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Cat. No.: HY-182262

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Ro 20-0083

Ro 20-0083 is an orally active pancreatic lipase inhibitor. Ro 20-0083 inhibits hPancreatic lipase activity, reduces lipid absorption and de novo fatty acid synthesis. Ro 20-0083 decreases food intake in Zucker rats. Ro 20-0083 can be used in obesity-related research.

For research use only. We do not sell to patients.

CAS No.: 31478-25-8
Formula: C₃₃H₅₁N₂NaO₁₀
Molecular Weight:658.76

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Ro 20-0083 Chemical Structure

CAS No.: 31478-25-8

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
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References
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Biological Activity

Description

In Vitro

Ro 20-0083 inhibits human pancreatic lipase in an in vitro assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ro 20-0083 (240 mg/kg body weight; p.o. via diet admixture) produces a significant, dose-matched anorectic effect in both obese and lean male Zucker rats, reducing 24-hour food intake by 56-72%^[1].
Chronic administration of Ro 20-0083 (250 mg/kg) reduces body weight gain, as well as decreases body fat and triglyceride levels, in obese female Zucker rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 31478-25-8
Molecular Weight 658.76
Formula C₃₃H₅₁N₂NaO₁₀
SMILES

CC[C@]1([C@]2([H])O[C@H]([C@@](CC2)(O[Na])CC)C)O[C@]([C@H](C1)C)([H])[C@@H](CC)C([C@@H](C)[C@@H](O)[C@H](C)CCC3=C(C(O)=C(C=C3[N+]([O-])=O)C)[N+]([O-])=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Drewnowski A, et al. Effects of inhibitors of carbohydrate absorption or lipid metabolism on meal patterns of Zucker rats. Pharmacol Biochem Behav. 1985;23(5):811-821. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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