Farnesyl Transferase
Ftase
Farnesyl transferase is a zinc-dependent enzyme that catalyzes the attachment of a farnesyl lipid group to the sulfur atom of a cysteine residue of numerous proteins involved in cell signaling including the oncogenic H-Ras protein. Farnesyl transferase regulates the activation of Ras protein and consequently affects intracellular signal transduction, cell growth and proliferation.
Farnesyl transferase is an essential enzyme at downstream of mevalonate (MVA) pathway. Farnesyl transferase catalyzes the farnesylmoieties of farnesyl pyrophosphate (FPP) coupled to Ras protein, which is dependent on farnesylation anchoring itself in membrane for its activity. Farnesyl transferase inhibitors are small-molecule inhibitors that selectively inhibit farnesylation of a number of intracellular substrate proteins such as Ras. Farnesyl transferase inhibitors represent a new class of agents that target signal transduction pathways responsible for the proliferation and survival of diverse malignant cell types.
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Farnesyl Transferase Related Products (97)
Related Products (97)
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Antibodies (1)
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(Rac)-Tipifarnib
0 ImagesCat. No.: HY-118426CAS No.: 192185-68-5Synonyms: (Rac)-IND 58359; (Rac)-R115777(Rac)-Tipifarnib ((Rac)-IND 58359; (Rac)-R115777) is a potent farnesyl protein transferase inhibitor that specifically targets the pro-tailation process of Ras proteins. (Rac)-Tipifarnib showed significant in vivo antitumor effects after oral administration to mice.
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Ftase inhibitor I
0 ImagesCat. No.: HY-128044CAS No.: 149759-96-6Synonyms: B581Ftase inhibitor I (B581) is a potent, selective and peptidomimetic farnesyl transferase (FTase) inhibitor. Ftase inhibitor I shows selectivity for FTase over geranylgeranyl isoprenoid (Ras-GG) or the fatty acid myristate (Myr-Ras).
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J-104118
0 ImagesCat. No.: HY-116595CAS No.: 172277-82-6J-104118 is a potent and orally active squalene synthase (SQS) inhibitor with an IC50 of 0.52 nM. J-104118 inhibits cholesterol synthesis in mice. J-104118 can be used for cholesterol-lowering research.
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J-104123
0 ImagesCat. No.: HY-124374CAS No.: 162037-54-9J-104123 is an inhibitor of squalene synthase with monocarboxylic acid structure. J-104123 can lower serum cholesterol level in dog models.
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Andrastin A
0 ImagesCat. No.: HY-129279CAS No.: 174232-42-9Andrastin A meroterpenoid compound, is a farnesyltransferase inhibitor. Andrastin A inhibits the efflux of anticancer compounds from multidrug-resistant cancer cells. Andrastin A can be isolated from Penicillium species.
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Incadronate disodium
0 ImagesCat. No.: HY-B2097CAS No.: 138330-18-4Synonyms: YM 175; BisphonalIncadronate disodium (YM 175) is a bisphosphonate with strong inhibitory activity on bone resorption. Incadronate disodium indirectly stimulates renal 25-hydroxyvitamin D-1-hydroxylase by increasing circulating parathyroid hormone. Incadronate disodium, a cholesterol-lowering agent, is a potent inhibitor of rat liver microsomal squalene synthase (Ki=57 nM). Incadronate disodium inhibits sterol biosynthesis in mouse macrophage J774 cells (IC50=64 μM). Incadronate disodium has the potential for malignant tumors research.
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FTI-249
0 ImagesCat. No.: HY-117524CAS No.: 161721-65-9FTI-249 is a farnesyl transferase inhibitor with an IC50 of 100-200 nM. FTI-249 acts as a linear competitive inhibitor targeting the peptide substrate of farnesyl transferase. FTI-249 is applicable for cancer research.
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L-731128
0 ImagesCat. No.: HY-123404CAS No.: 172722-09-7L-731128 is a novel alkyl citrate. L-731128 can be isolated as a minor component of Sporormiella intermedia (MF 5447, ATCC 20985) fermentations. L-731128 is a potent squalene synthase inhibitor, with an IC50 value of 767 nM.
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Kurasoin A
0 ImagesCat. No.: HY-N14820CAS No.: 182232-62-8Kurasoin A is a farnesyltransferase inhibitor.
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Andrastin B
0 ImagesCat. No.: HY-N13874CAS No.: 174232-43-0Andrastin C is a protein farnesyltransferase inhibitor. Andrastin C has a common androstane skeleton.
