2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. GABAA receptor modulator-2

GABAA receptor modulator-2 (Compound 20) is selective, orally active α5-GABAAR negative allosteric modulator (NAM) with a Ki of 4.1 nM. GABAA receptor modulator-2 shows high-metabolic stability and good CNS safety.

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GABAA receptor modulator-2 Chemical Structure

GABAA receptor modulator-2 Chemical Structure

CAS No. : 2413850-54-9

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GABAA receptor modulator-2 Related Antibodies

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Description

GABAA receptor modulator-2 (Compound 20) is selective, orally active α5-GABAAR negative allosteric modulator (NAM) with a Ki of 4.1 nM. GABAA receptor modulator-2 shows high-metabolic stability and good CNS safety[1].

IC50 & Target

Ki: 4.1 nM (hα5)[1]
In Vivo

GABAA receptor modulator-2 (Compound 20) (0-10 mg/kg) produces a dose-dependent reversal of the PCP-induced cognitive deficit in the rat subPCP NOR test[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

459.49

Formula

C22H22FN3O5S
CAS No.
SMILES

CC1=C(C(C2=CC=C(C=C2)F)=NO1)COC3=NC4=C(C=C3)CN(C(CS(C)(=O)=O)=O)CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GABAA receptor modulator-2 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GABAA receptor modulator-22413850-54-9GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorcentral nervous systemCNSmetabolic stabilityInhibitorinhibitorinhibit

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