1. Neuronal Signaling
    NF-κB
    PI3K/Akt/mTOR
  2. Amyloid-β
    NF-κB
    mTOR
    Keap1-Nrf2
  3. TML-6

TML-6 

Cat. No.: HY-137315 Purity: 98.34%
Handling Instructions

TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ). TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti-oxidative Nrf2 gene. TML-6 has the potential for Alzheimer’s disease (AD) research.

For research use only. We do not sell to patients.

TML-6 Chemical Structure

TML-6 Chemical Structure

CAS No. : 1462868-88-7

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5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 580 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ). TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti-oxidative Nrf2 gene. TML-6 has the potential for Alzheimer’s disease (AD) research[1].

IC50 & Target[1]

NF-κB

 

mTOR

 

In Vitro

TML-6 (0.65-5.24 µg/mL; for 24 h) reduces the protein expression levels of APP and phospho-NF-κB, and induces the protein expression level of ApoE. TML-6 inhibits the mTOR signaling pathway through the suppression of phospho-mTOR[1].
TML-6 (0.31, 0.63, 2.5, 5, 10, 20 μM; 24 h) reveals no cytotoxicity in Huh-7 cells at concentrations below 5 μM and has an IC50 of 4.19 µg/mL (8 μM)[1].
TML-6 (1.05, 2.09, 3.14, 4.19 μg/mL; 24 h) reduces the production of Aβ40 and Aβ42 between 1.05, 2.09 and 3.14 μg/mL (equal to 2, 4 and 6 μM) in a dose-dependent manner in N2a/APPswe cell[1].
TML-6 can exhibit transcriptional activation of the Nrf2 gene in a dose-dependent manner, with the highest activity at a concentration of 1.32 µg/mL[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Huh-7 cells
Concentration: 0.65, 1.31, 1.96, 2.61, 3.93, 5.24 µg/mL
Incubation Time: For 24 hours
Result: Reduced the amyloid precursor protein (APP) protein expression level by 60% and decreased the level of phosphorylated NF-κB by about 50% at a dose of 1.96 µg/mL after 24 h treatment.
Induced the protein expression level of ApoE by approximately 44% at a dose of 2.62 µg/mL.
In Vivo

TML-6 (diet; 150 mg/kg/day; for four months) treatment results in significant improvement in learning, suppression of the microglial activation marker Iba-1, and reduction in Aβ in the brain[1].
TML-6 (oral; 150 mg/kg) has a T1/2 of 1.27 hours, a Cmax of 35.9 ng/mL and an AUC of 177 ng•hr/mL[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-month-old 3xTg (mutations: APPKM670/671NL, MAPTP301L and PSEN1M146V) AD transgenic mice[1]
Dosage: 150 mg/kg
Administration: Diet; daily; for four months
Result: Improved the learning behaviors, significantly suppressed the Aβ levels and Iba-1 expression in the brain of 3xTg AD transgenic mice.
Animal Model: SD rats[1]
Dosage: 150 mg/kg (Pharmacokinetic Analysis)
Administration: Oral
Result: Had a T1/2 of 1.27 hours, a Cmax of 35.9 ng/mL and an AUC of 177 ng•hr/mL.
Molecular Weight

523.62

Formula

C₃₀H₃₇NO₇

CAS No.

1462868-88-7

SMILES

O=C(N(CC)CC)CC(C)(C(/C=C/C1=CC=C(OC)C(OC)=C1)=O)C(/C=C/C2=CC=C(OC)C(OC)=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 120 mg/mL (229.17 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9098 mL 9.5489 mL 19.0978 mL
5 mM 0.3820 mL 1.9098 mL 3.8196 mL
10 mM 0.1910 mL 0.9549 mL 1.9098 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 98.34%

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Keywords:

TML-6TML6TML 6Amyloid-βNF-κBmTORKeap1-Nrf2β-amyloid peptideAbetaNuclear factor-κBNuclear factor-kappaBMammalian target of RapamycinorallyAlzheimer’sdiseaseADApo Eanti-oxidativeNrf2Huh-7Aβ40Aβ42,Inhibitorinhibitorinhibit

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