GABA Receptor
Gamma-aminobutyric acid Receptor; γ-Aminobutyric acid Receptor
GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory neurotransmitter in the vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors), whereas GABAB receptors are G protein-coupled receptors (also known asmetabotropic receptors). It has long been recognized that the fast response of neurons to GABA that is blocked by bicuculline and picrotoxin is due to direct activation of an anion channel. This channel was subsequently termed the GABAA receptor. Fast-responding GABA receptors are members of family of Cys-loop ligand-gated ion channels. A slow response to GABA is mediated by GABAB receptors, originally defined on the basis of pharmacological properties.
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GABA Receptor Inhibitors
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GABA Receptor Antagonists
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GABA Receptor Activators
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GABA Receptor Controls
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GABA Receptor Ligands
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GABA Receptor Related Products (777)
Related Products (777)
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Antibodies (14)
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Related Compound Screening Libraries (1)
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GABA receptor antagonist 2
0 ImagesCat. No.: HY-175190CAS No.: 2922115-20-4GABA receptor antagonist 2 (Compound IId) is a GABA receptor antagonist with a LC50 of 0.0735 μg/mL for Plutella xylostella (P. xylostella). GABA receptor antagonist 2 has significant insecticidal activities against P. xylostella and its resistant strain, and Spodoptera frugiperda, and Chilo suppressalis. GABA receptor antagonist 2 binds the GABA receptor at the site of Drosophila RdlG335. GABA receptor antagonist 2 can be used to manage resistant pest populations.
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GABAA receptor modulator-5
0 ImagesCat. No.: HY-161784CAS No.: 3021554-08-2GABAA receptor modulator-5 (Compound S28) is a modulator for (γ-aminobutyric acid)A receptor (GABAA receptor), with EC50 of 56 nM and 10 nM, for α1β2γ2 and α4β3δ subtype. GABAA receptor modulator-5 exhibits good pharmacokinetic characteristics in rats. GABAA receptor modulator-5 is slightly toxic toxicity in rats with a loss of rollover reflex (LORR) threshold dose of 23.3 μmol/kg, and exhibits potential ameliorating the postpartum depression.
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GABAA receptor modulator-11
0 ImagesCat. No.: HY-178782GABAA receptor modulator-11 (Compound 4) is a GABAA receptor modulator. GABAA receptor modulator-11 inhibits anesthetic-induced desensitization of GABAA α1β3γ2 and α1β3 receptors, with IC50 values of 5.1 μM and 3.1 μM, respectively. GABAA receptor modulator-11 can be used for research on central nervous system diseases.
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Bicuculline methobromide
0 ImagesCat. No.: HY-100783BCAS No.: 66016-70-4Synonyms: (+)-Bicuculline methobromideBicuculline methobromide is a selective GABAA Receptor antagonist with an IC50 value of 3 μM. Bicuculline methobromide induces clonic tonic convulsions in mammals and can also be used to block Ca2+ activated potassium channels. Bicuculline methobromide can be used in studies of epilepsy and other related psychiatric disorders.
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Etiocholanolone (Standard)
0 ImagesSynonyms: 5β-Androsterone (Standard)Cimbuterol (Standard) is the analytical standard of Cimbuterol. This product is intended for research and analytical applications. Cimbuterol is a β-adrenergic receptor agonist.
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CMPPE
0 ImagesCat. No.: HY-134912CAS No.: 841253-81-4CMPPE is a GABAB receptor positive allosteric modulator (PAM) that inhibits alcohol self-administration and reinstatement behavior in rats.
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Baclofen-d4-1
0 ImagesCat. No.: HY-W707498CAS No.: 70155-52-1Baclofen-d4-1 is the deuterium labeled Baclofen (HY-B0007). Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABAB receptor (GABABR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABAB receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research.
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CGP 54626
0 ImagesCat. No.: HY-130670CAS No.: 149936-58-3CGP 54626 is a GABAB receptor modulator, which is essential in the central and peripheral nervous systems. It is used as a tool to identify and characterize GABAB receptor agonists and antagonists, which will aid in the development of drugs targeting diseases related to these systems. This discovery involves purified GABAB receptors, receptor proteins and their encoding nucleic acids, facilitating the study of new members of the GABAB receptor family through DNA cloning technology and sequence-derived probes.
