161721-65-9
161721-65-9
Chemical Structure
FTI-249
- CAS No.: 161721-65-9
- Formula:C15H23N3O3S2
- Molecular Weight:357.49
IUPAC Name: (4-(((R)-2-amino-3-mercaptopropyl)amino)benzoyl)-L-methionine
InChIKey: IPZVKZRBOSROBN-YPMHNXCESA-N
SMILES: CSCC[C@@H](C(O)=O)NC(C1=CC=C(C=C1)NC[C@@H](N)CS)=O
Biological Activity: FTI-249 is a farnesyl transferase inhibitor with an IC50 of 100-200 nM. FTI-249 acts as a linear competitive inhibitor targeting the peptide substrate of farnesyl transferase. FTI-249 is applicable for cancer research[1][2].
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FTI-249 | FTI-249 is a farnesyl transferase inhibitor with an IC50 of 100-200 nM. FTI-249 acts as a linear competitive inhibitor targeting the peptide substrate of farnesyl transferase. FTI-249 is applicable for cancer research. | |||||||||||||||||||||
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References
- [1]. Sebti SM, et al. Inhibition of Ras prenylation: a novel approach to cancer chemotherapy. Pharmacology & therapeutics. 1997;74(1):103-14. [Content Brief]
- [2]. Roskoski R, et al. Time-dependent inhibition of protein farnesyltransferase by a benzodiazepine peptide mimetic. Biochemistry. 2001 Aug 07;40(31):9329-35. [Content Brief]
Keywords
