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Pathways Recommended:	Anti-infection

Results for "

parasite infection

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Parasite (51) Aminoacyl-tRNA Synthetase (1) Antibiotic (8) Apoptosis (2) Autophagy (2) Bacterial (5) Chloride Channel (1) Cytochrome P450 (1) Dengue Virus (1) Dihydrofolate reductase (DHFR) (1) Endogenous Metabolite (3) Environmental Pollutants (1) Flavivirus (1) Fungal (1) GLUT (1) HBV (1) Interleukin Related (1) Mitochondrial Metabolism (1) nAChR (6) Phosphodiesterase (PDE) (1) PI4K (2) Proteasome (1) RAD51 (2) Reference Standards (7) STAT (1) Succinate Dehydrogenase (1) Transmembrane Glycoprotein (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (2) Infection (57) Inflammation/Immunology (6) Metabolic Disease (1)

By Targets:

Parasite (51)

Aminoacyl-tRNA Synthetase (1)

Antibiotic (8)

Apoptosis (2)

Autophagy (2)

Bacterial (5)

Chloride Channel (1)

Cytochrome P450 (1)

Dengue Virus (1)

Dihydrofolate reductase (DHFR) (1)

Endogenous Metabolite (3)

Environmental Pollutants (1)

Flavivirus (1)

Fungal (1)

GLUT (1)

HBV (1)

Interleukin Related (1)

Mitochondrial Metabolism (1)

nAChR (6)

Phosphodiesterase (PDE) (1)

PI4K (2)

Proteasome (1)

RAD51 (2)

Reference Standards (7)

STAT (1)

Succinate Dehydrogenase (1)

Transmembrane Glycoprotein (1)

By Research Areas:

Cancer (5)

Cardiovascular Disease (2)

Infection (57)

Inflammation/Immunology (6)

Metabolic Disease (1)

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Natural
Products

Targets Recommended: Parasite

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12640

Pyrantel pamoate 4 Publications Verification Pyrantel embonate	Parasite nAChR Antibiotic	Infection
Pyrantel pamoate (Pyrantel embonate) is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel pamoate can cause spasmodic muscle paralysis in parasites. Pyrantel pamoate can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis .

HY-W071746

Linolelaidic acid 1 Publications Verification Linoelaidic acid	Endogenous Metabolite Parasite Apoptosis	Infection Inflammation/Immunology
Linolelaidic acid (Linoelaidic acid) is an omega-6 trans fatty acid (TFA) that is an essential nutrient with oral activity. Linolelaidic acid can be added to enteral nutrition (oral), parenteral nutrition (intravenous), and infant formula. Linolelaidic acid has anti-inflammatory and anti-parasitic ((Parasite)) activities, and can induce Apoptosis. Linolelaidic acid is useful for research in infections .

HY-P990212

Anti-Mouse IL-6 Antibody (MP5-20F3) 1 Publications Verification	Interleukin Related STAT	Infection Inflammation/Immunology
Anti-Mouse IL-6 Antibody (MP5-20F3) is an anti-mouse IL-6 IgG1 monoclonal antibody. Anti-Mouse IL-6 Antibody (MP5-20F3) reshapes the tumor microenvironment by blocking IL-6. Anti-Mouse IL-6 Antibody (MP5-20F3) can inhibit the STAT3 pathway and enhance T cell infiltration. Anti-Mouse IL-6 Antibody (MP5-20F3) can be used for researches on inflammation and infection conditions such as malignant pleural effusion (MPE) .

HY-B1916

Acetylspiramycin 2 Publications Verification Spiramycin B; Spiramycin II; Foromacidin B	Antibiotic Bacterial Parasite	Infection
Acetylspiramycin (Spiramycin B) is an effective oral macrolide antibiotic produced by Streptomyces, It can inhibit the splenic lymphocyte transformation induced by phytohemagglutinin (PHA), LPS (HY-D1056) and antigen, reduce the procoagulant activity of macrophages, have good antibacterial effect on gram-positive bacteria, and is also an effective antigenic insect agent, which can be used to fight parasitic infection .

