Hsp90-IN-17
Hsp90-IN-17 is a Hsp90 inhibitor. Hsp90-IN-17 binds to the N-terminal ATP-binding pocket of Hsp90, inhibits its chaperone function, and induces the degradation of Hsp90 client proteins. Hsp90-IN-17 inhibits cancer cell proliferation. Hsp90-IN-17 can be used in the research of ovarian cancer.
For research use only. We do not sell to patients.
- CAS No.: 1253584-78-9
- Formula: C21H20N4O7
- Molecular Weight:440.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HSP90 |
Hsp90-IN-17 (compound 17) (18 h) potently inhibits binding to human Hsp90α in a fluorescence polarization assay with a DC50 of 0.017 μM[1].
Hsp90-IN-17 has a solubility of 155 μM in neutral (pH 7) aqueous buffer[1].
Hsp90-IN-17 (72 h) inhibits proliferation of human ovarian A2780 tumor cells with an IC50 of 0.362 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1253584-78-9
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Molecular Weight 440.41
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Formula C21H20N4O7
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SMILES
O=C(C1=NOC(C2=C(OC3=CC=C([N+]([O-])=O)C=C3)C=C(O)C=C2O)=C1)NC4CCNCC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hsp90-IN-17 Related Classifications
HY-148215 Related Classifications
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