carcinoma Bdc Bellini Carcinoma Bellini Duct Carcinoma Cdc Collecting Duct Carcinoma Of The Kidney Renal Cell Adenocarcinoma Carcinoma Of Renal Collecting Duct Renal Carcinoma, Collecting Duct Type Renal Cell Carcinoma Bellini'S Duct Carcinoma Renal Collecting Duct Carcinoma Adenocarcinoma Of Kidney
Hypotonia
Renal Oncocytoma	Oncocytoma, Renal Oncocytoma Of Kidney Renal Epithelial Oncocytic Tumor Oncocytoma Kidney Oncocytoma Renal Kidney Oncocytoma
Metabolic Acidosis
Persistent Generalized Lymphadenopathy	Pgl Persistant Generalized Lymphadenopathy
Paraganglioma And Gastric Stromal Sarcoma	Carney-Stratakis Syndrome Paraganglioma And Gastrointestinal Stromal Tumor Carney Dyad Carney-Stratakis Dyad Of Paraganglioma And Gastric Stromal Sarcoma Paraganglioma And Gist Carney-Stratakis Dyad Gist-Paraganglioma Dyad PGGSS Paraganglioma, Gastric Stromal Sarcoma Gastrointestinal Stromal Tumors
Cardiomyopathy, Dilated, 1gg	Dilated Cardiomyopathy 1gg CMD1GG Cardiomyopathy, Dilated 1gg Cardiomyopathy, Dilated, Type 1gg
Mucinous Ovarian Cystadenoma	Mucinous Cystadenoma Of Ovary Ovarian Mucinous Cystadenoma
Acth-Independent Macronodular Adrenal Hyperplasia	Acth-Independent Macronodular Adrenocortical Hyperplasia Adrenocorticotropic Hormone-Independent Macronodular Adrenal Hyperplasia Corticotropin-Independent Macronodular Adrenal Hyperplasia Cushing Syndrome Due To Macronodular Adrenal Hyperplasia AIMAH1 Aimah Massive Macronodular Adrenocortical Disease Mmad Primary Macronodular Adrenal Hyperplasia Cushing Syndrome, Adrenal, Due To Aimah Primary Bilateral Macronodular Adrenal Hyperplasia Acth-Independent Macronodular Adrenal Hyperplasia 1 Acth-Independent Cushing Syndrome Adrenal Cushing Syndrome Due To Aimah Acth-Independent Macronodular Adrenal Hyperplasia 2
Cutaneous Leiomyosarcoma	Leiomyosarcoma Of The Skin
Renal Cell Carcinoma, Papillary, 1	Papillary Renal Cell Carcinoma Hereditary Papillary Renal Cell Carcinoma Papillary Renal Cell Carcinoma, Sporadic Papillary Renal Cell Adenocarcinoma RCCP RCCP1 Renal Cell Carcinoma, Papillary Renal Cell Carcinoma, Papillary, 1, Familial And Somatic Chromophil Carcinoma Of Kidney Papillary Kidney Carcinoma Sporadic Papillary Renal Cell Carcinoma Chromophil Renal Cell Carcinoma Papillary Renal Carcinoma, Malignant - Papillary Renal Cell Carcinoma, Bilateral - Papillary Renal Cell Carcinoma, Familial - Papillary Renal Cell Carcinoma, Multiple - Papillary Renal Cell Carcinoma, Sporadic - Renal Adenocarcinoma Chromophil Rcc Hprcc Renal Cell Carcinoma Papillary Chromophilic Renal Cell Carcinoma Prcc Carcinoma, Renal Cell, Papillary, Type 1 Type 1 Papillary Renal Cell Carcinoma Renal Cell Carcinoma Hereditary Papillary Renal Carcinoma
Polyhydramnios
Kidney Benign Neoplasm	Renal And Ureteral Tumor Benign Kidney Neoplasm
Endocrine Organ Benign Neoplasm
Multiple Enchondromatosis, Maffucci Type	Maffucci Syndrome Chondrodysplasia With Hemangioma Chondroplasia Angiomatosis Enchondromatosis With Hemangiomata Hemangiomatosis Chondrodystrophica Kast Syndrome Multiple Angiomas And Endochondromas Dyschondrodysplasia With Hemangiomas Enchondromatosis Type Ii Enchondromatosis With Multiple Cavernous Hemangiomas Dyschondroplasia And Cavernous Hemangioma Hemangiomata With Dyschondroplasia
