Expermental chemotherapeutic effects of niclofolan (Bayer 9015, Bilevon) on the animals infected with Paragonimus westermani or P. iloktsuenensis

  • Kisaengchunghak Chapchi. 1976 Dec;14(2):140-146. doi: 10.3347/kjp.1976.14.2.140.
Han Jong Rim  1 ,  Myung Se Kim ,  Joung Hwan Ha ,  Dong Shik Chang
Affiliations
  • 1. Department of Parasitology and Institute for Tropical Endemic Diseases, College of Medicine, Korea University, Seoul, Korea.
PMID: 12913443 DOI: 10.3347/kjp.1976.14.2.140
Abstract

The new drug niclofolan (bayer 9015, Bilevon), 5,5'-dichloro-2,2'-dihydroxy-3, 3'-dinitrobiphenyl, has been used in the treatment of Paragonimus westermani in dogs and cats and P. iloktsuenensis in rats. It was proved that administration of daily dose of 1.0 mg/kg body weight for 3 days or in 2 doses of 2.0 mg/kg body weight by alternate days were evidently effective for the infected dogs, cats and rats with the lung flukes, and toxic manifestations were not found.

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