Lipase
Lipase is a water-soluble enzyme that can catalyze the ester bond hydrolysis of lipids, decompose and metabolize fat molecules. Lipase is produced primarily by the pancreas and helps the body digest fats and oils. Lipase inhibitors are able to reduce the digestion and absorption of fat, thereby reducing collective caloric intake and weight loss. Lipase inhibitors are commonly used to suppress diseases such as obesity, hyperlipidemia, and pancreatitis.
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Lipase Related Products (123)
Related Products (123)
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Antibodies (6)
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BemPPOX
0 ImagesCat. No.: HY-114754CAS No.: 1998101-23-7BemPPOX is an orally active, potent dog gastric lipase (DGL) inhibitor with Xl50 (the inhibitor molar excess leading to 50% lipase inhibition) of 0.5. BemPPOX is also a good inhibitor of GPLRP2 (xl50=0.64). BemPPOX efficiently regulates the gastrointestinal lipolysis and slows down the overall lipolysis process in rats. BemPPOX has the potential for obesity research.
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Fucoxanthinol
0 ImagesFucoxanthinol, a carotenoid, is a deacetylated Fucoxanthin (HY-N2302) metabolite with oral activity, and inhibits rat pancreatic lipase with an IC50 of 764 nM. Fucoxanthinol reduces expression of Bcl-2, Bcl-xL, survivin, XIAP, cIAP2, cyclin D1, cyclin D2, cyclin E, CDK4, CDK6, β-catenin, JunD, PPARγ, and induces GADD45α expression. Fucoxanthinol activates caspase-3, caspase-8, caspase-9, Nrf2/Keap1/ARE pathway, and inhibits activation of Akt, NF-κB, AP-1, PDPK1, GSK3β phosphorylation. Fucoxanthinol induces apoptosis, G0/G1 cell cycle arrest, inhibits cancer cell viability, proliferation, migration, invasiveness, tumour growth, adipocyte differentiation, oxidative stress, neurotoxicity, triglyceride absorption, angiogenesis, and obesity-induced inflammation. Fucoxanthinol can be used for the research of osteosarcoma, leukemia, lymphoma, adult T-cell leukemia, prostate cancer, colon cancer, breast cancer, hypertriglyceridaemia, Alzheimer’s disease, Parkinson’s disease, obesity, insulin resistance, malignant melanoma, and type II diabetes.
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Vulgarin
0 ImagesVulgarin is an orally active, naturally occurring eudesmane sesquiterpene with multiple biological activities including anti-inflammatory and antioxidant properties. Vulgarin targets and inhibits HMGB1, NF-κB and iNOS, while regulating key genes involved in hepatic gluconeogenesis; it also blocks inflammatory signaling pathways and inhibits the production and release of pro-inflammatory cytokines such as TNF-α and IL-1β. Vulgarin effectively alleviates pancreatic oxidative stress by reducing lipid peroxidation levels and restoring antioxidant enzyme activity. Vulgarin reverses abnormally elevated serum pancreatic enzyme levels, preserves the integrity of pancreatic acinar cells, and reduces pancreatic edema, hemorrhage and inflammatory infiltration. Vulgarin remodels the function of pancreatic endocrine cells, restores insulin content in β cells, and downregulates glucagon levels in α cells and somatostatin levels in δ cells. Vulgarin can be used in studies related to pancreatic injury and diabetes.
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(2S)-5,7,3',5'-Tetrahydroxyflavanone
0 ImagesCat. No.: HY-N7163CAS No.: 160436-10-2Synonyms: (2S)-3',5,5'7-Tetrahydroxyflavanone
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Aspulvinone H
0 ImagesCat. No.: HY-N14093CAS No.: 57744-69-1Aspulvinone H is an orally active inhibitor of AChE, pancreatic lipase, glutamic-oxaloacetic transaminase 1, and α-glucosidase, with IC50 values of 25.95 μM, 47.06 μM, 5.91/6.91 μM, and 4.6 μM, respectively. It has a Ka of 2.14 μM against GOT1 and a Ki of 6.58 μM against α-glucosidase. Aspulvinone H inhibits cancer cell proliferation, interferes with glutamine metabolism, elevates ROS levels, and induces cell apoptosis and S-phase arrest. Aspulvinone H exhibits antibacterial activity against Staphylococcus aureus. Aspulvinone H inhibits the growth of pancreatic ductal adenocarcinoma xenografts. Aspulvinone H reduces postprandial blood glucose in mice. Aspulvinone H can be used in research related to pancreatic ductal adenocarcinoma, diabetes, and Staphylococcus aureus infection.
