2230144-21-3
2230144-21-3
Chemical Structure
XPC-6444
- CAS No.: 2230144-21-3
- Formula:C22H25F3N4O2S2
- Molecular Weight:498.58
IUPAC Name: 4-((2-((tert-butyl(methyl)amino)methyl)-6-fluorobenzyl)amino)-2,6-difluoro-N-(thiazol-4-yl)benzenesulfonamide
InChIKey: VOJFVKGTRNXOTJ-UHFFFAOYSA-N
SMILES: O=S(C1=C(F)C=C(NCC2=C(F)C=CC=C2CN(C(C)(C)C)C)C=C1F)(NC3=CSC=N3)=O
Biological Activity: XPC-6444 is a highly potent, isoform-selective, and CNS-penetrant NaV1.6 inhibitor (IC50=41 nM for hNaV1.6). XPC-6444 also displays potent block of NaV1.2 (IC50=125 nM). XPC-6444 shows anticonvulsant activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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XPC-6444 | 98.93 | XPC-6444 is a highly potent, isoform-selective, and CNS-penetrant NaV1.6 inhibitor (IC50=41 nM for hNaV1.6). XPC-6444 also displays potent block of NaV1.2 (IC50=125 nM). XPC-6444 shows anticonvulsant activity. | ||||||||||||||||||||
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References
Keywords
