GABAA receptor modulator-8
GABAA receptor modulator-8 (10c) is a blood-brain barrier penetrated, selective and positive modulator of GABAA receptor, with excellent antiepileptic activity.
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- CAS No.: 2889382-34-5
- Formule: C20H17FN4O
- Masse moléculaire:348.37
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
Description
Parmacokinetics
| Species | Dose | Route | Tmax | Plasma Concentration | T1/2 | MRT | AUC | Bioavailability |
|---|---|---|---|---|---|---|---|---|
| Rat[1] | 10 mg/kg | i.g. | 4 h | 587.67±12.66 ng/mL | 2.53±0.12 h | 4.57±0.09 h | 3201.38±82.07 ng/L.h | 9.34±0.07 % |
| Rat[1] | 10 mg/kg | i.v. | / | / | 2.47±0.14 h | 3.65±0.30 h | 34,263.98±1100.87 ng/L.h | / |
| Rat[1] | 30 mg/kg | i.g. | 4 h | 1521.25±100.76 ng/mL | 2.57±0.09 h | 5.37±0.32 h | 11,273.22±703.84 ng/L.h | 10.47±0.10 % |
| Rat[1] | 30 mg/kg | i.v. | / | / | 2.49±0.07 h | 3.86±0.06 h | 107,689.72±6779.70 ng/L.h | / |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2889382-34-5
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Masse moléculaire 348.37
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Formule C20H17FN4O
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SMILES
CCCOC1=CC(C2=CC=CC=C2)=NC3=NC(C4=C(F)C=CC=C4)=NN13
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GABAA receptor modulator-8 Related Classifications
HY-173616 Related Classifications
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