1. Cell Cycle/DNA Damage
    NF-κB
  2. PPAR

BMS-687453 

Cat. No.: HY-10678 Purity: 99.70%
Data Sheet SDS Handling Instructions

BMS-687453 is a potent and selective PPARα agonist, with an EC50 of 10 nM for human PPARα and 410-fold selectivity vs human PPARγ in PPAR-GAL4 transactivation assays.

For research use only. We do not sell to patients.
BMS-687453 Chemical Structure

BMS-687453 Chemical Structure

CAS No. : 1000998-59-3

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $121 In-stock
5 mg $110 In-stock
10 mg $180 In-stock
25 mg $360 In-stock
50 mg $600 In-stock
100 mg $950 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

BMS-687453 is a potent and selective PPARα agonist, with an EC50 of 10 nM for human PPARα and 410-fold selectivity vs human PPARγ in PPAR-GAL4 transactivation assays. IC50 value: 10 nM (EC50) Target: PPAR in vitro: BMS-687453 shows negligible activity (EC50 for transactivation of >25 μM and efficacies of <15% of standard) against a panel of human nuclear hormone receptors, including PPARδ LXR and RXR. BMS-687453 as a potent, highly selective PPARalpha agonist with an excellent preclinical safety profile. [1] in vivo: BMS-687453 exhibits low plasma clearance in the mouse, rat, and monkey and moderate plasma clearance in the dog, and the volume of distribution ranged from 0.7 L/kg (rat) to 3.5 L/kg (cynomolgusmonkey),which is comparable to the total body water in the rat and greater than total body water in the mouse, dog, and monkey. The half-life of BMS-687453 ranges from 3 h in mouse to 12 h in cynomolgus monkeys. BMS-687453 also possesses excellent absolute oral bioavailability ranging from 58% (dog) to 91% (rat). Additionally, BMS-687453 has excellent pharmaceutical properties, with a crystalline aqueous solubility being 280 μg/mL atpH6.5, increasing to > 4 mg/mL at pH 7.9. [1]

References
Molecular Weight

444.86

Formula

C₂₂H₂₁ClN₂O₆

CAS No.

1000998-59-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 31 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
BMS-687453
Cat. No.:
HY-10678
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