Thrombin

Related Products

Thrombin is a Na⁺-activated, serine protease which is activated by the enzymatic cleavage of two sites on prothrombin by activated Factor X. Thrombin exists in two allosteric forms, slow (S) and fast (F), target toward anticoagulant and procoagulant activities.

Thrombin is the main effector protease in primary hemostasis by activating platelets and plays a key role in secondary hemostasis. Besides its well-known functions in hemostasis, thrombin also plays a role in various non-hemostatic biological and pathophysiologic processes, predominantly mediated through activation of protease-activated receptors (PARs). PAR-1, PAR-3, and PAR-4 are cleaved by thrombin, whereas PAR-2 is cleaved by trypsin. Thrombin also plays a crucial role in the migration and metastasis of human cancer cells.

Thrombin Related Products (222)
Antibodies (9)

By Effects:	Inhibitors (159) Agonists (2) Substrates (7) Ligands (2) Antagonists (4) Activators (10)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-18660S

Ciraparantag-d₈ tetrahydrochloride diacetate	Inhibitor
Ciraparantag-d₈ (PER977-d₈) tetrahydrochloride diacetate is the deuterium labeled Ciraparantag (HY-18660). Ciraparantag is a thrombin and factor Xa inhibitor. Ciraparantag is a broad-spectrum reversal agent for anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants. It is reported to antagonize the effects of all coagulants except VKAs and agratroban.

HY-139814

d-Phe-Pro-Arg-PABA-Resorufin	Substrate
d-Phe-Pro-Arg-PABA-Resorufin is a selective Thrombin substrate. d-Phe-Pro-Arg-PABA-Resorufin can be cleaved by thrombin to release fluorescent and chromogenic products. d-Phe-Pro-Arg-PABA-Resorufin enables sensitive detection of the thrombin inhibitor Dabigatran (HY-10163) via thrombin-mediated cleavage attenuation.

HY-167924

Ono 3307 free base
Ono 3307 Free base is a novel synthetic protease inhibitor that exhibits protective effects against acute pancreatitis by preventing hyperamylasemia and pancreatic edema. Ono 3307 Free base also inhibits the redistribution of lysosomal enzymes in acinar cells and mitigates lactic dehydrogenase discharge. Ono 3307 Free base effectively reduces cathepsin B leakage from lysosomes in a dose-dependent manner. Ono 3307 Free base is able to target trypsin (K_i=48 nM), thrombin (K_i=0.18 μM), plasma kallikrein (K_i=0.29 μM), plasmin (K_i=0.31 μM), pancreatic kallikrein (K_i=3.6 μM), and chymotrypsin (K_i=47 μM).

HY-123120

SA-152
SA-152 is an organophosphorus inhibitor. SA-152 modulates the fibrinogen coagulation and TAME esterase activity of bovine α-thrombin.

HY-W743984

Melagatran-d₁₁
Melagatran-d₁₁ is the deuterium labeled Melagatran (HY-129056). Melagatran is a direct and orally active inhibitor of thrombin, without interacting with any other enzymes in the coagulation cascade or fibrinolytic enzymes aside from thrombin. Melagatran does not require endogenous co-factors for its antithrombin effect and may help to alleviate some of the damaging effects of endotoxemia. Melagatran has the potential to provide a rational approach in the prevention of arterial occlusion.

HY-P1636A

Hirudin (54-65) TFA	Inhibitor
Hirudin (54-65) TFA is a fragment of Hirudin with anticoagulant effects. Hirudin is a thrombin inhibitor with blood anticoagulant property.

HY-119680

AT-1459	Inhibitor
AT-1459 is a selective and orally active direct Thrombin inhibitor with a K_i value of 4.9 nM. AT-1459 exhibits excellent antithrombotic activity in both rat models of venous and arterial thrombosis. AT-1459 can be used for research on thrombosis-related diseases.

HY-P2102

BCH-2763	Inhibitor
BCH-2763 is a potent and selective Thrombin inhibitor. BCH-2763 has a very high affinity for thrombin (K_i = 0.11 nM). BCH-2763 can effectively inhibit fibrin formation, platelet aggregation, and free thrombin activity. BCH-2763 can be used for the study of thrombosis.

