1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. XPC-6444

XPC-6444 

Cat. No.: HY-128772
Handling Instructions

XPC-6444 is a highly potent, isoform-selective, and CNS-penetrant NaV1.6 inhibitor (IC50=41 nM for hNaV1.6). XPC-6444 also displays potent block of NaV1.2 (IC50=125 nM). XPC-6444 shows anticonvulsant activity.

For research use only. We do not sell to patients.

XPC-6444 Chemical Structure

XPC-6444 Chemical Structure

CAS No. : 2230144-21-3

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Description

XPC-6444 is a highly potent, isoform-selective, and CNS-penetrant NaV1.6 inhibitor (IC50=41 nM for hNaV1.6). XPC-6444 also displays potent block of NaV1.2 (IC50=125 nM). XPC-6444 shows anticonvulsant activity[1].

IC50 & Target

IC50: 41 nM (hNaV1.6), 125 nM (hNaV1.2)[1]

In Vitro

XPC-6444 shows high selectivity over NaV1.1 and NaV1.5[1].

In Vivo

XPC-6444 exhibits good metabolic stability in human liver microsomes and hepatocytes, and low potential for MDR1 mediated efflux[1].

Molecular Weight

498.58

Formula

C₂₂H₂₅F₃N₄O₂S₂

CAS No.

2230144-21-3

SMILES

O=S(C1=C(F)C=C(NCC2=C(F)C=CC=C2CN(C(C)(C)C)C)C=C1F)(NC3=CSC=N3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Keywords:

XPC-6444XPC6444XPC 6444Sodium ChannelNa channelsNa+ channelsInhibitorinhibitorinhibit

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