Niclofolan
Based on 1 Customer Validation
Niclofolan (BAY 9015) is an orally active anthelmintic agent. Niclofolan can be used in the research of parasite infection.
For research use only. We do not sell to patients.
- Purity: 99.46%
- CAS No.: 10331-57-4
- Formula: C12H6Cl2N2O6
- Molecular Weight:345.09
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Anti-Infection Compound Library
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All Parasite Isoforms
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Biological Activity
Niclofolan (0.12 mg/mL, 60 min) is effective against Gyrodactylus sp. under in vitro conditions[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Gyrodactylus sp. (parasite)
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Concentration:0.12 mg/mL
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Incubation Time:60 min
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Result:Reduced the number of live Gyrodactylus sp. By 100%.
Niclofolan (1 or 2 mg/kg, oral gavage ) shows therapeutic effects against P.iloktsuenesis infected rats[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:fasciola hepatica infected sheep[2]
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Dosage:2 mg/kg
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Administration:Intramuscular injection
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Result:Showed effectiveness against the infection and produced no untoward effects except for transient signs of pain at the site of injection.
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Animal Model:Rats infected with P.iloktsuenesis[4]
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Dosage:1 mg/kg, daily for 3 days; 2 mg/kg every other day for 2 times.
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Administration:Oral gavage
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Result:Reduced the worms in rats.
Chemical Information
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CAS No. 10331-57-4
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Appearance Solid
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Molecular Weight 345.09
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Formula C12H6Cl2N2O6
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Color Light yellow to yellow
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SMILES
O=[N+](C1=C(O)C(C2=C(O)C([N+]([O-])=O)=CC(Cl)=C2)=CC(Cl)=C1)[O-]
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Synonyms
BAY 9015; Menichlopholan; Menichlofolan; Bilevon
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (289.78 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (620 KB)
- English - EN (620 KB)
- Français - FR (620 KB)
- Deutsch - DE (620 KB)
- Norwegian - NO (620 KB)
- Español - ES (620 KB)
- Swedish - SV (620 KB)
- Italian - IT (620 KB)
- Portuguese - PT (620 KB)
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Handling Instructions (2659 KB)
References
[1]. T Eckhardt, Treatment of human fascioliasis with niclofolan. Gastroenterology. 1981 Oct; 81(4):795-8. [Content Brief]
[2]. B H Ali, T Hassan, et al. The effect of niclofolan on desert sheep experimentally infected with immature Fasciola gigantica. J Vet Pharmacol Ther. 1985 Dec;8(4):398-403. [Content Brief]
[4]. Rim H J, et al. Expermental chemotherapeutic effects of niclofolan (Bayer 9015, Bilevon) on the animals infected with Paragonimus westermani or P. iloktsuenensis. The Korean Journal of Parasitology, 1976, 14(2): 140-146. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8978 mL | 14.4890 mL | 28.9779 mL | 72.4449 mL |
| 5 mM | 0.5796 mL | 2.8978 mL | 5.7956 mL | 14.4890 mL | |
| 10 mM | 0.2898 mL | 1.4489 mL | 2.8978 mL | 7.2445 mL | |
| 15 mM | 0.1932 mL | 0.9659 mL | 1.9319 mL | 4.8297 mL | |
| 20 mM | 0.1449 mL | 0.7244 mL | 1.4489 mL | 3.6222 mL | |
| 25 mM | 0.1159 mL | 0.5796 mL | 1.1591 mL | 2.8978 mL | |
| 30 mM | 0.0966 mL | 0.4830 mL | 0.9659 mL | 2.4148 mL | |
| 40 mM | 0.0724 mL | 0.3622 mL | 0.7244 mL | 1.8111 mL | |
| 50 mM | 0.0580 mL | 0.2898 mL | 0.5796 mL | 1.4489 mL | |
| 60 mM | 0.0483 mL | 0.2415 mL | 0.4830 mL | 1.2074 mL | |
| 80 mM | 0.0362 mL | 0.1811 mL | 0.3622 mL | 0.9056 mL | |
| 100 mM | 0.0290 mL | 0.1449 mL | 0.2898 mL | 0.7244 mL |
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