Lipase
Lipase is a water-soluble enzyme that can catalyze the ester bond hydrolysis of lipids, decompose and metabolize fat molecules. Lipase is produced primarily by the pancreas and helps the body digest fats and oils. Lipase inhibitors are able to reduce the digestion and absorption of fat, thereby reducing collective caloric intake and weight loss. Lipase inhibitors are commonly used to suppress diseases such as obesity, hyperlipidemia, and pancreatitis.
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Lipase Related Products (123)
Related Products (123)
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Antibodies (6)
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Poly(3-hydroxybutyrate)
0 ImagesCat. No.: HY-206972CAS No.: 26063-00-3Poly (3-hydroxybutyrate) is a bacterially derived (R)-3-hydroxybutyrate homopolymer and a degradable biomaterial. Poly (3-hydroxybutyrate) degrades in vivo via lipases and esterases, breaking down into 3-Hydroxybutyric acid (HY-113378). Poly (3-hydroxybutyrate) can be compounded with 15% Hydroxyapatite (HA) (HY-D0835A) or 7.5-10% nanobioglass for use as a bone scaffold.
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Platycodin V
0 ImagesCat. No.: HY-N16617CAS No.: 91095-81-7Platycodin V is a triterpenoid saponin. Platycodin V has a relatively weak inhibitory effect on pancreatic lipase.
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3'-O-Methy isosaponarin
0 ImagesCat. No.: HY-N17996CAS No.: 2803327-85-53'-O-Methylisosaponarin is a spsoscoparin glycoside found in the leaves of C. sativus cultivar Chinese Yellow. 3'-O-Methylisosaponarin shows weak anti-lipase activity. 3'-O-Methylisosaponarin can be used for the research of disturbances of lipid metabolism.
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Lipstatin (Standard)
0 ImagesCat. No.: HY-N2330RCAS No.: 96829-59-3Ginsenoside F2 (Standard) is the analytical standard of Ginsenoside F2. This product is intended for research and analytical applications. Ginsenoside F2, a metabolite from Ginsenoside Rb1, induces apoptosis accompanied by protective autophagy in breast cancer stem cells.
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Ro 20-0083
0 ImagesCat. No.: HY-182262CAS No.: 31478-25-8
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MEDI-5884
0 ImagesCat. No.: HY-P991574CAS No.: 2643310-75-0Synonyms: REG-101MEDI-5884 (REG-101) is a humanized IgG4Pκ neutralizing monoclonal antibody targeting endothelial lipase (EL), with an IC50 of 1.3 nM and 1.7 nM against human and cynomolgus monkey EL, respectively; its Kd values for human and cynomolgus monkey EL are 4.1 nM and 1.6 nM, respectively. MEDI-5884 increases plasma levels of HDL-C, apolipoprotein A1 (ApoA1) and phospholipids, while causing a slight increase in LDL-C and apolipoprotein B (ApoB) levels. MEDI-5884 can be used in research related to cardiovascular diseases, coronary heart disease, coronary atherosclerosis and stable coronary artery disease.
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4,6,12-Tetradecatriene8,10-diyne-1,3-diacetate
0 ImagesCat. No.: HY-N7988CAS No.: 23414-61-14,6,12-Tetradecatriene8,10-diyne-1,3-diacetate is a polyacetylene compound found in the rhizomes of Atractylodes lancea. 4,6,12-Tetradecatriene8,10-diyne-1,3-diacetate inhibits human pancreatic lipase, with an IC50 of 55.67 μM and 16.7 μg/mL. 4,6,12-Tetradecatriene8,10-diyne-1,3-diacetate can block the digestion of triglycerides by inhibiting the activity of human pancreatic lipase. 4,6,12-Tetradecatriene8,10-diyne-1,3-diacetate can be used in research on obesity.
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Mogroside IV (Standard)
0 ImagesCat. No.: HY-N6945RCAS No.: 89590-95-4Mogroside IV (Standard) is the analytical standard of Mogroside IV (HY-N6945). This product is intended for research and analytical applications. Mogroside IV is a pancreatic lipase inhibitor with a IC50 of 289.09 µg/mL. Mogroside IV inhibits pancreatic lipase in a dose-dependent manner. Mogroside IV can be used in research related to obesity.
