Phosphatase
Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.
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Phosphatase Inhibitors
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Phosphatase Agonists
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Phosphatase Antagonists
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Phosphatase Activators
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Phosphatase Modulators
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Phosphatase Chemical
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Phosphatase Inducers
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Phosphatase Degraders
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Phosphatase Controls
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Phosphatase Substrates
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Phosphatase Ligands
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Phosphatase Proteins
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Phosphatase Related Products (709)
Related Products (709)
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Recombinant Proteins (66)
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Antibodies (40)
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Related Compound Screening Libraries (1)
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Tristin
0 ImagesTristin is a PTP1B inhibitor (IC50=21.2 μM) with antioxidant and antifungal activities. Tristin inhibits lipid peroxidation and NO production in LPS-stimulated macrophages, and also exhibits activity against a variety of phytopathogenic fungi. Tristin is also able to inhibit cancer cell proliferation. Tristin can be used in the research of diseases associated with phytopathogenic fungal infection, leukemia, type 2 diabetes and inflammatory responses.
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4-(Bromoacetyl)phenoxyacetic acid
0 ImagesCat. No.: HY-112139CAS No.: 29936-81-04-(Bromoacetyl)phenoxyacetic acid (PTP inhibitor III) is a protein tyrosine phosphatase (PTP) inhibitor.
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(E/Z)-Icerguastat hydrochloride
0 ImagesCat. No.: HY-18956ACAS No.: 32597-86-7Synonyms: (E/Z)-Sephin1 hydrochloride; (E/Z)-IFB-088 hydrochloride(E/Z)-Icerguastat hydrochloride ((E/Z)-Sephin1 hydrochloride) is a selective inhibitor with activity that prolongs the phosphorylation effects of eIF2α. (E/Z)-Icerguastat hydrochloride protects cells from defects in proteostasis. (E/Z)-Icerguastat hydrochloride was shown to significantly extend the survival of infected prion mice in a mouse model. (E/Z)-Icerguastat hydrochloride effectively reduces PrPSc expression and prion sequence activity in various neuronal cell lines persistently infected with different prion strains.
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Kanjone
0 ImagesKanjone is a compound found in Millettia peguensis and can be used for the synthesis of protein tyrosine phosphatase 1B (PTP1B) inhibitors. Kanjone holds promise for research in the fields of diabetes and neurological disorders.
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Icerguastat (Standard)
0 ImagesCat. No.: HY-111022RCAS No.: 951441-04-6Synonyms: Sephin1 (Standard); IFB-088 (Standard)Icerguastat (Standard) is the analytical standard of Icerguastat (HY-111022). This product is intended for research and analytical applications. Icerguastat (Sephin1), a derivative of Guanabenz lacKing the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect.
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KLH45 (Standard)
0 ImagesCat. No.: HY-103060RCAS No.: 1632236-44-2
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AtSAL1-IN-1
0 ImagesCat. No.: HY-179596CAS No.: 1060419-15-9AtSAL1-IN-1 (compound V20) is a competitive inhibitor of AtSAL1. AtSAL1-IN-1 elevates the levels of 3’-phosphoadenosine 5’-phosphate (PAP), activates stress-responsive genes and improves oxidative stress tolerance in Arabidopsis. AtSAL1-IN-1 can be used for study of chloroplast-mediated cellular signaling pathways.
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Aloe-emodin-8-O-β-D-glucopyranoside (Standard)
0 ImagesCat. No.: HY-N2451RCAS No.: 33037-46-6Aloe-emodin-8-O-β-D-glucopyranoside (Standard) is the analytical standard of Aloe-emodin-8-O-β-D-glucopyranoside. This product is intended for research and analytical applications. Aloe-emodin-8-O-β-D-glucopyranoside, a compound isolated from Saussrurea lappa, is a moderate inhibitor of human protein tyrosine phosphatase 1B (hPTP1B) with an IC50 of 26.6 μM.
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PTP1B-IN-15 (Standard)
0 ImagesCat. No.: HY-108196RCAS No.: 765317-71-3PTP1B-IN-15 (Standard) is the analytical standard of PTP1B-IN-15 (HY-108196). This product is intended for research and analytical applications. PTP1B-IN-15 is a potent and selective inhibitor of protein tyrosine phosphatase 1B (PTP1B). PTP1B-IN-15 has the potential for the research of type II diabetes and obesity.
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Trimegestone-13C,d3
0 ImagesCat. No.: HY-106827S1Synonyms: RU 27987-13C,d3Trimegestone-13C,d3 is 13C and deuterated labeled Trimegestone (HY-106827). Trimegestone (RU 27987) is an orally active 19-norpregnane progestin. Trimegestone binds to progesterone receptor (PR) with an IC50 value of 3.3 nM (rat PR). Trimegestone increases alkaline phosphatase activity (EC50=0.1 nM) but not luciferase activity. Trimegestone also shows a weak antiandrogenic activity (weak androgen receptor affinity). Trimegestone can be used in studies of contraception or menopausal syndromes.
