FAM3B - FAM3 metabolism regulating signaling molecule B Gene

Also Known as 2-21; ORF9; PANDER; PRED44; C21orf11; C21orf76

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54097

About FAM3B

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:41,304,242-41,357,727 (from NCBI)

This gene has 6 transcripts (splice variants), 123 orthologues and 3 paralogues. Biased expression in duodenum (RPKM 47.4), small intestine (RPKM 44.3) and 11 other tissues.

Summary

Involved in Insulin secretion. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

FAM3B Products (2)

mRNA Protein Name
NM_058186.4 NP_478066.3 protein FAM3B isoform a precursor
NM_206964.2 NP_996847.1 protein FAM3B isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in insulin secretion IDA
IDA: Inferred from direct assay
12160727 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein FAM3B

  • D21M16SJHU19e

FAM3B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FAM3B P58499 FUT3 Homo sapiens P21217
Y2H Prey Pooling
32296183
Intra
FAM3B P58499 FUT3 Homo sapiens P21217
Y2H Array
32296183
Intra
FAM3B P58499 FUT3 Homo sapiens P21217
Anti Tag CoIP
33961781
Intra
FAM3B P58499 GLE1 Homo sapiens Q53GS7
Y2H Array
32814053
Intra
FAM3B P58499 GLE1 Homo sapiens Q53GS7
Validated Y2H
32814053
Intra
FAM3B P58499 GLE1 Homo sapiens Q53GS7
Y2H Pooling
32814053
Intra
FAM3B P58499 LMNA Homo sapiens P02545
Y2H Array
32814053
Intra
FAM3B P58499 LMNA Homo sapiens P02545
Validated Y2H
32814053
Intra
FAM3B P58499 LMNA Homo sapiens P02545
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FAM3B Proteins

Cat. No. Product Name Accession Purity
HY-P70386 FAM3B Protein, Human (HEK293, Fc) P58499-1 (E30-S235) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700631 FAM3B Protein, Human (His, Myc) P58499-1 (E30-S235) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Multiple Benign Circumferential Skin Creases On Limbs

  • Ccsf

  • Circumferential Skin Creases, Kunze Type

  • Congenital Circumferential Skin Folds

  • Kunze-Riehm Syndrome

  • Kunze Riehm Syndrome

  • Michelin Tire Baby Syndrome
Deafness, Autosomal Recessive 17

  • DFNB17

  • Autosomal Recessive Nonsyndromic Deafness 17

  • Autosomal Recessive Deafness 17
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04712 FAM3B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20016 Fam3b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26519 Fam3b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus FAM3B MGD MGI:1270150
Canis familiaris FAM3B VGNC VGNC:40678
Macaca mulatta FAM3B VGNC VGNC:72263
Bos taurus FAM3B VGNC VGNC:28810
Felis catus FAM3B VGNC VGNC:62111
Rattus norvegicus FAM3B RGD RGD:1311662
Others FAM3B NCBI