HY-125159

Derquantel PF-00520904	Parasite nAChR	Infection
Derquantel, a spirocyclic anthelmintic, is a competitive, orally active nicotinic acetylcholine receptor (nAChR) antagonist. Derquantel inhibits ACh-induced depolarization with an IC50 of 0.22 μM. By selectively antagonizing nAChRs on the somatic muscles of nematodes, Derquantel causes flaccid paralysis of muscles, thereby dislodging parasites from the host's gastrointestinal tract. Derquantel is applicable to research related to Haemonchus contortus infection and Ascaris suum infection .

HY-13836

ELQ-300	Parasite	Infection
ELQ-300 is a potent and orally bioavailable antimalarial agent, acts as an inhibitor of the reductive (Q_i) site of the cytochrome bc₁ complex (cyt bc₁). ELQ-300 inhibits growth of P. falciparum Dd2, Tm90-C2B, and D1 with IC₅₀ values of 6.6, 4.6 and 160 nM, respectively. ELQ-300 can be used for the research of antimalarial .

HY-N3980

Guaiol 1 Publications Verification Champacol; Guaiac alcohol	Autophagy RAD51	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Guaiol is a sesquiterpenoid alcohol with oral activity found in various traditional Chinese medicines, exhibiting biological activities such as anti-proliferative, autophagy-promoting, insecticidal, anti-anxiety, anti-inflammatory, diuretic, and blood pressure-lowering effects. Guaiol induces apoptosis in non-small cell lung cancer cells by regulating the stability of RAD51 through autophagy modulation. Guaiol can also act directly on parasites, inhibiting their growth by affecting the kinetoplast, mitochondrial matrix and plasma membrane of the promastigotes. Guaiol kills amastigotes at an IC₅₀ of 0.01 µg/mL. Guaiol can be used in research related to cancer, infections, cardiovascular diseases, and inflammatory conditions ^[4]

HY-17592A

Bithionol (sulfoxide) 2 Publications Verification	Parasite	Infection
Bithionol sulfoxide is an anti-infection agent for *parasites. Bithionol sulfoxide has mutagenic activity. Bithionol sulfoxide can be used in the research of parasite* infection, such as paragonimiasis, flukes andcestodes infection .

HY-A0130

Sulfalene Sulfametopyrazine; AS-18908	Parasite	Infection
Sulfalene (Sulfametopyrazine; AS-18908) is an orally active antimalarial agent. Sulfalene competes for para-aminobenzoic acid binding in plasmodial folic acid synthesis. Sulfalene, combined with Trimethoprim (HY-B0510), clears parasites, resolves fever, and resists induced resistance against drug-sensitive and drug-resistant Plasmodium falciparum. Sulfalene can be used for the research of acute falciparum malaria and Schistosoma mansoni infection .

HY-15537

Tilbroquinol 1 Publications Verification	Parasite Bacterial	Infection
Tilbroquinol is an orally active halogenated hydroxyquinoline antiprotozoal agent, mainly used for anti-amoebic infections . Tilbroquinol targets intestinal protozoa and Entamoeba histolytica to eliminate parasites in the intestinal lumen. Tilbroquinol can be used in research related to intestinal infections, intestinal amoebiasis and hepatic amoebiasis .

HY-169790

Phomarin	Dihydrofolate reductase (DHFR) Parasite Fungal	Infection
Phomarin is an inhibitor for dihydrofolate reductase (DHFR). Phomarin exhibits activity against Plasmodium *parasites* and fungi including Mycrobotryum violaceum and Botrytis cinerea. Phomarin can be used for the research of malaria and fungal infections .

HY-148315

GLUT1-IN-2	GLUT	Infection
GLUT1-IN-2 (compound 17) is a GLUT1 inhibitor with an IC₅₀ value of 12 μM. GLUT1-IN-2 shows inhibitory effect to Plasmodium falciparum hexose transporter PfHT with an IC₅₀ value of 13 μM. GLUT1-IN-2 can be used for the research of infection .

