Ro 20-0083 

Ro 20-0083 is an orally active pancreatic lipase inhibitor. Ro 20-0083 inhibits hPancreatic lipase activity, reduces lipid absorption and de novo fatty acid synthesis. Ro 20-0083 decreases food intake in Zucker rats. Ro 20-0083 can be used in obesity-related research^[1].

Ro 20-0083 inhibits human pancreatic lipase in an in vitro assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ro 20-0083 (240 mg/kg body weight; p.o. via diet admixture) produces a significant, dose-matched anorectic effect in both obese and lean male Zucker rats, reducing 24-hour food intake by 56-72%^[1].
Chronic administration of Ro 20-0083 (250 mg/kg) reduces body weight gain, as well as decreases body fat and triglyceride levels, in obese female Zucker rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

658.76

C₃₃H₅₁N₂NaO₁₀

31478-25-8

CC[C@]1([C@]2([H])O[C@H]([C@@](CC2)(O[Na])CC)C)O[C@]([C@H](C1)C)([H])[C@@H](CC)C([C@@H](C)[C@@H](O)[C@H](C)CCC3=C(C(O)=C(C=C3[N+]([O-])=O)C)[N+]([O-])=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Drewnowski A, et al. Effects of inhibitors of carbohydrate absorption or lipid metabolism on meal patterns of Zucker rats. Pharmacol Biochem Behav. 1985;23(5):811-821.  [Content Brief]