1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. Methocarbamol

Methocarbamol 

Cat. No.: HY-B0262 Purity: 98.39%
Handling Instructions

Methocarbamol is an orally active central muscle relaxant and blocks muscular Nav1.4 channel. Methocarbamol reversibly affects voltage dependence of inactivation of Nav1.4 channel. Methocarbamol has the potential for muscle spasms and pain syndromes research.

For research use only. We do not sell to patients.

Methocarbamol Chemical Structure

Methocarbamol Chemical Structure

CAS No. : 532-03-6

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Solution
10 mM * 1 mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 77 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 70 In-stock
Estimated Time of Arrival: December 31
500 mg USD 100 In-stock
Estimated Time of Arrival: December 31
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Description

Methocarbamol is an orally active central muscle relaxant and blocks muscular Nav1.4 channel. Methocarbamol reversibly affects voltage dependence of inactivation of Nav1.4 channel. Methocarbamol has the potential for muscle spasms and pain syndromes research[1][2][3].

IC50 & Target[3]

Nav1.4

 

In Vitro

Methocarbamol (2 mM; for 20 min) significantly increases the decay times of the EPCs and those of the EPPs induced by the phrenic nerve stimulation[3].
Methocarbamol has no effect on Nav1.7 currents[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Methocarbamol (200 mg/kg; ip) has Muscle relaxant activity of 88.96%[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice with weight 20-30 g[3]
Dosage: 200 mg/kg
Administration: IP; single dose
Result: Had Muscle relaxant activity of 88.96%.
Clinical Trial
Molecular Weight

241.24

Formula

C₁₁H₁₅NO₅

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (414.52 mM)

H2O : 4 mg/mL (16.58 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1452 mL 20.7262 mL 41.4525 mL
5 mM 0.8290 mL 4.1452 mL 8.2905 mL
10 mM 0.4145 mL 2.0726 mL 4.1452 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3.5 mg/mL (14.51 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3.5 mg/mL (14.51 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3.5 mg/mL (14.51 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Methocarbamol
Cat. No.:
HY-B0262
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