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Alkaloid

Alkaloids are a group of naturally occurring chemical compounds that mostly contain basic nitrogen atoms, produced by a large variety of organisms including bacteria, fungi, plants, and animals. This group also includes some related compounds with neutral and even weakly acidic properties. Compounds like amino acid peptides, proteins, nucleotides, nucleic acid, amines, and antibiotics are usually not called alkaloids. Alkaloids have a wide range of pharmacological activities including antimalarial, antiasthma, anticancer, cholinomimetic, vasodilatory, antiarrhythmic, analgesic, antibacterial, and antihyperglycemic activities. Many have found use in traditional or modern medicine, or as starting points for drug discovery. Other alkaloids possess psychotropic and stimulant activities, and have been used in entheogenic rituals or as recreational drugs. Alkaloids can be toxic too. Although alkaloids act on a diversity of metabolic systems in humans and other animals, they almost uniformly evoke a bitter taste.

Alkaloid (407):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-19312
    3-Methyladenine 5142-23-4 99.84%
    3-Methyladenine is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K.
    3-Methyladenine
  • HY-15141
    Staurosporine 62996-74-1 99.98%
    Staurosporine is a potent and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively.
    Staurosporine
  • HY-10448
    Capsaicin 404-86-4 99.01%
    Capsaicin ((E)-Capsaicin) is a mixture of Capsaicin and Dihydrocapsaicin. Capsaici is a TRPV1 agonist with an EC50 of 0.29 μM in HEK293 cells.
    Capsaicin
  • HY-N0488
    Vincristine sulfate 2068-78-2 99.66%
    Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of 85 nM.
    Vincristine sulfate
  • HY-16560
    Camptothecin 7689-03-4 98.62%
    Camptothecin (Campathecin) is a potent DNA enzyme topoisomerase I inhibitor, with an IC50 of 679 nM.
    Camptothecin
  • HY-B0726
    Pilocarpine Hydrochloride 54-71-7 99.92%
    Pilocarpine Hydrochloride is a selective M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.
    Pilocarpine Hydrochloride
  • HY-16569
    Colchicine 64-86-8 99.98%
    Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM.
    Colchicine
  • HY-13704
    SN-38 86639-52-3 99.46%
    SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively.
    SN-38
  • HY-A0276
    Gentamicin sulfate 1405-41-0
    Gentamicin sulfate, an aminoglycoside antibiotic, inhibits the growth of both gram-positive and gram-negative bacteria and to inhibit several strains of mycoplasma in tissue culture. It inhibits DNase I with an IC50 of 0.57 mM.
    Gentamicin sulfate
  • HY-N0219
    (+)-Bicuculline 485-49-4 99.97%
    (+)-Bicuculline is a light-sensitive competitive antagonist of GABA-A receptor.
    (+)-Bicuculline
  • HY-N2149
    Tomatidine 77-59-8 >98.0%
    Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling.
    Tomatidine
  • HY-N0737A
    Harmine 442-51-3 99.78%
    Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM.
    Harmine
  • HY-N1150
    Thymidine 50-89-5 99.90%
    Thymidine, a pyrimidine deoxynucleoside, is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.
    Thymidine
  • HY-B0345A
    ATP disodium salt 987-65-5 >98.0%
    ATP disodium salt is a phosphate-group donor for substrate activation in metabolic reactions and the coenzyme for a large number of kinases.
    ATP disodium salt
  • HY-14944
    Homoharringtonine 26833-87-4 99.96%
    Homoharringtonine (Omacetaxine mepesuccinate;HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation.
    Homoharringtonine
  • HY-16563
    Narciclasine 29477-83-6 99.74%
    Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.
    Narciclasine
  • HY-13956
    Pioglitazone 111025-46-8 99.18%
    Pioglitazone (U 72107) is a potent and selective PPARγ agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively.
    Pioglitazone
  • HY-13780
    Vinblastine sulfate 143-67-9 99.85%
    Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM.
    Vinblastine sulfate
  • HY-N2019
    Chaetocin 28097-03-2 98.06%
    Chaetocin is a specific inhibitor of the histone methyltransferase (HMT) SU(VAR)3-9 with an IC50 of 0.6 μM for SU(VAR)3-9. It also inhibits thioredoxin reductase (TrxR) with an IC50 of 4 μM.
    Chaetocin
  • HY-B0282
    Acetylcholine chloride 60-31-1 >99.0%
    Acetylcholine chloride (ACh chloride) is a common neurotransmitter found in the central and peripheral nerve system.
    Acetylcholine chloride