2. Anti-infection
  3. Parasite
  4. Niclofolan

Niclofolan  (Synonyms: BAY 9015; Menichlopholan; Menichlofolan; Bilevon)

Cat. No.: HY-113715 Purity: 99.55%
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Niclofolan (BAY 9015) is an orally active anthelmintic agent. Niclofolan can be used in the research of parasite infection.

For research use only. We do not sell to patients.

Niclofolan Chemical Structure

Niclofolan Chemical Structure

CAS No. : 10331-57-4

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Solid + Solvent
10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Niclofolan Related Antibodies

Top Publications Citing Use of Products

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Niclofolan (BAY 9015) is an orally active anthelmintic agent. Niclofolan can be used in the research of parasite infection[1][2][3].

In Vitro

Niclofolan (0.12 mg/mL, 60 min) is effective against Gyrodactylus sp. under in vitro conditions[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Niclofolan Related Antibodies

Cell Viability Assay[3]

Cell Line: Gyrodactylus sp. (parasite)
Concentration: 0.12 mg/mL
Incubation Time: 60 min
Result: Reduced the number of live Gyrodactylus sp. By 100%.
In Vivo

Niclofolan (2 mg/kg, intramuscular injection) is effective against fasciola hepatica infected sheep[2].
Niclofolan (1 or 2 mg/kg, oral gavage ) shows therapeutic effects against P.iloktsuenesis infected rats[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: fasciola hepatica infected sheep[2]
Dosage: 2 mg/kg
Administration: Intramuscular injection
Result: Showed effectiveness against the infection and produced no untoward effects except for transient signs of pain at the site of injection.
Animal Model: Rats infected with P.iloktsuenesis[4]
Dosage: 1 mg/kg, daily for 3 days; 2 mg/kg every other day for 2 times.
Administration: Oral gavage
Result: Reduced the worms in rats.
Molecular Weight

345.09

Formula

C12H6Cl2N2O6
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=[N+](C1=C(O)C(C2=C(O)C([N+]([O-])=O)=CC(Cl)=C2)=CC(Cl)=C1)[O-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (289.78 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8978 mL 14.4890 mL 28.9779 mL
5 mM 0.5796 mL 2.8978 mL 5.7956 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8978 mL 14.4890 mL 28.9779 mL 72.4449 mL
5 mM 0.5796 mL 2.8978 mL 5.7956 mL 14.4890 mL
10 mM 0.2898 mL 1.4489 mL 2.8978 mL 7.2445 mL
15 mM 0.1932 mL 0.9659 mL 1.9319 mL 4.8297 mL
20 mM 0.1449 mL 0.7244 mL 1.4489 mL 3.6222 mL
25 mM 0.1159 mL 0.5796 mL 1.1591 mL 2.8978 mL
30 mM 0.0966 mL 0.4830 mL 0.9659 mL 2.4148 mL
40 mM 0.0724 mL 0.3622 mL 0.7244 mL 1.8111 mL
50 mM 0.0580 mL 0.2898 mL 0.5796 mL 1.4489 mL
60 mM 0.0483 mL 0.2415 mL 0.4830 mL 1.2074 mL
80 mM 0.0362 mL 0.1811 mL 0.3622 mL 0.9056 mL
100 mM 0.0290 mL 0.1449 mL 0.2898 mL 0.7244 mL
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Niclofolan Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Niclofolan10331-57-4BAY 9015 Menichlopholan Menichlofolan BilevonBAY9015BAY-9015ParasiteInfectionanthelminticGyrodactylusfasciola hepaticaP.iloktsuenesisInhibitorinhibitorinhibit

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