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PWZ-029
0 ImagesCat. No.: HY-117560CAS No.: 164025-33-6PWZ-029 is a selective inverse agonist for 5 GABAA receptors. PWZ-029 is a benzodiazepine site ligand. PWZ-029 shows a weak but significant partial agonistic effect at 1- and 3-containing receptors. PWZ-029 significantly increases retention session latency in mouse fibroblast cells. PWZ-029 can improve object recognition in normal and scopolamine-treated rat model.
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GABAA receptor modulator-2
0 ImagesCat. No.: HY-147657CAS No.: 2413850-54-9GABAA receptor modulator-2 (Compound 20) is selective, orally active α5-GABAAR negative allosteric modulator (NAM) with a Ki of 4.1 nM. GABAA receptor modulator-2 shows high-metabolic stability and good CNS safety.
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TETS-4-Methylaniline
0 ImagesCat. No.: HY-155498CAS No.: 2107375-55-1TETS-4-Methylaniline (compound 2k) is a hapten. TETS-4-Methylaniline conjugates to the carrier protein via using either diazotization or glutaraldehyde methods.
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γ-Aminobutyric acid-15N
0 ImagesCat. No.: HY-N0067S4CAS No.: 58485-43-1Synonyms: 4-Aminobutyric acid-15Nγ-Aminobutyric acid-15N (4-Aminobutyric acid-15N) is the 15N-labeled γ-Aminobutyric acid (HY-N0067). γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain, binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors. γ-Aminobutyric acid shows calming effect by blocking specific signals of central nervous system.
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DPNI-GABA
0 ImagesCat. No.: HY-103526CAS No.: 927866-58-8DPNI-GABA is a nitroindoline cage compound that inhibits GABA(A) receptors and reduces GABA-evoked peak responses with an IC50 value of 0.5 mM.
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GABAA receptor modulator-8
0 ImagesCat. No.: HY-173616CAS No.: 2889382-34-5GABAA receptor modulator-8 (10c) is a blood-brain barrier penetrated, selective and positive modulator of GABAA receptor, with excellent antiepileptic activity.
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Homocarnosine-15N3 TFA
0 ImagesCat. No.: HY-114883BSSynonyms: L-Homocarnosine-15N3 TFAHomocarnosine-15N3 (L-Homocarnosine-15N3) TFA is the 15N-labeled Homocarnosine (HY-114883). Homocarnosine is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects.Homocarnosine has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation.
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mNLS-CPP-scramble
0 ImagesCat. No.: HY-P11208AmNLS-CPP-scramble is a negative control peptide of mNLS-CPP-WSTF. mNLS-CPP-scramble is promising for research of chronic inflammatory diseases (e.g., MASH, osteoarthritis).
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Carbromal (Standard)
0 ImagesSynonyms: Adalin (Standard); Adisomnol (Standard); Bromacetocarbamide (Standard)Carbromal (Standard) is the analytical standard of Carbromal. This product is intended for research and analytical applications. Carbromal (Adalin; Adisomnol) is a sedative with centrally depressant effects.
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17-PA
0 ImagesCat. No.: HY-103495CAS No.: 694438-95-417-PA is a selective antagonist of neurosteroid potentiation and direct gating of GABAA receptors.
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Imidazoleacetic acid hydrochloride (Standard)
0 ImagesSynonyms: Imidazolyl-4-acetic acid hydrochloride (Standard)Imidazoleacetic acid (hydrochloride) (Standard) is the analytical standard of Imidazoleacetic acid (hydrochloride). This product is intended for research and analytical applications. Imidazoleacetic acid hydrochloride is a γ-aminobutyric acid receptor agonist. Imidazoleacetic acid hydrochloride inhibits GABA-T in a non-competitive manner, with a Ki value of 0.34 mM. Imidazoleacetic acid hydrochloride increases total free GABA in brain[1][2][3].
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Topiramate D12 (Standard)
0 ImagesCat. No.: HY-110234RCAS No.: 1279037-95-4Synonyms: McN 4853 D12 (Standard); RWJ 17021 D12 (Standard)Topiramate D12 (Standard) is the analytical standard of Topiramate D12. This product is intended for research and analytical applications. Topiramate D12 (McN 4853 D12) is a deuterium labeled Topiramate. Topiramate is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase.
