Tallimustine hydrochloride (Synonyms: FCE 24517 hydrochloride)

Cat. No.: HY-105270A Pureza: 98.23%: Ficha de datos
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Tallimustine hydrochloride, a distamycin-A derivative, is an anticancer agent.

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Tallimustine hydrochloride Estructura química

No. CAS : 118438-45-2

Tamaño	Stock	Cantidad
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
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100 mg	Obtener un presupuesto

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Other Forms of Tallimustine hydrochloride:

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Descripciòn

Tallimustine hydrochloride, a distamycin-A derivative, is an anticancer agent^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
L1210	IC₅₀	0.05 μg/mL Compound: 1 (Tallimustine)	In vitro inhibition of L1210 murine leukemia (Drug sensitivity was determined by counting surviving cells after 48 hr of continuous exposure to at least 4 conc. of drug) In vitro inhibition of L1210 murine leukemia (Drug sensitivity was determined by counting surviving cells after 48 hr of continuous exposure to at least 4 conc. of drug)	10.1016/0960-894X(96)00205-3
L1210	IC₅₀	0.42 nM Compound: tallimustine	Inhibition of growth in L1210 leukemia cells resistant to doxorubicin(DX). Inhibition of growth in L1210 leukemia cells resistant to doxorubicin(DX).	[PMID: 10893305]
L1210	IC₅₀	1.2 nM Compound: tallimustine	Inhibition of growth in L1210 leukemia cells resistant to Tallimustine. Inhibition of growth in L1210 leukemia cells resistant to Tallimustine.	[PMID: 10893305]
L1210	IC₅₀	24.4 ng/mL Compound: 7a (FCE 24517, Tallimustine)	The activity in vitro on L1210 murine leukemia cells, activity expressed as IC50 The activity in vitro on L1210 murine leukemia cells, activity expressed as IC50	10.1016/S0960-894X(01)80515-1
L1210	IC₅₀	50.3 ng/mL Compound: 1a	In vitro test for cytotoxicity after 48 hr of continuous exposure against L1210 murine leukemia cells In vitro test for cytotoxicity after 48 hr of continuous exposure against L1210 murine leukemia cells	10.1016/S0960-894X(97)10120-2
L1210	IC₅₀	50.3 ng/mL Compound: 4 (Tallimustine)	In vitro inhibition of L1210 murine leukemia (Drug sensitivity was determined by counting surviving cells after 48 hr of continuous exposure to at least 4 conc. of drug) In vitro inhibition of L1210 murine leukemia (Drug sensitivity was determined by counting surviving cells after 48 hr of continuous exposure to at least 4 conc. of drug)	10.1016/0960-894X(96)00204-1
L1210	IC₅₀	68.5 nM Compound: 1 (Tallimustine)	In vitro cytotoxicity against L1210 murine leukemia cells In vitro cytotoxicity against L1210 murine leukemia cells	[PMID: 10937717]
L1210	IC₅₀	68.5 nM Compound: tallimustine	In vitro antitumor activity evaluated against L1210 murine leukemia cell line In vitro antitumor activity evaluated against L1210 murine leukemia cell line	[PMID: 10893305]

Peso molecular

734.08

Fòrmula

C₃₂H₃₉Cl₃N₁₀O₄

No. CAS

118438-45-2

Appearance

Solid

Color

Light yellow to light brown

SMILES

O=C(C1=CC=C(N(CCCl)CCCl)C=C1)NC2=CN(C)C(C(NC3=CN(C)C(C(NC4=CN(C)C(C(NCCC(N)=N)=O)=C4)=O)=C3)=O)=C2.Cl

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad

In Vitro:

DMSO : 83.33 mg/mL (113.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3622 mL	6.8112 mL	13.6225 mL
5 mM	0.2724 mL	1.3622 mL	2.7245 mL
10 mM	0.1362 mL	0.6811 mL	1.3622 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 98.23%

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Ficha de datos (267 KB) SDS (252 KB)

COA (247 KB) HNMR (322 KB) RP-HPLC (252 KB) MS (69 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Herzig MC, et al. Tallimustine lesions in cellular DNA are AT sequence-specific but not region-specific. Biochemistry. 1999 Oct 19;38(42):14045-55. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3622 mL	6.8112 mL	13.6225 mL	34.0562 mL
	5 mM	0.2724 mL	1.3622 mL	2.7245 mL	6.8112 mL
	10 mM	0.1362 mL	0.6811 mL	1.3622 mL	3.4056 mL
	15 mM	0.0908 mL	0.4541 mL	0.9082 mL	2.2704 mL
	20 mM	0.0681 mL	0.3406 mL	0.6811 mL	1.7028 mL
	25 mM	0.0545 mL	0.2724 mL	0.5449 mL	1.3622 mL
	30 mM	0.0454 mL	0.2270 mL	0.4541 mL	1.1352 mL
	40 mM	0.0341 mL	0.1703 mL	0.3406 mL	0.8514 mL
	50 mM	0.0272 mL	0.1362 mL	0.2724 mL	0.6811 mL
	60 mM	0.0227 mL	0.1135 mL	0.2270 mL	0.5676 mL
	80 mM	0.0170 mL	0.0851 mL	0.1703 mL	0.4257 mL
	100 mM	0.0136 mL	0.0681 mL	0.1362 mL	0.3406 mL

Tallimustine hydrochloride Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tallimustine118438-45-2FCE 24517FCE24517FCE-24517Drug DerivativeDrug derivativedistamycin-A derivative anticancer agentInhibitorinhibitorinhibit

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Tallimustine hydrochloride (Synonyms: FCE 24517 hydrochloride)

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Other Forms of Tallimustine hydrochloride:

Tallimustine hydrochloride Related Antibodies

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Actividad biológica

Pureza y Documentación

Referencias

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Calculadora de dilución

Complete Stock Solution Preparation Table

Tallimustine hydrochloride Related Classifications

Keywords:

Productos vistos recientemente:

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