1979130-73-8
Chemical Structure
d-Phe-Pro-Arg-PABA-Resorufin
- CAS No.: 1979130-73-8
- Formula:C39H42N8O6
- Molecular Weight:718.82
IUPAC Name: (S)-1-(D-phenylalanyl)-N-((S)-5-guanidino-1-oxo-1-((4-(((3-oxo-3H-phenoxazin-7-yl)oxy)methyl)phenyl)amino)pentan-2-yl)pyrrolidine-2-carboxamide
InChIKey: LWNGALSXPKCECV-CDSZWMAJSA-N
SMILES: O(CC1=CC=C(NC([C@@H](NC(=O)[C@H]2N(C([C@@H](CC3=CC=CC=C3)N)=O)CCC2)CCCNC(=N)N)=O)C=C1)C=4C=C5C(N=C6C(O5)=CC(=O)C=C6)=CC4
Biological Activity: d-Phe-Pro-Arg-PABA-Resorufin is a selective Thrombin substrate. d-Phe-Pro-Arg-PABA-Resorufin can be cleaved by thrombin to release fluorescent and chromogenic products. d-Phe-Pro-Arg-PABA-Resorufin enables sensitive detection of the thrombin inhibitor Dabigatran (HY-10163) via thrombin-mediated cleavage attenuation[1][2].
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d-Phe-Pro-Arg-PABA-Resorufin | d-Phe-Pro-Arg-PABA-Resorufin is a selective Thrombin substrate. d-Phe-Pro-Arg-PABA-Resorufin can be cleaved by thrombin to release fluorescent and chromogenic products. d-Phe-Pro-Arg-PABA-Resorufin enables sensitive detection of the thrombin inhibitor Dabigatran (HY-10163) via thrombin-mediated cleavage attenuation. | |||||||||||||||||||||
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References
- [1]. Arian D, et al. A Chromogenic and Fluorogenic Peptide Substrate for the Highly Sensitive Detection of Proteases in Biological Matrices. J Med Chem. 2016;59(16):7576-7583. [Content Brief]
- [2]. Díez-Buitrago B, et al. Biosensing strategies based on enzymatic reactions and nanoparticles. Analyst. 2018;143(8):1727-1734. [Content Brief]