Giant Axonal Neuropathy 1, Autosomal Recessive	Giant Axonal Neuropathy Giant Axonal Neuropathy 1 Gan GAN1 Giant Axonal Neuropathy-1 Neuropathy, Giant Axonal Giant Axonal Disease Neuropathy, Axonal, Giant, Type 1
Primary Pigmented Nodular Adrenocortical Disease	Ppnad Primary Pigmented Nodular Adrenal Dysplasia Pigmented Nodular Adrenocortical Disease, Primary, 2 Pigmented Nodular Adrenocortical Disease, Primary, 1
Von Hippel-Lindau Syndrome	Von Hippel-Lindau Disease Vhl Vhl Syndrome VHLS Von Hippel-Lindau Syndrome, Modifier Of Hippel Lindau Syndrome Angiomatosis Retinae Cerebelloretinal Angiomatosis, Familial Hippel-Lindau Disease Familial Cerebelloretinal Angiomatosis Lindau Disease VHLD
Chromophobe Renal Cell Carcinoma	Chromophobe Adenocarcinoma Chromophobe Carcinoma Of Kidney Kidney Chromophobe Renal Cell Carcinoma, Chromophobe Cell Crcc Chrcc Chromophobe Renal Cell Adenocarcinoma Chromophobe Renal Carcinoma Chromophobe Carcinoma
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
West Syndrome	Infantile Spasms Infantile Spasms Syndrome Infantile Spasm X-Linked Infantile Spasm Syndrome X-Linked Infantile Spasms Epileptic Encephalopathy, Early Infantile, 1 Is Tonic Spasms With Clustering, Arrest Of Psychomotor Development And Hypsarrhythmia On Eeg West'S Syndrome Spasms, Infantile Is -[Infantile Spasm] Salaam Spasm Salaam Tic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-34350	2-(Aminomethyl)phenol	Inhibitor	99.45%	Phase 2
HY-N0842	Bevirimat	Inhibitor	99.82%	Phase 2
HY-12346	FH1	Inhibitor	99.17%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991067	Vensobafusp alfa	Inhibitor	97%	Phase 2

Pre-clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15721	FH535	Inhibitor	99.95%	Unkown
HY-144896	FHT-1015	Inhibitor	98.41%	Unkown
HY-D0917	NIR-Red Dead Cell-1 Dye		≥96.0%	Unkown
HY-150686	Chitin synthase inhibitor 4	Inhibitor	98.97%	Unkown
HY-RS07575	LDLR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-160875	GST-FH.1	Inhibitor	90.0%	Unkown
HY-E70062	α-2,3-Sialyltransferase, pasteurella multocida		/	Unkown
HY-W028210	O-Phthalimide-C5-acid		98.0%	Unkown
HY-N8378	Clonostachydiol		/	Unkown
HY-P2969	Complement factor I		93.00%	Unkown
HY-RS02561	CFH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04930	FH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-160874	GST-FH.4	Inhibitor	90.0%	Unkown
HY-N9220	6-Epi-albassitriol	Inhibitor	/	Unkown
HY-RS17117	fh Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23562	Fh Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23978	Cfh Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990955	Ebribafusp alfa	Inhibitor	96.40%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FH	MGD	MGI:95530
Macaca mulatta	FH	VGNC	VGNC:72659
Bos taurus	FH	VGNC	VGNC:28995
Rattus norvegicus	FH	RGD	RGD:2614
Canis familiaris	FH	VGNC	VGNC:40867
Felis catus	FH	VGNC	VGNC:62263
Others	FH	NCBI