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Phosphatase-IN-2
0 ImagesCat. No.: HY-180456CAS No.: 2361524-76-5Phosphatase-IN-2 (Compound 26) is a CpxA phosphatase inhibitor. Phosphatase-IN-2 can be used in the research of Escherichia coli infection.
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F1063-0967 (Standard)
0 ImagesCat. No.: HY-101510RCAS No.: 613225-56-2F1063-0967 (Standard) is the analytical standard of F1063-0967 (HY-101510). This product is intended for research and analytical applications. F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM.
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(2-Sulfanylethyl)phosphonic acid
0 ImagesCat. No.: HY-184840CAS No.: 43064-23-9(2-Sulfanylethyl)phosphonic acid (compound 2) is a thiol-containing alkylphosphonic acid inhibitor of purple acid phosphatase (PAP), which inhibits PAP derived from red kidney beans with an IC50 of 3000 μM. The phosphonic acid group of (2-Sulfanylethyl)phosphonic acid acts as a non-hydrolyzable phosphate substrate mimic, and the terminal thiol is designed to enhance interactions with the dinuclear metal active center of PAP. (2-Sulfanylethyl)phosphonic acid can be used in studies related to PAP inhibitors and the structure-activity relationships of dinuclear metal phosphatase inhibition.
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AZ-PFKFB3-67 (Standard)
0 ImagesCat. No.: HY-101972RCAS No.: 1704741-11-6AZ-PFKFB3-67 (Standard) is the analytical standard of AZ-PFKFB3-67 (HY-101972). This product is intended for research and analytical applications. AZ-PFKFB3-67 is a potent and selective PFKFB3 kinase inhibitor with IC50s of 11, 159 and 1130 nM for PFKFB3, PFKFB2 and PFKFB1, respectively. AZ-PFKFB3-67 reduces MCL-1. AZ-PFKFB3-67 has neuroprotective activity.
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Xanthosine-5'-triphosphate lithium
0 ImagesCat. No.: HY-115736BCAS No.: 3056945-74-2Synonyms: 5'-XTP lithiumXanthosine-5'-Triphosphate (5'-XTP) lithium, a nucleotide, is produced by deamination of purine bases. Xanthosine-5'-Triphosphate lithium is a substrate of inosine triphosphate pyrophosphatase (ITPase).
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Hydrocortisone phosphate sodium (Standard)
0 ImagesSynonyms: Hydrocortisone 21-phosphate sodium (Standard); Cortisol 21-phosphate sodium (Standard)Hydrocortisone phosphate sodium (Standard) is the analytical standard of Hydrocortisone phosphate sodium (HY-105656). This product is intended for research and analytical applications. Hydrocortisone phosphate sodium is a soft steroid with low anti-inflammatory properties and a short duration of action. Hydrocortisone phosphate sodium can be used for the research for several ocular conditions and gastric ulcers.
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NSC 95397 (Standard)
0 ImagesCat. No.: HY-108543RCAS No.: 93718-83-3NSC 95397 (Standard) is the analytical standard of NSC 95397 (HY-108543). This product is intended for research and analytical applications. NSC 95397 is a potent, selective Cdc25 dual specificity phosphatase inhibitor (Ki=32 nM (Cdc25A), 96 nM (Cdc25B), 40 nM (Cdc25C); IC50=22.3 nM (human Cdc25A), 56.9 nM (human Cdc25C), 125 nM (Cdc25B)). NSC 95397 inhibits mitogen-activated protein Kinase phosphatase-1 (MKP-1) and suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway.
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PDM11
0 ImagesPDM11 is a derivative of antioxidant resveratrol. PDM11 do not exhibit any significant protective effect against oxidation of linoleate micelles initiated by radiolysis-generated hydroxyl radicals. PDM11 is inactive in resveratrol activity assays.
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Dehydrodanshenol A
0 ImagesCat. No.: HY-N12736CAS No.: 1444618-61-4Dehydrodanshenol A is a non-competitive inhibitor of Protein tyrosine phosphatase 1B (PTP1B), with an IC50 value of 8.5 μM. Dehydrodanshenol A can be used in diabetes-related research.
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NAZ2329 (Standard)
0 ImagesNAZ2329 (Standard) is the analytical standard of NAZ2329 (HY-103693). This product is intended for research and analytical applications. NAZ2329, the first cell-permeable inhibitor of R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs), allosterically and preferentially inhibits PTPRZ (IC50=7.5 µM for hPTPRZ1) and PTPRG (IC50=4.8 µM for hPTPRG) over other PTPs. NAZ2329 binds to the active D1 domain and more potently inhibits PTPRZ-D1 fragment (IC50 of 1.1 µM) than the whole intracellular (D1 + D2) fragment (IC50 of 7.5 µM). NAZ2329 can effectively inhibit tumor growth of the glioblastoma cells and suppress stem cell-like properties.
