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Cat. No.: HY-U00086

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Darodipine

(Synonyms: PY 108-068; PY-108068)

Darodipine (PY 108-068, PY-108068) is a potent calcium channel antagonist.

For research use only. We do not sell to patients.

CAS No.: 72803-02-2
Formula: C₁₉H₂₁N₃O₅
Molecular Weight:371.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Darodipine Chemical Structure

CAS No.: 72803-02-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Protocol
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Darodipine (PY 108-068, PY-108068) is a potent calcium channel antagonist.

All Calcium Channel Isoforms :

In Vivo

Treatment with darodipine increases the number and the average length of alkaline phosphatase-reactive capillaries and reduces the intercapillary distance and the diameter of cerebral capillaries in old rats. The pericapillary microrenvironment of the Ammon’s horn is the most sensitive to treatment with darodipine^[1]. Darodipine may reduce neuronal cytoskeletal changes occurring in aging and in neurodegenerative disorders. A 6-month treatment (from the 18th to the 24th month of life) with an oral daily dose of 10 mg/kg of darodipine restores in part the expression of 200 kDa-NF subunit immunoreactivity in the cerebellar cortex^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 72803-02-2
Molecular Weight 371.39
Formula C₁₉H₂₁N₃O₅
SMILES

O=C(C1=C(C)NC(C)=C(C(OCC)=O)C1C2=CC=CC3=NON=C32)OCC
Synonyms

PY 108-068; PY-108068
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocol

Animal Administration^[1]

Rats: Male Wistar rats are used. Twelve-month-old rats are left untreated and used as adult reference animals. Twenty-one-month-old rats are allotted randomly to two groups of 8 animals each. Rats of the first group receive an oral daily dose of 5 mg/kg of darodipine in drinking water. The animals of the second group are left untreated and served as a control group. Rats of these two groups are allowed to survive for 6 months, until 27 months of age (old rats). Darodipine-treated rats have water consumption determined every second day and body weight determined weekly^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Amenta F, et al. Effect of long-term treatment with the dihydropyridine-type calcium channel blocker darodipine(PY 108-068) on the cerebral capillary network in aged rats. Mech Ageing Dev. 1995 Jan 31;78(1):27-37. [Content Brief]

[2]. Vega JA, et al. Effect of treatment with the dihydropyridine-type calcium antagonist darodipine (PY 108-068) on the expression of neurofilament protein immunoreactivity in the cerebellar cortex of aged rats. Mech Ageing Dev. 1994 Aug;75(2):169-77. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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