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Cat. No.: HY-16108

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BMS-187745

BMS-187745 is a squalene synthase inhibitor. BMS-187745 reduces cholesterol synthesis. BMS-187745 does not induce significant myotoxicity in skeletal muscle.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 157126-18-6
화학식: C₁₆H₁₉O₇PS
분자량:386.35

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

BMS-187745 Chemical Structure

CAS No.: 157126-18-6

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

BMS-187745 is a squalene synthase inhibitor. BMS-187745 reduces cholesterol synthesis. BMS-187745 does not induce significant myotoxicity in skeletal muscle^[1].

IC₅₀ & Target

Squalene Synthase^[1]

In Vitro

Protein/Amino Acid MetabolismLipid Metabolism

Protein/Amino Acid Metabolism

BMS-187745 (10-2000 μM; 48 h) does not induce significant myotoxicity (changes in protein synthesis, total protein or LDH release) in primary cultures of neonatal rat skeletal muscle cells at concentrations up to 1000 μM, with only mild irreversible cytotoxicity observed at the highest tested concentration of 2000 μM^[1].

Lipid Metabolism

BMS-187745 (0.1-100 μM) potently inhibits de novo cholesterol synthesis in primary cultures of neonatal rat skeletal muscle cells, with an IC₅₀ of 6.9 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 157126-18-6
분자량 386.35
화학식 C₁₆H₁₉O₇PS
SMILES

O(C1=CC(CCC[C@@H](P(=O)(O)O)S(=O)(=O)O)=CC=C1)C2=CC=CC=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Flint OP, et al. Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro. Toxicology and applied pharmacology. 1997 Jul;145(1):91-8. [Content Brief]

[2]. Sun C Q, et al. A general synthesis of dioxolenone prodrug moieties[J]. Tetrahedron Letters, 2002, 43(7): 1161-1164.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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