HY-124801

ABMA 1 Publications Verification	Flavivirus Dengue Virus Bacterial Parasite	Infection
ABMA is a broad-spectrum inhibitor of intracellular toxins and pathogens. ABMA efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and *parasite. ABMA selectively acts at host cell late endosomes rather than targeting toxin or pathogen itself. ABMA has broad-spectrum anti-infection* activity .

HY-176707

GSK2181306A	Parasite	Infection
GSK2181306A is a pan-FIKK inhibitor with an EC₅₀ value of 0.16 μM for parasite growth inhibition. GSK2181306A can be used to study Plasmodium infection .

HY-139587

Umifoxolaner ML-878	Parasite Chloride Channel	Infection
Umifoxolaner (ML-878), a γ-aminobutyric acid (GABA) regulated chloride channels antagonist, is a potent insecticide, and acaricide. Umifoxolaner can be uesd for parasite infection research .

HY-136637

NPD-001	Phosphodiesterase (PDE) Parasite	Infection
NPD-001 is a potent Trypanosoma brucei phosphodiesterases 1/2 (TbrPDEB1/2) inhibitor, with IC₅₀ values of 4 and 3 nM, respectively. NPD-001 also inhibits hPDE4. NPD-001 can increase cAMP levels in parasites, prevent cytokinesis, and cause the parasites to form multinucleated, multi-flagellated cells that eventually lyse. NPD-001 can be used for the research of infection .

HY-156685

EDI048	PI4K Parasite	Infection Metabolic Disease Cancer
EDI048 is an orally active, gut-restricted parasiticidal agent. EDI048 specifically binds to the ATP-binding site of Cryptosporidium phosphatidylinositol 4-kinase (CpPI (4) K), blocks parasite membrane biogenesis, arrests the pathogen at the schizont stage, and thus irreversibly clears the infection. EDI048 is rapidly converted to an inactive carboxylic acid metabolite via hepatic first-pass metabolism, with extremely low systemic exposure, good safety profile, and no cardiotoxicity, genotoxicity or off-target effects. EDI048 is used in studies of intestinal cryptosporidiosis in children .

HY-113715

Niclofolan BAY 9015; Menichlopholan; Menichlofolan; Bilevon	Environmental Pollutants Parasite	Infection
Niclofolan (BAY 9015) is an orally active anthelmintic agent. Niclofolan can be used in the research of parasite infection .

HY-12640R

Pyrantel pamoate (Standard) Pyrantel embonate (Standard)	Reference Standards Parasite nAChR Antibiotic	Infection
Pyrantel (pamoate) (Standard) is the analytical standard of Pyrantel (pamoate). This product is intended for research and analytical applications. Pyrantel pamoate (Pyrantel embonate) is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel pamoate can cause spasmodic muscle paralysis in parasites. Pyrantel pamoate can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis .

HY-138075

Obafluorin	Antibiotic Bacterial Parasite	Infection
Obafluorin is a β-lactone antibiotic. Obafluorin inhibits threonyl-tRNA synthetase (PfThrRS) with an IC₅₀ of 4.3 nM. Obafluorin inhibits the aminoacylation activity of EcThrRS and ObaO. Obafluorin exhibits Fe ³⁺-enhanced antibacterial activity. Obafluorin can be used in studies related to infections caused by bacterial and *parasites* such as Plasmodium .

HY-17656

C3361	Parasite	Infection
C3361 is a moderate specific Plasmodium falciparum hexose transporter 1 (PfHT1) and Plasmodium berghei hexose transporter 1 (PbHT1) inhibitor with K_i values of 8.6 and 9.4 μM. C3361 inhibits TgGT1 with a K_i of 82 μM. C3361 attenuates hepatic (IC₅₀ = 15 μM) and ookinete development of P. berghei. C3361 can suppress the growth of blood-stage *parasites. C3361 can be used for the research of infection*, such as malaria .

