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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
28 Results for "
resolvins
" in MedChemExpress (MCE) Product Catalog:
Products (28)
28 Results for "resolvins" in MCE Product Catalog:
5
Target:
Research Areas:
Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons .
2
Category:
Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology
Target:
1
Category:
Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology
Target:
1
1 Cited Publications
Synonyms: 17(R)-RvD1; AT-RvD1
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17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells . 17R-Resolvin D1 specificially inhibits TRPV3 with an IC50 of 398 nM and exhibits peripheral anti-nociceptive efficacy .
Synonyms: (-)-Resolvin E2
Research Areas:
Resolvin E2 ((-)-Resolvin E2) is an endogenous lipid mediator produced from eicosapentaenoic acid (EPA) under the catalysis of 5-lipoxygenase (5-LOX), and its production increases in hypoxic environments. Resolvin E2 antagonizes BLT1, partially activates ChemR23, and promotes ubiquitin-proteasome-mediated degradation of COX-2. Resolvin E2 reduces the production of prostaglandin E2, blocks polymorphonuclear leukocyte infiltration, and promotes the resolution of airway inflammation. Resolvin E2 ameliorates lipopolysaccharide (LPS) (HY-D1056)-induced depressive-like behaviors . Resolvin E2 can be used in research related to depression, murine peritonitis, neonatal asthma, and other conditions .
Cat. No.: HY-17639
CAS No.: 1251537-11-7
Synonyms: RX-10045
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Navamepent is an analog of naturally occurring resolvin E1 (a major dietary omega-3 polyunsaturated fatty-acid metabolite) with potent anti-inflammatory and cell survival benefits. Navamepent is highly effective against dry eye and goblet cell loss thereby accelerating tear production. Also, Navamepent can reduce corneal inflammation, epithelial damage, and accelerate corneal tissue repair. In addition, Navamepent can inhibit the release of several key proinflammatory mediators from corneal epithelial cells. Navamepent is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-114041S
Synonyms: RvE1-d4
Cat. No.: HY-113533
CAS No.: 1025684-60-9
Synonyms: RvD4
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Resolvin D4 (RvD4), a specialized proresolving mediator, can be produced in bioactive levels during S. aureus infection .
Synonyms: RvD2-d5
Cat. No.: HY-136540
CAS No.: 916888-47-6
Synonyms: RvD3
Research Areas:
Resolvin D3 (RvD3) is a docosahexaenoic acid (DHA) derived mediator. Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation .
Synonyms: RvD1-d5
Cat. No.: HY-145491
CAS No.: 578008-43-2
Cat. No.: HY-114041S1
CAS No.: 2714040-94-3
Synonyms: RvE1-d4-1
Cat. No.: HY-131993
CAS No.: 1781227-87-9
Synonyms: RvE4
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Research Areas:
Resolvin E4 (RvE4) is an endogenous metabolite that stimulates efferocytosis of apoptotic neutrophils and senescent erythrocytes. Resolvin E4 enhances resolution of hemorrhagic exudates and inflammation in vivo .
Cat. No.: HY-128031
CAS No.: 937738-63-1
Synonyms: RvD1 methyl ester
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Resolvin D1 methyl ester (RvD1 methyl ester) is the methyl ester of Resolvin D1 (HY-125527). Resolvin D1 methyl ester reduces triglyceride levels .
Cat. No.: HY-136540S
Synonyms: RvD3-d5
Cat. No.: HY-172632
Research Areas:
Resolvin D3 methyl ester is a methyl ester version of Resolvin D3 that may act as a lipophilic prodrug form which can alter its distribution and pharmacokinetic properties. Resolvin D3 is a potent immunoresolvent. Resolvin D3 can reduce neutrophil infiltration in vivo. Resolvin D3 can be produced in murine inflammatory exudates and human macrophages. Resolvin D3 can activate the human RvD1 and RvD5. Resolvin D3 is a potent enhancer of the uptake of apoptotic neutrophils by macrophages as well as a stimulator of IL-10 .
Cat. No.: HY-113533A
CAS No.: 528583-89-3
Synonyms: 17(R)-RvD4
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Research Areas:
17(R)-Resolvin D4 (17(R)-RvD4) is the R-enantiomer of Resolvin D4. Resolvin D4 (RvD4), a specialized proresolving mediator, can be produced in bioactive levels during S. aureus infection .
Cat. No.: HY-W708469
CAS No.: 810668-53-2
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Resolvin D2 methyl ester is an ester derivative of the DHA (HY-B2167) metabolite Resolvin D2 (HY-121636) with anti-inflammatory and anti-infective activities. Resolvin D2 is a leukocyte modulator and a potent inhibitor of neuronal TRPV1 (IC50=0.1 nM) and TRPA1 (IC50=2 nM). Resolvin D2 can be used in sepsis research .
Cat. No.: HY-139232
CAS No.: 1427475-53-3
Synonyms: 17(R)-RvD3
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Research Areas:
17(R)-Resolvin D3 is a metabolite of docosahexaenoic acid (DHA). 17(R)-Resolvin D3 has anti-inflammatory activity .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