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Schizostatin
0 ImagesCat. No.: HY-N13888CAS No.: 163564-55-4Schizostatin is a squalene synthase inhibitor with an IC50 of 0.84 μM.
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Acetylgliotoxin
0 ImagesCat. No.: HY-183421CAS No.: 146016-64-0Synonyms: Gliotoxin monoacetateAcetylgliotoxin (Gliotoxin monoacetate) is a farnesyltransferase (FTase) inhibitor with an IC50 of 4.4 μM against human targets. Acetylgliotoxin inhibits the growth of fungal, bacterial, and viral pathogens; it binds to free protein thiols and induces ROS production. Acetylgliotoxin increases the survival rate of Caenorhabditis elegans infected with Candida albicans, but exhibits toxicity at higher concentrations. Acetylgliotoxin is applicable to research related to Candida albicans infections.
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Arglabin (Standard)
0 ImagesCat. No.: HY-16059RCAS No.: 84692-91-1Synonyms: (+)-Arglabin (Standard)Arglabin (Standard) is the analytical standard of Arglabin (HY-16059). This product is intended for research and analytical applications. Arglabin ((+)-Arglabin), a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor. Arglabin shows anti-inflammatory and antitumor activities. The antitumor activity of Arglabin proceeds through its inhibition of farnesyl transferase which leads to the activation of RAS proto-oncogene.
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BMS-187745
0 ImagesCat. No.: HY-16108CAS No.: 157126-18-6BMS-187745 is a squalene synthase inhibitor. BMS-187745 reduces cholesterol synthesis. BMS-187745 does not induce significant myotoxicity in skeletal muscle.
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Lonafarnib (Standard)
0 ImagesSynonyms: Sch66336 (Standard)Lonafarnib (Standard) (Sch66336 (Standard)) is the analytical standard of Lonafarnib (HY-15136). This product is intended for research and analytical applications. Lonafarnib (Sch66336) is an orally active, blood-brain barrier penetrant farnesyltransferase (FPTase) inhibitor. Lonafarnib increases the phosphorylation levels of Akt, CaMKII and CREB, upregulates BDNF expression in the hippocampus, elevates the content of α7nAChR on cell membranes, and blocks the isoprenylation of H-Ras. Lonafarnib repairs synapses and reverses spatial memory deficits in Aβ1-42 model mice. Lonafarnib inhibits RSV fusion and replication, and alleviates virus-induced lung injury. Lonafarnib activates the lysosomal and autophagic pathways, and reduces the phosphorylation and aggregation of tau. Lonafarnib acts synergistically with Sorafenib (HY-10201) to promote apoptosis, and inhibits the proliferation and invasion of melanoma cells. Lonafarnib inhibits the farnesylation of progerin, repairs nuclear membrane defects, and activates the cGAS-STING-STAT1 signaling pathway. Lonafarnib can be used in research related to diseases including Alzheimer's disease, viral infections, melanoma, and progeria.
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L-739749
0 ImagesCat. No.: HY-120044CAS No.: 156511-34-1L-739749 is a farnesyl transferase inhibitor. L-739749 inhibits the selective hypersensitivity of JMML cells to granulocyte-macrophage colony-stimulating factor (GM-CSF) by blocking the prenylation of Ras. L-739749 exhibits a strong inhibitory effect on the growth of primary human JMML cells in vitro.
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YM-53601 (Standard)
0 ImagesCat. No.: HY-100313ARCAS No.: 182959-33-7YM-53601 (Standard) is the analytical standard of YM-53601 (HY-100313A). This product is intended for research and analytical applications. YM-53601, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo. YM-53601 inhibits squalene synthase derived from human hepatoma cells with an IC50 of 79 nM. Lipid-lowering agent. YM-53601 is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation.
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Tipifarnib (Standard)
0 ImagesCat. No.: HY-10502RCAS No.: 192185-72-1Synonyms: IND 58359 (Standard); R115777 (Standard)Tipifarnib (Standard) is the analytical standard of Tipifarnib (HY-10502). This product is intended for research and analytical applications. Tipifarnib (IND 58359) binds to and inhibits farnesyltransferase (FTase) with an IC50 of 0.86 nM. Antineoplastic activity and antiparasitic activity.
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J 104871
0 ImagesCat. No.: HY-19301CAS No.: 191088-19-4Synonyms: J-104135J 104871 (J-104135) is a farnesyl pyrophosphate (FPP)-competitive farnesyltransferase (FTase) inhibitor. J 104871 inhibits rat brain FTase with an IC50 of 3.9 nM in the presence of farnesyl pyrophosphate (FPP).
