1. Stem Cell/Wnt
    TGF-beta/Smad
  2. Hippo (MST)
    TGF-beta/Smad
    Wnt
  3. EMT inhibitor-1

EMT inhibitor-1 

Cat. No.: HY-101275 Purity: 98.71%
Handling Instructions

EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.

For research use only. We do not sell to patients.

EMT inhibitor-1 Chemical Structure

EMT inhibitor-1 Chemical Structure

CAS No. : 1638526-21-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 495 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.

IC50 & Target

Hippo, TGF-β, Wnt[1].

In Vitro

EMT inhibitor-1 (C19) is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities, inhibiting cancer cell migration, proliferation, and resistance to doxorubicin in vitro[1].

In Vivo

EMT inhibitor-1 (C19) exerts strong antitumor activity in a mouse tumor model. Mechanistically, EMT inhibitor-1 induces GSK3-β–mediated degradation of the Hippo transducer TAZ, through activation of the Hippo kinases Mst/Lats and the tumor suppressor kinase AMPK upstream of the degradation complex[1].

Molecular Weight

319.21

Formula

C₁₂H₁₂Cl₂N₂O₂S

CAS No.

1638526-21-2

SMILES

OCCCCOC1=NSN=C1C2=CC=C(Cl)C(Cl)=C2

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (313.27 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1327 mL 15.6637 mL 31.3273 mL
5 mM 0.6265 mL 3.1327 mL 6.2655 mL
10 mM 0.3133 mL 1.5664 mL 3.1327 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.83 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.83 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.83 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.71%

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EMT inhibitor-1
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HY-101275
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