HY-160824

Neutrophil elastase-IN-7	Inhibitor
Neutrophil elastase-IN-7 (Compound 12) is an effective inhibitor of neutrophil elastase (HNE), with an IC₅₀ value of 0.54 μM. Neutrophil elastase-IN-7 also exhibits significant inhibitory activity against various coagulation proteins, with the IC₅₀ values for thrombin, FXa, FXIa, and FXIIIa being 8.2, 12.7, 1.2, and 5.7 μM, respectively. Neutrophil elastase-IN-7 can be used for research on inflammation, innate immune responses, and tissue remodeling.

HY-N17623

Ainsliaeasin C	Inhibitor
Ainsliaeasin C, a 7-hydroxycoumarin derivative, is an orally active anticoagulant agent that can be found in Ainsliaea fragrans. Ainsliaeasin C exerts anticoagulant activity both in vitro and in vivo. Ainsliaeasin C can be used for the research on thrombotic disorders.

HY-114603B

Efegatran dihydrochloride	Inhibitor
Efegatran (LY 294468) dihydrochloride is an inhibitor for thrombin, which inhibits aggregation of platelets, and exhibits anticoagulant and antithrombotic activities.

HY-10163S5

Dabigatran-d₇
Dabigatran-d₇ (BIBR 953-d₇; BIBR 953ZW-d₇) is the deuterium labeled Dabigatran (HY-10163). Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC₅₀=10 nM).

HY-P5371

TFLLRNPNDK-NH2	Activator
TFLLRNPNDK-NH2 is a biological active peptide. (This peptide is a thrombin receptor activating peptide. This PAR-1 agonist peptide reversibly binds to PAR-1 mimicking the 'tethered ligand' that thrombin makes available through proteolytic cleavage of substrate. It is also known to cause increase in liquid and protein permeability much like thrombin.)

HY-12586

AZD6564	Inhibitor
AZD6564 is an orally active inhibitor for fibrinolysis through disruption of plasma kinase-fibrin interaction. AZD6564 dissolves human plasma clot with an IC₅₀ of 0.44 μM. AZD6564 ameliorates hemorrhage in rats with EC₅₀ of 1.62 μM, and exhibits good pharmacokinetic characteristics in rats.

HY-P4593

Z-Gly-Pro-Arg-4MβNA
Z-Gly-Pro-Arg-4MβNA is the cleavage of the substrate of thrombin to release free 4-methoxy-2-naphthylamine (4MβNA). Free 4MβNA can be captured by 5-nitrosalicylaldehyde to produce an insoluble yellow fluorescent and marks the site of thrombin activity.

HY-10163S3

Dabigatran-¹³C,d₃	Inhibitor
Dabigatran-¹³C,d₃ is the ¹³C- and deuterium labeled Dabigatran. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC₅₀=10 nM).

HY-P5027

Cbz-Lys-Arg-pNA	Substrate
Cbz-Lys-Arg-pNA is a peptide substrate containing pNA as the chromogenic group. Cbz-Lys-Arg-pNA is widely used in enzymatic analysis, including thrombin, plasmin, factor Xa and Kallikrein.

HY-178398S

Nonadecanoic acid-d₃
Nonadecanoic acid-d₃ is the deuterium labeled Nonadecanoic acid (HY-W004261). Nonadecanoic acid is a 19-carbon long saturated fatty acid. Nonadecanoic acid is the major constituent of the substance secreted by Rhinotermes marginalis. Nonadecanoic acid can be isolated from several sources, including fungus, plant, and marine sponge. Nonadecanoic acid exhibits inhibitory effects on fibrinolysis and plasmin activity. Nonadecanoic acid produced from Streptomyces is an anti-tumor agent and inhibits IL-12 production.

HY-120563

LY135305	Inhibitor
LY 135305 is a thrombin activation inhibitor. LY 135305 inhibits spontaneous metastasis and increases animal survival.

HY-19373

RWJ-445167	Inhibitor
RWJ-445167 (3DP-10017) is a dual inhibitor of thrombin and factor Xa with K_i of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity.

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Thrombin

Thrombin

Thrombin Related Products (222)

Antibodies (9)

Thrombin Related Products (222):