HY-108387

Morantel citrate	Parasite	Infection
Morantel citrate is a veterinary anthelmintic agent that inhibits parasitic infections in cattle, sheep and goats. Morantel citrate paralyzes the nervous system of the parasite, helping the animal expel the dead parasite from the body .

HY-12641

Pyrantel tartrate 1 Publications Verification	Parasite nAChR Antibiotic	Infection
Pyrantel tartrate is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel tartrate can cause spasmodic muscle paralysis in parasites. Pyrantel tartrate can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis .

HY-W049875

Nitroxynil	Parasite	Infection
Nitroxynil, anthelmintic agent, is active against parasites in both adult and immature stages. Nitroxynil is widely used for the research of infection of Fasciola hepatica .

HY-123601

DHQZ 36	Parasite	Infection
DHQZ 36 is a potent inhibitor of retrograde trafficking. DHQZ 36 inhibits *Leishmania amazonensis* infection in macrophages with an EC₅₀ of 13.63 μM. DHQZ 36 has potent anti-parasite activity .

HY-151485

Anti-infective agent 5	Parasite	Infection
Anti-infective agent 5 (compound 74) is an orally active inhibitor of *Trypanosoma cruzi* with an IC₅₀ value of 0.10 μM. Anti-infective agent 5 effectively reduces parasite burden in vivo. Anti-infective agent 5 can be used for the research of infection .

HY-W071746R

Linolelaidic acid (Standard) Linoelaidic acid (Standard)	Reference Standards Endogenous Metabolite Parasite Apoptosis	Infection Inflammation/Immunology
Linolelaidic acid (Standard) is the analytical standard of Linolelaidic acid. This product is intended for research and analytical applications. Linolelaidic acid (Linoelaidic acid) is an omega-6 trans fatty acid (TFA) that is an essential nutrient with oral activity. Linolelaidic acid can be added to enteral nutrition (oral), parenteral nutrition (intravenous), and infant formula. Linolelaidic acid has anti-inflammatory and anti-parasitic ((Parasite)) activities, and can induce Apoptosis. Linolelaidic acid is useful for research in infections[1][2][3].

HY-W973644

LY-266500	Mitochondrial Metabolism Parasite	Infection
LY-266500 is a succinyl CoA synthetase (SCS) specific inhibitor. LY-266500 has inhibitory effects on various parasites, such as Trypanosoma brucei brucei (IC₅₀ =0.6 μM) and Leishmania donovani (IC₅₀ =2.86 μM). LY-266500 can be used for research on parasitic infections .

HY-P3425

AGPV	Parasite	Infection
AGPV, a tetrapeptide, has the potential for prevention of schistosome parasite infection research .

HY-175345

CYP3A4-IN-5	Parasite	Infection
CYP3A4-IN-5 (Compound 5p) is a potent Leishmania major pteridine reductase 1 (Lm PTR1) inhibitor (IC₅₀=12.77 µM). CYP3A4-IN-5 is promising for research of parasite infection .

HY-12641A

Pyrantel	nAChR Parasite Antibiotic	Infection
Pyrantel is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel can cause spasmodic muscle paralysis in parasites. Pyrantel can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis .

HY-174342

ELQ-453	Cytochrome P450 Parasite	Infection
ELQ-453 is an inhibitor targeting the Q_o site of the Plasmodium falciparum cytochrome bc1 complex (CytB) with an IC₅₀ value of 0.57 nM. ELQ-453 blocks the mitochondrial function of the parasite, and suppresses Plasmodium infection in mosquitoes. ELQ-453 is promising for research of malaria .

