1. Cell Cycle/DNA Damage
    NF-κB
  2. PPAR

Pemafibrate (Synonyms: (R)-K-13675)

Cat. No.: HY-17618 Purity: 99.78%
Data Sheet SDS Handling Instructions

Pemafibrate is a novel selective PPARα modulator (SPPARMα) that has antihyperlipidaemic activity.

For research use only. We do not sell to patients.
Pemafibrate Chemical Structure

Pemafibrate Chemical Structure

CAS No. : 848259-27-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO $356 In-stock
1 mg $110 In-stock
5 mg $330 In-stock
10 mg $500 In-stock
25 mg $1000 In-stock
50 mg $1600 In-stock
100 mg $2400 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

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  • Technical Information

  • Purity & Documentation

  • References

Description

Pemafibrate is a novel selective PPARα modulator (SPPARMα) that has antihyperlipidaemic activity.

In Vitro

In primary human macrophages, pemafibrate promotes macrophage cholesterol efflux to HDL and exerts anti-inflammatory activities[1]. Pemafibrate is a novel selective peroxisome proliferator-activated receptor α modulator (SPPARMα) that possesses unique PPARα activity and selectivity, compared with placebo and fenofibrate in thosse with high triglyceride (TG) and low high-density lipoprotein cholesterol (HDL-C) levels[2].

In Vivo

Pemafibrate treatment decreases apoB secretion in chylomicrons by polarized Caco-2/TC7 intestinal epithelium cells and reduces triglyceride levels in apoE2KI mice. Pemafibrate treatment of hapoA-I tg mice increases plasma HDL cholesterol, apoA-I and stimulates RCT to feces. Pemafibrate also reduces markers of inflammation and macrophages in the aortic crosses as well as aortic atherosclerotic lesion burden in western diet-fed apoE2KI mice[1].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.0385 mL 10.1926 mL 20.3853 mL
5 mM 0.4077 mL 2.0385 mL 4.0771 mL
10 mM 0.2039 mL 1.0193 mL 2.0385 mL
Please refer to the solubility information to select the appropriate solvent.
Animal Administration
[1]

Pemafibrate is suspended in carboxymethyl cellulose.

Female homozygous human apoE2KI mice, which express human apoE2 instead of mouse apoE and display a human-like lipoprotein profile, are fed a western diet containing (wt/wt) 0.2% cholesterol and 21% fat for 9 weeks and treated for the last 2 weeks with fenofibrate (250 mpk) or pemafibrate (0.1 or 1mpk) or carboxymethyl cellulose (CMC, control) (n=10/group). Blood is collected after 4 h-fasting by sinus retroorbital puncture under isoflurane-induced anaesthesia for biochemical analysis. Mice are euthanized by cervical dislocation and liver, aortic arch and intestinal epithelium are removed and snap-frozen until further analysis. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

490.55

Formula

C₂₈H₃₀N₂O₆

CAS No.

848259-27-8

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Pemafibrate
Cat. No.:
HY-17618
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