2. MAPK/ERK Pathway
  3. p38 MAPK JNK
  4. SX 011

SX 011 is a p38 inhibitor with IC50s of 9 nM and 90 nM against p38α and p38β, respectively. SX 011 also inhibits JNK-2 with an IC50 of 100 nM. SX-011 is orally bioavailable.

For research use only. We do not sell to patients.

SX 011 Chemical Structure

SX 011 Chemical Structure

CAS No. : 309913-42-6

Size Price Stock Quantity
5 mg USD 364 In-stock
10 mg USD 546 In-stock
25 mg USD 1090 In-stock
50 mg USD 1640 In-stock
100 mg USD 2460 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

SX 011 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SX 011 is a p38 inhibitor with IC50s of 9 nM and 90 nM against p38α and p38β, respectively. SX 011 also inhibits JNK-2 with an IC50 of 100 nM. SX-011 is orally bioavailable[1].

IC50 & Target[1]

p38α

9 nM (IC50)

p38β

90 nM (IC50)

p38δ

> 300,000 nM (IC50)

p38γ

> 300,000 nM (IC50)

JNK2

100 nM (IC50)

JNK1

> 300,000 nM (IC50)

In Vitro

SX-011 inhibits LPS stimulated TNFα and interleukin-1β (IL-1β) from human peripheral blood mononuclear cells (PBMC) with an IC50 of 200 nM and 900 nM, respectively. Additionally, IL-6 (IC50 250 nM) and IL-8 (IC50 100 nM) are significantly inhibited in this assay[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SX 011 Related Antibodies
In Vivo

SX-011 is orally bioavailable in preclinical species (rat, 24%; monkey, 29%; dog, 43%) and has demonstrated efficacy in both acute and chronic models of inflammation in rats. Rat t1/2 = 30 min[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

483.96

Formula

C26H27ClFN3O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N(C)C)C(C1=CN(C)C2=C1C=C(C(N3CCC(CC4=CC=C(F)C=C4)CC3)=O)C(Cl)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (206.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0663 mL 10.3314 mL 20.6629 mL
5 mM 0.4133 mL 2.0663 mL 4.1326 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (5.17 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (5.17 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0663 mL 10.3314 mL 20.6629 mL 51.6572 mL
5 mM 0.4133 mL 2.0663 mL 4.1326 mL 10.3314 mL
10 mM 0.2066 mL 1.0331 mL 2.0663 mL 5.1657 mL
15 mM 0.1378 mL 0.6888 mL 1.3775 mL 3.4438 mL
20 mM 0.1033 mL 0.5166 mL 1.0331 mL 2.5829 mL
25 mM 0.0827 mL 0.4133 mL 0.8265 mL 2.0663 mL
30 mM 0.0689 mL 0.3444 mL 0.6888 mL 1.7219 mL
40 mM 0.0517 mL 0.2583 mL 0.5166 mL 1.2914 mL
50 mM 0.0413 mL 0.2066 mL 0.4133 mL 1.0331 mL
60 mM 0.0344 mL 0.1722 mL 0.3444 mL 0.8610 mL
80 mM 0.0258 mL 0.1291 mL 0.2583 mL 0.6457 mL
100 mM 0.0207 mL 0.1033 mL 0.2066 mL 0.5166 mL
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SX 011 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SX 011309913-42-6SX011SX-011p38 MAPKJNKc-Jun N-terminal kinaseInhibitorinhibitorinhibit

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