HY-171956

Carmaphycin-17	Proteasome Parasite	Infection
Carmaphycin-17 (CP-17) is a selective 20S proteasome inhibitor with an EC₅₀ of 217 ?nM. Carmaphycin-17 has potent antimicrobial activity against Trichomonas vaginalis. Carmaphycin-17 overcomes Metronidazole (HY-B0318) resistance and significantly reduces parasite burden upon topical treatment without any apparent adverse effects in vaginal trichomonad infection mice model. Carmaphycin-17 can be used for sexually transmitted disease like trichomoniasis research .

HY-P3425A

AGPV TFA	Parasite	Infection
AGPV TFA, a tetrapeptide, has the potential for prevention of schistosome parasite infection research .

HY-N10624

Koshidacin B	Parasite	Infection
Koshidacin B is an antiplasmodial cyclic tetrapeptide with antiplasmodial activity against *P. falciparum* FCR3 and K1 strain with IC₅₀ values of 0.89 and 0.83 μM, respectively. Koshidacin B suppresses malaria parasites in vivo, it can be used for the research of parasites infection .

HY-179118

Antimalarial agent 53	Parasite	Infection
Antimalarial agent 53 (compound 31) is an antimalarial agent. Antimalarial agent 53 blocks protein synthesis by inhibiting the cytoplasmic ribosomes of malaria parasites, exhibiting potent antimalarial activity (IC₅₀ = 3.9 nM) and good selectivity. Antimalarial agent 53 has no cross resistance and good safety. Antimalarial agent 53 can be used for research on malaria .

HY-156028

FIKK9.1-IN-1	Parasite	Infection
FIKK9.1-IN-1 (Compound 1) is a FIKK9.1 inhibitor. FIKK9.1-IN-1 interacts with the ATP?binding residues in FIKK9.1. FIKK9.1-IN-1 is an antimalarial agent (IC₅₀: 2.68 μg/mL) and disrupts the parasite life cycle and leads to the death of parasites .

HY-12641R

Pyrantel tartrate (Standard)	Reference Standards Parasite nAChR Antibiotic	Infection
Pyrantel (tartrate) (Standard) is the analytical standard of Pyrantel (tartrate). This product is intended for research and analytical applications. Pyrantel tartrate is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel tartrate can cause spasmodic muscle paralysis in parasites. Pyrantel tartrate can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis .

HY-W049875R

Nitroxynil (Standard)	Reference Standards Parasite	Infection
Nitroxynil (Standard) is the analytical standard of Nitroxynil. This product is intended for research and analytical applications. Nitroxynil, anthelmintic agent, is active against parasites in both adult and immature stages. Nitroxynil is widely used for the research of infection of Fasciola hepatica .

HY-170777

SLU-10906	Parasite	Infection
SLU-10906 (Compound 63) is an orally active and potent Cryptosporidium inhibitor. SLU-10906 is active against the parasite in a cell-based infection model (EC₅₀= 0.19 μM) and non-cytotoxic. SLU-10906 is promising for research of cryptosporidiosis .

HY-151484

Anti-infective agent 4	Parasite	Infection
Anti-infective agent 4 (compound 73) is an orally active inhibitor of *Trypanosoma cruzi* with an IC₅₀ value of 0.016 μM. Anti-infective agent 4 effectively reduces parasite burden in vivo. Anti-infective agent 4 can be used for the research of infection .

HY-149093

Antileishmanial agent-14	Parasite	Infection
Antileishmanial agent-14 is a sulfuretin analog with potential activity against the parasite Leishmania donovani promastigotes (IC₅₀=4.1 μM). Antileishmanial agent-14 also inhibits infection by L. donovani amastigotes (IC₅₀=11.1 μM) .

HY-113648

LP10	HBV	Infection
LP10 is a non-azole CYP51 inhibitor with activity against Trypanosoma cruzi infection. Treatment with LP10 blocks the 14α-demethylation step, leading to disruption of the parasite cell membrane and ultimately triggering the death of important clinically relevant amoeba stages .

