Gli1 - GLI-Kruppel family member GLI1 Gene

Also Known as Zfp5; Zfp-5

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14632

About Gli1

Chromosome 10: 127,165,751-127,177,843 reverse strand.GRCm39:CM001003.3

This gene has 5 transcripts (splice variants), 201 orthologues, 13 paralogues and is associated with 1 phenotype. Biased expression in limb E14.5 (RPKM 44.9), subcutaneous fat pad adult (RPKM 27.9) and 14 other tissues.

Summary

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and microtubule binding activity. Involved in regulation of osteoblast differentiation. Acts upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway involved in cell-cell signaling; and regionalization. Located in axoneme and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; long bone; and sensory organ. Orthologous to human GLI1 (Gli family zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]

Gli1 Products (1)

mRNA Protein Name
NM_010296.2 NP_034426.2 zinc finger protein GLI1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
17442700 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15614767 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
16396903 MGI
enables microtubule binding IDA
IDA: Inferred from direct assay
11717126 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10531011 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cerebellar cortex morphogenesis IGI
IGI: Inferred from genetic interaction
16571625 MGI
acts upstream of or within dorsal/ventral pattern formation IGI
IGI: Inferred from genetic interaction
16342201 MGI
acts upstream of or within liver regeneration IMP
IMP: Inferred from mutant phenotype
23740243 MGI
acts upstream of or within lung development IGI
IGI: Inferred from genetic interaction
10725236 MGI
acts upstream of or within notochord regression IGI
IGI: Inferred from genetic interaction
10725236 MGI
acts upstream of or within pituitary gland development IGI
IGI: Inferred from genetic interaction
10725236 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15614767 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16254602 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
17035233 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16611981 MGI
acts upstream of or within proximal/distal pattern formation IGI
IGI: Inferred from genetic interaction
16342201 MGI
acts upstream of or within regulation of hepatocyte proliferation IMP
IMP: Inferred from mutant phenotype
23740243 MGI
involved in regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
22493482 MGI
acts upstream of or within response to wounding IDA
IDA: Inferred from direct assay
23740243 MGI
acts upstream of or within response to wounding IMP
IMP: Inferred from mutant phenotype
23740243 MGI
acts upstream of or within smoothened signaling pathway IDA
IDA: Inferred from direct assay
9769173 MGI
acts upstream of or within smoothened signaling pathway IGI
IGI: Inferred from genetic interaction
16571625 MGI
acts upstream of or within spermatogenesis IDA
IDA: Inferred from direct assay
11717126 MGI
acts upstream of or within ventral midline development IGI
IGI: Inferred from genetic interaction
10725236 MGI
Cellular Component GO Annotation Evidence References Source
located in axoneme IDA
IDA: Inferred from direct assay
16254602 MGI
located in cilium IDA
IDA: Inferred from direct assay
16254602 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
11717126 MGI
located in cytoplasm IGI
IGI: Inferred from genetic interaction
16316410 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11717126 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Gli1 Protein Structure

COG5236

COG5236: cl28715 (195 - 437)

FOXP-CC

FOXP-CC: cl24666 (239 - 267)

ZF_C2H2

ZF_C2H2: sd00017 (305 - 327)

ZF_C2H2

ZF_C2H2: sd00017 (335 - 358)

ZF_C2H2

ZF_C2H2: sd00017 (366 - 387)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1111 a.a.
Protein Preferred Names Protein Names

zinc finger protein GLI1

  • glioma-associated oncogene homolog

  • zinc finger protein 5

Gli1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80142 Gli1 Antibody (YA414) WB, IHC-P Mouse, Rat

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-13242 Taladegib Inhibitor 99.92% Phase 2

Pre-clinical Phase

Bioactive Molecules (31)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13901 GANT 61 99.80% Unkown
HY-P4860 Adropin (34-76) (human, mouse, rat) 98.23% Unkown
HY-W269593 Perfluorodecanoic acid Inhibitor 98.0% Unkown
HY-13282 GANT 58 Antagonist 99.37% Unkown
HY-N2112 Glaucocalyxin A 99.88% Unkown
HY-18366A RU-SKI 43 hydrochloride Inhibitor 98.81% Unkown
HY-122590 Glabrescione B Inhibitor 98.08% Unkown
HY-107551 Hh Pathway-IN-1 99.06% Unkown
HY-107408 SANT 2 Antagonist 99.41% Unkown
HY-W111144 T-1330 Inhibitor / Unkown
HY-18366 RU-SKI 43 Inhibitor / Unkown
HY-RS05472 GLI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-13242A Taladegib hydrochloride Inhibitor / Unkown
HY-137567 Prostaglandin E1 ethanolamide Activator / Unkown
HY-143400 HSP70-IN-3 Inhibitor / Unkown
HY-147670 TPB15 / Unkown
HY-159893 SMO-IN-5 / Unkown
HY-161459 GLI1-IN-1 / Unkown
HY-162273 Antibacterial agent 189 Inhibitor / Unkown
HY-176056 Hedgehog IN-9 / Unkown
HY-182641 SAG analog (cis-isomer) Activator / Unkown
HY-183335 SMO-IN-6 / Unkown
HY-N8270 Physalin H Inhibitor / Unkown
HY-N9684 Degalactotigonin / Unkown
HY-RS05473 Gli1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05474 Gli1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05480 GLIS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-122017 Methoxy-SANT-2 Antagonist / Unkown
HY-13901R GANT 61 (Standard) / Unkown
HY-172449 GLI1-IN-3 Inhibitor / Unkown
HY-W338819 Clobetasol / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gli1 NCBI NCBI:2735