174232-42-9
Chemical Structure
Andrastin A
- CAS No.: 174232-42-9
- Formula:C28H38O7
- Molecular Weight:486.60
IUPAC Name: methyl (3S,5R,8S,9R,10S,13R,14R)-3-acetoxy-10-formyl-4,4,8,12,13,16-hexamethyl-15,17-dioxo-1,2,3,4,5,6,7,8,9,10,13,15,16,17-tetradecahydro-14H-cyclopenta[a]phenanthrene-14-carboxylate
InChIKey: GRBXNADBNJGZRK-GJEDHNSHSA-N
SMILES: CC1=C[C@@]2([C@](C)(CC[C@@]3(C(C)([C@H](CC[C@]32C=O)OC(C)=O)C)[H])[C@@](C(OC)=O)([C@@]1(C4=O)C)C(C4C)=O)[H]
Biological Activity: Andrastin A meroterpenoid compound, is a farnesyltransferase inhibitor. Andrastin A inhibits the efflux of anticancer compounds from multidrug-resistant cancer cells. Andrastin A can be isolated from Penicillium species[1][2].
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Andrastin A | Andrastin A meroterpenoid compound, is a farnesyltransferase inhibitor. Andrastin A inhibits the efflux of anticancer compounds from multidrug-resistant cancer cells. Andrastin A can be isolated from Penicillium species. | |||||||||||||||||||||
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- [1]. Nielsen KF, et al. Andrastins A-D, Penicillium roqueforti Metabolites consistently produced in blue-mold-ripened cheese. J Agric Food Chem. 2005 Apr 20;53(8):2908-13. [Content Brief]
- [2]. Rojas-Aedo JF, et al. The Biosynthetic Gene Cluster for Andrastin A in Penicillium roqueforti. Front Microbiol. 2017 May 5;8:813. [Content Brief]
Keywords