HY-N10197

Pulixin	Parasite Endogenous Metabolite	Infection
Pulixin prevents FREP1 from binding to P. falciparum-infected cell lysate. Pulixin blocks the transmission of the parasite to mosquitoes with an EC₅₀ of 11 µM. Pulixin also inhibits the proliferation of asexual-stage P. falciparum with an EC₅₀ of 47 nM .

HY-135625

BPH-1218	Parasite	Infection
BPH-1218 is an inhibitor of squalene synthase (SQS), with the IC₅₀ of 31 nM and 64 nM for TcSQS and HsSQS, respectively, that can be used as an anti-infective agent .

HY-B1916R

Acetylspiramycin (Standard) Spiramycin B (Standard); Spiramycin II (Standard); Foromacidin B (Standard)	Reference Standards Antibiotic Bacterial Parasite	Infection
Acetylspiramycin (Standard) is the analytical standard of Acetylspiramycin. This product is intended for research and analytical applications. Acetylspiramycin (Spiramycin B) is an effective oral macrolide antibiotic produced by Streptomyces, It can inhibit the splenic lymphocyte transformation induced by phytohemagglutinin (PHA), LPS (HY-D1056) and antigen, reduce the procoagulant activity of macrophages, have good antibacterial effect on gram-positive bacteria, and is also an effective antigenic insect agent, which can be used to fight parasitic infection[1][2][3][4].

HY-A0130R

Sulfalene (Standard) Sulfametopyrazine (Standard); AS-18908 (Standard)	Reference Standards Parasite	Infection
Sulfalene (Standard) is the analytical standard of Sulfalene. This product is intended for research and analytical applications. Sulfalene (Sulfametopyrazine; AS-18908) is an orally active antimalarial agent. Sulfalene competes for para-aminobenzoic acid binding in plasmodial folic acid synthesis. Sulfalene, combined with Trimethoprim (HY-B0510), clears parasites, resolves fever, and resists induced resistance against drug-sensitive and drug-resistant Plasmodium falciparum. Sulfalene can be used for the research of acute falciparum malaria and Schistosoma mansoni infection .

HY-124623

DNDI-8219	Parasite	Infection
DNDI-8219 (compound 58) is a potent selective and orally active trypanocidal agent, possessing inhibitory activity against Trypanosoma cruzi (T. cruzi) with an IC50 of 0.4 μM. DNDI-8219 has low cytotoxicity (L6 cells IC50 > 100 μM). DNDI-8219 can effectively cure chronic T. cruzi infection and markedly reduce parasite burdens in mouse model. DNDI-8219 has good solubility, metabolic stability and safety.

HY-128398

CpCDPK1/TgCDPK1-IN-2	Parasite	Infection
CpCDPK1/TgCDPK1-IN-2 (Compound 7r) is a CpCDPK1 and TgCDPK1 inhibitor with IC₅₀ values of 12 and 5 nM, respectively. CpCDPK1/TgCDPK1-IN-2 can be used in the research of apicomplexan protozoa-related diseases, such as the research of T. gondii, C. parvum and C. hominus infection .

HY-128399

CpCDPK1/TgCDPK1-IN-3	Parasite	Infection
CpCDPK1/TgCDPK1-IN-3 (Compound 20) is a CpCDPK1 and TgCDPK1 inhibitor with IC₅₀ values of 0.003 and 0.0036 µM, respectively. CpCDPK1/TgCDPK1-IN-3 can be used in the research of apicomplexan protozoa-related diseases, such as the research of T. gondii, C. parvum and C. hominus infection .

Cat. No.	Product Name

HY-L002

Anti-Infection Compound Library

4,238 compounds

An infection occurs when another organism enters a person’s body and causes disease. The organisms that cause infections are very diverse and can include things like viruses, bacteria, fungi, and parasites. The immune system is an effective barrier against infectious agents.

MCE provides a unique collection of 4,238 anti-infective compounds with anti-bacterial, anti-viral, anti-fungal and anti-parasite activities that can be used for drug screening and other research in anti-microbial area.

Cat. No.	Product Name	Target	Research Area