96829-59-3
96829-59-3
Chemical Structure
Lipstatin
- CAS No.: 96829-59-3
- Formula:C29H49NO5
- Molecular Weight:491.70
IUPAC Name: (S)-(S,4Z,7Z)-1-((2S,3S)-3-hexyl-4-oxooxetan-2-yl)trideca-4,7-dien-2-yl 2-formamido-4-methylpentanoate
InChIKey: OQMAKWGYQLJJIA-CUOOPAIESA-N
SMILES: CC(C)C[C@@H](C(O[C@H](C[C@@H]([C@@H]1CCCCCC)OC1=O)C/C=C\C/C=C\CCCCC)=O)NC=O
Biological Activity: Lipstatin is a pancreatic lipase inhibitor (IC50=0.14 μM), whose structure is closely related to the known inhibitor, Esterastin. Lipstatin inhibits the absorption of triglycerides without affecting the absorption of oleic acid. Lipstatin has no inhibitory effects on other pancreatic enzymes, such as phospholipase A2 and trypsin (<200 μM)[1][2].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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Lipstatin | 80.0% | Lipstatin is a pancreatic lipase inhibitor (IC50=0.14 μM), whose structure is closely related to the known inhibitor, Esterastin. Lipstatin inhibits the absorption of triglycerides without affecting the absorption of oleic acid. Lipstatin has no inhibitory effects on other pancreatic enzymes, such as phospholipase A2 and trypsin (<200 μM). | ||||||||||||||||||||
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Lipstatin (Standard) | ≥98% | Lipstatin (Standard) is the analytical standard of Lipstatin (HY-N2330). This product is intended for research and analytical applications. Lipstatin is a pancreatic lipase inhibitor (IC50=0.14 μM), whose structure is closely related to the known inhibitor, Esterastin. Lipstatin inhibits the absorption of triglycerides without affecting the absorption of oleic acid. Lipstatin has no inhibitory effects on other pancreatic enzymes, such as phospholipase A2 and trypsin (<200 μM). | ||||||||||||||||||||
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L-Isoleucine orlistat | L-Isoleucine orlistat is a tetrahydrostatin analog and a selective inhibitor of diacylglycerol lipase α (DAGLα), with IC50 < 50 nM. L-Isoleucine orlistat has potential for research on neural signaling and inflammation-related diseases. | |||||||||||||||||||||
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Valilactone | 98.2% | Valilactone is a potent and effective inhibitor of esterase, produced by actinomycetes. | ||||||||||||||||||||
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α/β-Hydrolase-IN-1 | α/β-Hydrolase-IN-1 exhibits the best-in-class MICs of 50 μM (25 μg/mL) and 16 μM (8.4 μg/mL) against M. smegmatis and M. tuberculosis H37Ra, respectively. | |||||||||||||||||||||
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(R,S,S,S)-Orlistat | (R,S,S,S)-Orlistat is a stereogenic derivative of orlistat (tetrahydrolipstatin; THL) (HY-B0218). (R,S,S,S)-Orlistat inhibits three Mycobacterium tuberculosis lipid esterases, Ag85C (KI: 16.43 μM), Rv3802 (EC50: 16.2 nM), and Pks13-TE. | |||||||||||||||||||||
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Orlistat | 99.94% | Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN), is used orally for long-term research of obesity. Anti-atherosclerotic effect. | ||||||||||||||||||||
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Orlistat-d3 | Orlistat-d3 is a deuterated labeled Orlistat. Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN), is used orally for long-term research of obesity.?Anti-atherosclerotic?effect. | |||||||||||||||||||||
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Esterastin | Esterastin is a lipase inhibitor with an IC50 value of 2 ng/mL when p-nitrophenyl acetate is used as a substrate. | |||||||||||||||||||||
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Panclicin A | Panclicin A is a potent pancreatic lipase inhibitor. | |||||||||||||||||||||
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Panclicin B | Panclicin B is a potent pancreatic lipase inhibitor. | |||||||||||||||||||||
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Panclicin C | Panclicin C is a potent pancreatic lipase inhibitor. | |||||||||||||||||||||
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References
- [1]. Hochuli E, et al. Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. II. Chemistry and structure elucidation. J Antibiot (Tokyo). 1987 Aug;40(8):1086-91. [Content Brief]
- [2]. Weibel EK, et al. Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity. J Antibiot (Tokyo). 1987 Aug;40(8):1081-5. [Content Brief]
