865532-70-3
Chemical Structure
Resolvin E2
Synonym(s): (-)-Resolvin E2
- CAS No.: 865532-70-3
- Formula:C20H30O4
- Molecular Weight:334.45
IUPAC Name: (5S,6E,8Z,11Z,14Z,16E,18R)-5,18-dihydroxyicosa-6,8,11,14,16-pentaenoic acid
InChIKey: KPRHYAOSTOHNQA-NNQKPOSRSA-N
SMILES: CC[C@@H](O)/C=C/C=C\C/C=C\C/C=C\C=C\[C@@H](O)CCCC(O)=O
Biological Activity:
Resolvin E2 ((-)-Resolvin E2) is an endogenous lipid mediator produced from eicosapentaenoic acid (EPA) under the catalysis of 5-lipoxygenase (5-LOX), and its production increases in hypoxic environments. Resolvin E2 antagonizes BLT1, partially activates ChemR23, and promotes ubiquitin-proteasome-mediated degradation of COX-2. Resolvin E2 reduces the production of prostaglandin E2, blocks polymorphonuclear leukocyte infiltration, and promotes the resolution of airway inflammation. Resolvin E2 ameliorates lipopolysaccharide (LPS) (HY-D1056)-induced depressive-like behaviors. Resolvin E2 can be used in research related to depression, murine peritonitis, neonatal asthma, and other conditions[1][2][3][4].
The product specifications provided below refer solely to the active content of Resolvin E2.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Resolvin E2 | 98.5% | Resolvin E2 ((-)-Resolvin E2) is an endogenous lipid mediator produced from eicosapentaenoic acid (EPA) under the catalysis of 5-lipoxygenase (5-LOX), and its production increases in hypoxic environments. Resolvin E2 antagonizes BLT1, partially activates ChemR23, and promotes ubiquitin-proteasome-mediated degradation of COX-2. Resolvin E2 reduces the production of prostaglandin E2, blocks polymorphonuclear leukocyte infiltration, and promotes the resolution of airway inflammation. Resolvin E2 ameliorates lipopolysaccharide (LPS) (HY-D1056)-induced depressive-like behaviors. Resolvin E2 can be used in research related to depression, murine peritonitis, neonatal asthma, and other conditions. The product specifications provided below refer solely to the active content of Resolvin E2. |
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Similarity Score 0.91
HY-131993Resolvin E4 -
Similarity Score 0.89
HY-113484Leukotriene B5 -
Similarity Score 0.87
HY-1134925(S)15(S)-DiHETE -
Similarity Score 0.85
HY-1135135-HEPE -
Similarity Score 0.85
HY-N7801(±)5-HEPE -
Similarity Score 0.83
HY-10149518-HEPE -
Similarity Score 0.83
HY-1134345(S)-HETE -
Similarity Score 0.83
HY-113434A5(R)-HETE -
Similarity Score 0.83
HY-113434B5-HETE -
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References
- [1]. Deyama S, et al. Resolvin E1/E2 ameliorate lipopolysaccharide-induced depression-like behaviors via ChemR23. Psychopharmacology (Berl). 2018;235(1):329-336. [Content Brief]
- [2]. Tjonahen E, et al. Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis. Chem Biol. 2006;13(11):1193-1202. [Content Brief]
- [3]. Hamaguchi A, et al. Resolvin E1 and Resolvin E2 suppress cyclooxygenase-2 expression through ubiquitin-proteasome-mediated degradation in human macrophage-like U937 cells. Prostaglandins Other Lipid Mediat. 2026;183:107064. [Content Brief]
- [4]. Ramar M, et al. Intra-Airway Treatment with Synthetic Lipoxin A4 and Resolvin E2 Mitigates Neonatal Asthma Triggered by Maternal Exposure to Environmental Particles. Int J Mol Sci. 2023;24(7):6145. Published 2023 Mar 24. [Content Brief]
