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FUT3 - fucosyltransferase 3 (Lewis blood group) Gene

Also Known as LE; Les; FT3B; CD174; FucT-III

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2525

About FUT3

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:5,842,888-5,857,122 (from NCBI)

This gene has 10 transcripts (splice variants), 384 orthologues, 7 paralogues and is associated with 1 phenotype. Biased expression in colon (RPKM 29.8), esophagus (RPKM 25.0) and 7 other tissues.

Summary

The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and Bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor Polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Differences in the expression of this gene are associated with host susceptibility to viral Infection. [provided by RefSeq, Aug 2020]

FUT3 Products (12)

mRNA	Protein	Name
NM_000149.4	NP_000140.1	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001097639.3	NP_001091108.3	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001097640.3	NP_001091109.3	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001097641.3	NP_001091110.3	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001374740.1	NP_001361669.1	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001382744.1	NP_001369673.1	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001382745.1	NP_001369674.1	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001382746.1	NP_001369675.1	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001382747.1	NP_001369676.1	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001382748.2	NP_001369677.1	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001382749.2	NP_001369678.1	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001382750.2	NP_001369679.1	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	IDA IDA: Inferred from direct assay	1740457	GOA
enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	IMP IMP: Inferred from mutant phenotype	10211701	GOA
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	IDA IDA: Inferred from direct assay	1740457	GOA
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	IMP IMP: Inferred from mutant phenotype	10211701	GOA
enables alpha-(1->3)-fucosyltransferase activity	IDA IDA: Inferred from direct assay	1977660	GOA
enables fucosyltransferase activity	IDA IDA: Inferred from direct assay	7721776	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ceramide metabolic process	IDA IDA: Inferred from direct assay	7721776	GOA
involved in fucosylation	IDA IDA: Inferred from direct assay	1977660	GOA
involved in macromolecule glycosylation	IDA IDA: Inferred from direct assay	1977660	GOA
involved in oligosaccharide biosynthetic process	IDA IDA: Inferred from direct assay	1977660	GOA
involved in oligosaccharide metabolic process	IDA IDA: Inferred from direct assay	1740457	GOA
involved in positive regulation of cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	11058871	GOA
involved in protein N-linked glycosylation	IDA IDA: Inferred from direct assay	29593094	GOA
involved in protein O-linked glycosylation	IDA IDA: Inferred from direct assay	29593094	GOA
involved in regulation of cell migration	IMP IMP: Inferred from mutant phenotype	27453266	GOA
involved in regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	27453266	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in membrane	IDA IDA: Inferred from direct assay	1977660	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FUT3 Protein Structure

Glyco_transf_10

0
100
200
300
361 a.a.

Protein Preferred Names	Protein Names
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase 3

FUT3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FUT3	P21217	TTMP	Homo sapiens	Q5BVD1	Validated Y2H	32296183
Intra	FUT3	P21217	SLC41A2	Homo sapiens	Q96JW4	Validated Y2H	32296183
Intra	FUT3	P21217	FAM3B	Homo sapiens	P58499	Validated Y2H	32296183
Intra	FUT3	P21217	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Blood Group, Lewis System	LE Lewis Blood Group System Les
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-E70154	Fucosyltransferase 3		/	Unkown
HY-RS05154	FUT3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown