Thrombin
Thrombin is a Na+-activated, serine protease which is activated by the enzymatic cleavage of two sites on prothrombin by activated Factor X. Thrombin exists in two allosteric forms, slow (S) and fast (F), target toward anticoagulant and procoagulant activities.
Thrombin is the main effector protease in primary hemostasis by activating platelets and plays a key role in secondary hemostasis. Besides its well-known functions in hemostasis, thrombin also plays a role in various non-hemostatic biological and pathophysiologic processes, predominantly mediated through activation of protease-activated receptors (PARs). PAR-1, PAR-3, and PAR-4 are cleaved by thrombin, whereas PAR-2 is cleaved by trypsin. Thrombin also plays a crucial role in the migration and metastasis of human cancer cells.
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Thrombin Related Products (236)
Related Products (236)
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Antibodies (9)
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Idrabiotaparinux
0 ImagesCat. No.: HY-19442CAS No.: 774531-07-6Idrabiotaparinux, a derivative of Idraparinux (HY-19691), is a novel synthetic anticoagulant that links Idraparinux, a specific, indirect factor Xa inhibitor, to biotin.
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H-D-CHA-Ala-Arg-pNA
0 ImagesCat. No.: HY-P6027CAS No.: 143556-06-3H-D-CHA-Ala-Arg-pNA is a chromogenic substrate for the amidolytic assay.
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Thrombin inhibitor 6
0 ImagesCat. No.: HY-151983CAS No.: 1628224-94-1Thrombin inhibitor 6 is a potent thrombin inhibitor (IC50: 1 nM). Thrombin inhibitor 6 has the function as an anticoagulant.
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1,2-Di-(9Z-hexadecenoyl)-sn-glycerol
0 ImagesCat. No.: HY-N16369CAS No.: 127994-00-71,2-Di-(9Z-hexadecenoyl)-sn-glycerol (Compound 2e) is a diacylglycerol derivative that can be isolated from the fungus Stereum Hirsutum. 1,2-Di-(9Z-hexadecenoyl)-sn-glycerol has potential thrombin-inhibiting activity and can be used in research related to antithrombotic drugs.
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SSR182289
0 ImagesCat. No.: HY-19674CAS No.: 363151-21-7Synonyms: SSR182289A free baseSSR182289 (SSR182289A free base) is a selective and potent orally active thrombin inhibitor. SSR182289 competitively and selectivity inhibits human thrombin (Ki=0.031 μM). SSR182289 demonstrates anticoagulant activity in vitro (thrombin time EC100=96 nM) and inhibits tissue factor-induced thrombin generation (IC50=0.15 μM) in human plasma. SSR182289 inhibits thrombin-induced aggregation of human platelets (IC50=32 nM), but has no effect on aggregation induced by other platelet agonists .
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DPC423 free base
0 ImagesCat. No.: HY-11090CAS No.: 209957-47-1DPC423 free base is a selective and orally active factor Xa inhibitor with a Kis of 0.15 (human) and 0.3 (rabbit) nM. DPC423 free base exhibits Kis of 60, 61 and 6000 nM against human trypsin, plasma kallikrein and thrombin. DPC423 free base blocks the formation of prothrombinase complex, reduces thrombin production, inhibits fibrin formation and platelet activation. DPC423 free base can be used for the study of anticoagulation of arterial thrombosis.
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Napsagatran
0 ImagesCat. No.: HY-15759CAS No.: 154397-77-0Synonyms: Ro 46-6240; Ro 46-6240/010Napsagatran (Ro 46-6240) is a potent thrombin inhibitor. Napsagatran exhibits anticoagulant effects in vitro and in vivo. Napsagatran can be used in antithrombotic research[1][2].
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Rovunaptabin sodium
0 ImagesCat. No.: HY-148826APurity: 98.96%Synonyms: ARC 183 sodium; BC 007 sodiumRovunaptabin sodium (ARC 183 sodium) is a DNA aptamer, which is a single-stranded DNA molecule consisting of 15 deoxynucleotides that forms well-defined three-dimensional configuration, allowing it to bind to thrombin with high affinity and specificity.
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Efegatran sulfate
0 ImagesCat. No.: HY-114603ACAS No.: 126721-07-1Synonyms: LY 294468 sulfateEfegatran (LY 294468) sulfate is an inhibitor for thrombin, which inhibits aggregation of platelets, and exhibits anticoagulant and antithrombotic activities.
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(1R,3S)-THCCA-Asn
0 ImagesCat. No.: HY-151146CAS No.: 1349084-71-4(1R,3S)-THCCA-Asn (4j) is a selective thrombin inhibitor with the IC50 value in the range of 0.07 to 0.14 μM. ((1R,3S)-THCCA-Asn has antithrombotic activity.
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Antiplatelet agent 3
0 ImagesCat. No.: HY-173207CAS No.: 1623073-71-1Antiplatelet agent 3 (Compound K-10) is a compound with anti-platelet aggregation activity. The IC50 values for platelet aggregation induced by ADP, AA and COL are 2.55, 3.22 and 2.09 mg/mL, respectively. Antiplatelet agent 3 is expected to be used in the research of cardiovascular diseases.
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BMS 180742
0 ImagesCat. No.: HY-P2021CAS No.: 138828-04-3BMS 180742 is a thrombin exosite inhibitor. BMS 180742 does not inhibit arterial thrombosis.
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Ciraparantag-d8 tetrahydrochloride diacetate
0 ImagesCat. No.: HY-18660SSynonyms: PER977-d8 tetrahydrochloride diacetateCiraparantag-d8 (PER977-d8) tetrahydrochloride diacetate is the deuterium labeled Ciraparantag (HY-18660). Ciraparantag is a thrombin and factor Xa inhibitor. Ciraparantag is a broad-spectrum reversal agent for anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants. It is reported to antagonize the effects of all coagulants except VKAs and agratroban.
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d-Phe-Pro-Arg-PABA-Resorufin
0 ImagesCat. No.: HY-139814CAS No.: 1979130-73-8d-Phe-Pro-Arg-PABA-Resorufin is a selective Thrombin substrate. d-Phe-Pro-Arg-PABA-Resorufin can be cleaved by thrombin to release fluorescent and chromogenic products. d-Phe-Pro-Arg-PABA-Resorufin enables sensitive detection of the thrombin inhibitor Dabigatran (HY-10163) via thrombin-mediated cleavage attenuation.
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Ono 3307 free base
0 ImagesCat. No.: HY-167924CAS No.: 76472-28-1Ono 3307 Free base is a novel synthetic protease inhibitor that exhibits protective effects against acute pancreatitis by preventing hyperamylasemia and pancreatic edema. Ono 3307 Free base also inhibits the redistribution of lysosomal enzymes in acinar cells and mitigates lactic dehydrogenase discharge. Ono 3307 Free base effectively reduces cathepsin B leakage from lysosomes in a dose-dependent manner. Ono 3307 Free base is able to target trypsin (Ki=48 nM), thrombin (Ki=0.18 μM), plasma kallikrein (Ki=0.29 μM), plasmin (Ki=0.31 μM), pancreatic kallikrein (Ki=3.6 μM), and chymotrypsin (Ki=47 μM).
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SA-152
0 ImagesCat. No.: HY-123120CAS No.: 142450-99-5SA-152 is an organophosphorus inhibitor. SA-152 modulates the fibrinogen coagulation and TAME esterase activity of bovine α-thrombin.
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Melagatran-d11
0 ImagesCat. No.: HY-W743984Melagatran-d11 is the deuterium labeled Melagatran (HY-129056). Melagatran is a direct and orally active inhibitor of thrombin, without interacting with any other enzymes in the coagulation cascade or fibrinolytic enzymes aside from thrombin. Melagatran does not require endogenous co-factors for its antithrombin effect and may help to alleviate some of the damaging effects of endotoxemia. Melagatran has the potential to provide a rational approach in the prevention of arterial occlusion.
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Hirudin (54-65) TFA
0 ImagesCat. No.: HY-P1636AHirudin (54-65) TFA is a fragment of Hirudin with anticoagulant effects. Hirudin is a thrombin inhibitor with blood anticoagulant property.
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AT-1459
0 ImagesCat. No.: HY-119680CAS No.: 294658-50-7AT-1459 is a selective and orally active direct Thrombin inhibitor with a Ki value of 4.9 nM. AT-1459 exhibits excellent antithrombotic activity in both rat models of venous and arterial thrombosis. AT-1459 can be used for research on thrombosis-related diseases.
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BCH-2763
0 ImagesCat. No.: HY-P2102CAS No.: 204641-27-0