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Ciwujianoside C1
0 ImagesCat. No.: HY-N12298CAS No.: 114906-73-9Ciwujianoside C1 is a saponin, that can be isolated from the leaves of Acanthopanax senticosus. Ciwujianoside C1 inhibits pancreatic lipase activity in vitro.
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Salacinol
0 ImagesCat. No.: HY-119741CAS No.: 200399-47-9Salacinol, compound found in Salacia reticulata, is an orally active α-glucosidase/lipase inhibitor. Salacinol inhibits enzymatic activity of intestinal maltase (IC50 = 3.2 μg/mL, Ki = 0.31 μg/mL), sucrase (IC50 = 0.84 μg/mL, Ki = 0.32 μg/mL), and isomaltase (IC50 = 0.59 μg/mL, Ki = 0.47 μg/mL), and inhibits increases in serum glucose levels in sucrose-loaded rats. Salacinol also inhibits pancreatic lipase and lipoprotein lipase. Salacinol can be used for the research of diabetes mellitus.
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SMP-028
0 ImagesCat. No.: HY-19861CAS No.: 914389-14-3SMP-028 is an inhibitor of neutral cholesterol esterase (CEase), with an IC50 of 1.01 μM.
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Esterastin
0 ImagesCat. No.: HY-N14194CAS No.: 67655-93-0Esterastin is a lipase inhibitor with an IC50 value of 2 ng/mL when p-nitrophenyl acetate is used as a substrate.
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ERX-208
0 ImagesCat. No.: HY-181986CAS No.: 2440087-57-8ERX-208 is an anticancer agent that induces endoplasmic reticulum stress by targeting lysosomal acid lipase A (LIPA), ultimately leading to cancer cell apoptosis. ERX-208 can be used in ovarian cancer research.
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GSK264220A (Standard)
0 ImagesCat. No.: HY-103372RCAS No.: 685506-42-7GSK264220A (Standard) is the analytical standard of GSK264220A (HY-103372). This product is intended for research and analytical applications. GSK264220A is a potent endothelial lipase inhibitor with IC50 of 16 nM. GSK264220A has the potential to decrease the risk of cardiovascular disease.
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Stearidonoyl glycine
0 ImagesCat. No.: HY-175470CAS No.: 1874229-27-2Stearidonoyl glycine is an N-acyl amino acid. Stearidonoyl glycine has a weak potentiating effect on some glycine receptor subtypes, among which the potentiation on GlyRα2 is statistically significant.
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1-Isomangostin
0 ImagesCat. No.: HY-N8362CAS No.: 19275-44-6
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1,3-Didecanoylglycerol
0 ImagesCat. No.: HY-149506CAS No.: 17598-93-5Synonyms: 1,3-Dicaprin1,3-Didecanoylglycerol (1,3-Dicaprin) is a triglyceride analog that can be used as a substrate in pancreatic lipase hydrolysis reactions.
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KT195
0 ImagesCat. No.: HY-18542CAS No.: 1402612-58-1KT195 is a serine hydrolase inhibitor that targets ABHD6 (IC50 = 10 nM) and ABHD2, with no significant activity against DAGLβ. KT195 inhibits endoplasmic reticulum calcium release and mitochondrial calcium uptake by targeting ABHD2, thereby blocking A23187 (HY-N6687) and H2O2-induced necrotic cell death and apoptosis. By inhibiting ABHD6 activity, KT195 significantly induces 2-AG accumulation in Neuro2A cells and reduces IL-1β secretion in lipopolysaccharide-treated macrophages. KT195 has been used as a negative control probe for DAGLβ and can be applied in studies of ABHD6 and ABHD2 in calcium signaling, lipid metabolism, neuronal function, and inflammatory.
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Sclerodione
0 ImagesCat. No.: HY-N12893CAS No.: 104855-19-8Sclerodione is a metabolite that can be produced by the Scleroderris canker fungus, Gremmeniellaabietina. Sclerodione has antifungal activity. Sclerodione is a lipase inhibitor (IC50: 1 μM).
