1. Natural Products
  2. Alkaloid

Alkaloid

Alkaloids are a group of naturally occurring chemical compounds that mostly contain basic nitrogen atoms, produced by a large variety of organisms including bacteria, fungi, plants, and animals. This group also includes some related compounds with neutral and even weakly acidic properties. Compounds like amino acid peptides, proteins, nucleotides, nucleic acid, amines, and antibiotics are usually not called alkaloids. Alkaloids have a wide range of pharmacological activities including antimalarial, antiasthma, anticancer, cholinomimetic, vasodilatory, antiarrhythmic, analgesic, antibacterial, and antihyperglycemic activities. Many have found use in traditional or modern medicine, or as starting points for drug discovery. Other alkaloids possess psychotropic and stimulant activities, and have been used in entheogenic rituals or as recreational drugs. Alkaloids can be toxic too. Although alkaloids act on a diversity of metabolic systems in humans and other animals, they almost uniformly evoke a bitter taste.

Alkaloid (340):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-19312
    3-Methyladenine 5142-23-4 99.84%
    3-Methyladenine is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K.
    3-Methyladenine
  • HY-15141
    Staurosporine 62996-74-1 99.98%
    Staurosporine is a potent and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively.
    Staurosporine
  • HY-10448
    Capsaicin 404-86-4 98.39%
    Capsaicin ((E)-Capsaicin) is a TRPV1 agonist with an EC50 of 0.29 μM in HEK293 cells.
    Capsaicin
  • HY-N0488
    Vincristine sulfate 2068-78-2 99.66%
    Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of 85 nM.
    Vincristine sulfate
  • HY-B0726
    Pilocarpine Hydrochloride 54-71-7 99.92%
    Pilocarpine Hydrochloride is a selective M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.
    Pilocarpine Hydrochloride
  • HY-16569
    Colchicine 64-86-8 99.98%
    Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM.
    Colchicine
  • HY-N0219
    (+)-Bicuculline 485-49-4 99.97%
    (+)-Bicuculline is a light-sensitive competitive antagonist of GABA-A receptor.
    (+)-Bicuculline
  • HY-N0737A
    Harmine 442-51-3 99.78%
    Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase ((DYRK)) inhibitor with anticancer and anti-inflammatory activities.
    Harmine
  • HY-N2149
    Tomatidine 77-59-8 >98.0%
    Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling.
    Tomatidine
  • HY-N0296A
    Scopolamine hydrobromide 114-49-8 >98.0%
    Scopolamine hydrobromide is a high affinity (nM) muscarinic antagonist. 5-HT3 receptor-responses are reversibly inhibited by Scopolamine with an IC50 of 2.09 μM.
    Scopolamine hydrobromide
  • HY-B0345A
    ATP disodium salt 987-65-5 >98.0%
    ATP disodium salt is a phosphate-group donor for substrate activation in metabolic reactions and the coenzyme for a large number of kinases.
    ATP disodium salt
  • HY-14944
    Homoharringtonine 26833-87-4 99.96%
    Homoharringtonine (Omacetaxine mepesuccinate;HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation.
    Homoharringtonine
  • HY-13417A
    AICAR phosphate 681006-28-0 99.49%
    AICAR phosphate is an activator of AMP-activated protein kinase (AMPK).
    AICAR phosphate
  • HY-13780
    Vinblastine sulfate 143-67-9 99.85%
    Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM.
    Vinblastine sulfate
  • HY-16563
    Narciclasine 29477-83-6 99.94%
    Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.
    Narciclasine
  • HY-10820A
    Pemetrexed disodium 150399-23-8 99.77%
    Pemetrexed disodium is a novel antifolate that inhibits the folatedependent enzymes thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase with Kis of 1.3, 7.2, and 65 nM, respectively.
    Pemetrexed disodium
  • HY-N0674A
    Dehydrocorydaline chloride 10605-03-5 98.64%
    Dehydrocorydaline chloride is an alkaloidal that has anti-inflammatory and anti-cancer activities. Dehydrocorydaline chloride can elevate p38 MAPK activation.
    Dehydrocorydaline chloride
  • HY-B0282
    Acetylcholine chloride 60-31-1 >99.0%
    Acetylcholine (chloride) is a common neurotransmitter found in the central and peripheral nerve system.
    Acetylcholine chloride
  • HY-N0127
    Yohimbine Hydrochloride 65-19-0 99.85%
    Yohimbine Hydrochloride is an alpha 2-adrenoreceptor antagonist, blocking the pre- and postsynaptic alpha-2 adrenoreceptors and causing an increased release of noradrenaline and dopamine.
    Yohimbine Hydrochloride
  • HY-12048
    Chelerythrine Chloride 3895-92-9 >98.0%
    Chelerythrine Chloride is a potent, cell-permeable inhibitor of protein kinase C, with an IC50 of 660 nM.
    Chelerythrine Chloride