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Alkaloid

Alkaloids are a group of naturally occurring chemical compounds that mostly contain basic nitrogen atoms, produced by a large variety of organisms including bacteria, fungi, plants, and animals. This group also includes some related compounds with neutral and even weakly acidic properties. Compounds like amino acid peptides, proteins, nucleotides, nucleic acid, amines, and antibiotics are usually not called alkaloids. Alkaloids have a wide range of pharmacological activities including antimalarial, antiasthma, anticancer, cholinomimetic, vasodilatory, antiarrhythmic, analgesic, antibacterial, and antihyperglycemic activities. Many have found use in traditional or modern medicine, or as starting points for drug discovery. Other alkaloids possess psychotropic and stimulant activities, and have been used in entheogenic rituals or as recreational drugs. Alkaloids can be toxic too. Although alkaloids act on a diversity of metabolic systems in humans and other animals, they almost uniformly evoke a bitter taste.

Alkaloid (200):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-19312
    3-Methyladenine 5142-23-4 99.84%
    3-Methyladenine is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K.
    3-Methyladenine
  • HY-10448
    Capsaicin 404-86-4 98.39%
    Capsaicin is a TRPV1 agonist with an EC50 of 0.29 μM in HEK293 cells.
    Capsaicin
  • HY-N0488
    Vincristine sulfate 2068-78-2 99.51%
    Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of 85 nM.
    Vincristine sulfate
  • HY-16569
    Colchicine 64-86-8 99.56%
    Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM.
    Colchicine
  • HY-N0219
    (+)-Bicuculline 485-49-4 99.97%
    (+)-Bicuculline, a convulsant alkaloid, is the antagonist of GABA.
    (+)-Bicuculline
  • HY-10820A
    Pemetrexed disodium 150399-23-8 99.77%
    Pemetrexed disodium is a novel antifolate that inhibits the folatedependent enzymes thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase with Kis of 1.3, 7.2, and 65 nM, respectively.
    Pemetrexed disodium
  • HY-N0737A
    Harmine 442-51-3 99.58%
    Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase ((DYRK)) inhibitor with anticancer and anti-inflammatory activities.
    Harmine
  • HY-N0296A
    Scopolamine hydrobromide 114-49-8 >98.0%
    Scopolamine hydrobromide is a high affinity (nM) muscarinic antagonist. 5-HT3 receptor-responses are reversibly inhibited by Scopolamine with an IC50 of 2.09 μM.
    Scopolamine hydrobromide
  • HY-14944
    Homoharringtonine 26833-87-4 99.39%
    Homoharringtonine (Omacetaxine mepesuccinate;HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation.
    Homoharringtonine
  • HY-N2149
    Tomatidine 77-59-8 >98.0%
    Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling.
    Tomatidine
  • HY-N0127
    Yohimbine Hydrochloride 65-19-0 99.85%
    Yohimbine hydrochloride is an alpha 2-adrenoreceptor antagonist, blocking the pre- and postsynaptic alpha-2 adrenoreceptors and causing an increased release of noradrenaline and dopamine.
    Yohimbine Hydrochloride
  • HY-B0282
    Acetylcholine chloride 60-31-1 >98.0%
    Acetylcholine is a neurotransmitter that can induce the opening of calcium channels.
    Acetylcholine chloride
  • HY-N0086
    N6-Methyladenosine 1867-73-8 99.51%
    N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes.
    N6-Methyladenosine
  • HY-10572
    Efavirenz 154598-52-4 99.99%
    Efavirenz is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture.
    Efavirenz
  • HY-B0345A
    ATP disodium salt 987-65-5 >98.0%
    ATP Disodium salt is a P2 purinoceptor agonist.
    ATP disodium salt
  • HY-16563
    Narciclasine 29477-83-6 99.94%
    Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.
    Narciclasine
  • HY-13417A
    AICAR phosphate 681006-28-0 >98.0%
    AICAR phosphate is an activator of AMP-activated protein kinase (AMPK), down-regulates the insulin receptor expression in HepG2 cells.
    AICAR phosphate
  • HY-12048
    Chelerythrine Chloride 3895-92-9 >98.0%
    Chelerythrine Chloride is a potent, cell-permeable inhibitor of protein kinase C, with an IC50 of 660 nM, competitive with respect to the phosphate acceptor and non-competitive with respect to ATP.
    Chelerythrine Chloride
  • HY-N0304
    L-DOPA 59-92-7 99.72%
    L-DOPA is a natural form of DOPA used in the treatment of Parkinson's disease.
    L-DOPA
  • HY-B0117
    Tigecycline 220620-09-7 99.74%
    Tigecycline is a first-in-class, broad spectrum antibiotic with activity against antibiotic-resistant organisms.
    Tigecycline