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Lipase Substrate
0 ImagesSynonyms: DGGR; 1,2-o-Dilauryl-rac-glycero-3-glutaric acid (6′-methylresorufin) ester
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4'-O-Methylcatechin
0 ImagesCat. No.: HY-W740798CAS No.: 69912-75-04'-O-Methylcatechin acts as a lipase and acetylcholinesterase inhibitor, with an IC50 of 149.93 μM against lipase and an IC50 of 230.89 μM against electric eel-derived acetylcholinesterase. 4'-O-Methylcatechin possesses free radical scavenging activity and can be used in studies on antioxidation, antilipase activity and dementia.
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Glucovanillin (Standard)
0 ImagesGlucovanillin, found in vanilla, is a potential lipase inhibitor. Glucovanillin can be converted into vanillin through an enzyme-coupled process involving cell wall degradation and glucovanillin hydrolysis.
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Ligupurpuroside A
0 ImagesCat. No.: HY-N2087CAS No.: 147396-01-8Ligupurpuroside A is an active product that can be extracted from Ligustrum robustum. Ligupurpuroside A acts as a natural inhibitor of lipase in a competitive manner.
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Panclicin A
0 ImagesCat. No.: HY-N14641CAS No.: 160669-37-4Panclicin A is a potent pancreatic lipase inhibitor.
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Panclicin C
0 ImagesCat. No.: HY-N14643CAS No.: 160669-43-2Panclicin C is a potent pancreatic lipase inhibitor.
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Escin IB (Standard)
0 ImagesCat. No.: HY-N0555RCAS No.: 26339-90-2Escin IB (Standard) is the analytical standard of Escin IB. This product is intended for research and analytical applications. Escin IB is a saponin isolated from skin and the endosperm of seeds of horse chestnut (Aesculus hippocastanum). Escin IB shows inhibitory effect on pancreatic lipase activity.
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Panclicin E
0 ImagesCat. No.: HY-N14647CAS No.: 160669-45-4Panclicin E is a potent pancreatic lipase inhibitor.
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hPL-IN-1
0 ImagesCat. No.: HY-155836CAS No.: 2387374-26-5hPL-IN-1 (compound 2t) is a reversible inhibitor of pancreatic lipase (PL) (IC50=1.86 μM) for anti-obesity research.
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Tridocosahexaenoin
0 ImagesCat. No.: HY-N7862CAS No.: 11094-59-0Tridocosahexaenoin is a homogeneous triglyceride that binds to the gastric lipase of the Pacific walrus (PWGL).
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BAY 59-9435 (Standard)
0 ImagesCat. No.: HY-102056RCAS No.: 654059-21-9BAY 59-9435 (Standard) is the analytical standard of BAY 59-9435 (HY-102056). This product is intended for research and analytical applications. BAY 59-9435 is a potent and selective inhibitor of Hormone Sensitive Lipase (HSL), with an IC50 of 0.023 μM.
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Panclicin D
0 ImagesCat. No.: HY-N14646CAS No.: 160669-44-3Panclicin D is a potent pancreatic lipase inhibitor.
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1,3-Dioleoyl-2-myristoyl glycerol
0 ImagesCat. No.: HY-N7859CAS No.: 158298-95-4Synonyms: 1,3-Dioleoyl-2-myristoyl-rac-glycerol1,3-Dioleoyl-2-myristoyl glycerol is a triacylglycerol that contains oleic acid at the sn-1 and sn-3 positions and myristic acid at the sn-2 position.
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Gluconapin
0 ImagesCat. No.: HY-N10346ACAS No.: 19041-09-9Synonyms: 3-Butenyl glucosinolateGluconapin (3-Butenyl glucosinolate) is an orally active aliphatic glucosinolate and also a flavor modifier. Gluconapin inhibits the elevation of plasma triglyceride levels in mice. Gluconapin also exhibits certain antibacterial activity.
