Thrombin
Thrombin is a Na+-activated, serine protease which is activated by the enzymatic cleavage of two sites on prothrombin by activated Factor X. Thrombin exists in two allosteric forms, slow (S) and fast (F), target toward anticoagulant and procoagulant activities.
Thrombin is the main effector protease in primary hemostasis by activating platelets and plays a key role in secondary hemostasis. Besides its well-known functions in hemostasis, thrombin also plays a role in various non-hemostatic biological and pathophysiologic processes, predominantly mediated through activation of protease-activated receptors (PARs). PAR-1, PAR-3, and PAR-4 are cleaved by thrombin, whereas PAR-2 is cleaved by trypsin. Thrombin also plays a crucial role in the migration and metastasis of human cancer cells.
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Thrombin Related Products (236)
Related Products (236)
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Antibodies (9)
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DuP 714
0 ImagesCat. No.: HY-117561CAS No.: 130982-43-3DuP 714 is an oral active thrombin inhibitor with the IC50 values of 150 nM aganist thrombin-induced aggregation in washed human platelets. DuP 714 can be used for study of arterial thrombosi.
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DS-1040 Tosylate (Standard)
0 ImagesCat. No.: HY-101918RCAS No.: 1335138-89-0DS-1040 Tosylate (Standard) is the analytical standard of DS-1040 Tosylate (HY-101918). This product is intended for research and analytical applications. DS-1040 Tosylate is an orally active, selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC50s of 5.92 nM and 8.01 nM for human and rat TAFIa. DS-1040 Tosylate is a fibrinolysis enhancer for thromboembolic diseases.
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LY 806303
0 ImagesCat. No.: HY-117798CAS No.: 149725-15-5LY 806303 is a potent and selective inhibitor of human α-thrombin. LY 806303 specifically acylates Ser-205 within the catalytic triad of α-thrombin on the heavy chain and a key site involved in the enzymatic activity of thrombin. The mechanism of action of LY 806303 as an enzyme inhibitor is through the specific acylation of this catalytic serine residue.
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Argatroban monohydrate (Standard)
0 ImagesSynonyms: MD-805 monohydrate (Standard); MCI-9038 monohydrate (Standard)Argatroban (monohydrate) (Standard) is the analytical standard of Argatroban (monohydrate). This product is intended for research and analytical applications. Argatroban (monohydrate) (MD-805 (monohydrate)) is a direct, selective thrombin inhibitor.
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RWJ-671818
0 ImagesCat. No.: HY-164251CAS No.: 252271-49-1RWJ-671818 is an orally active inhibitor of human α-thrombin with a Ki of 1.3 nM. RWJ-671818 can be studied in research on venous and arterial thrombosis.
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PS-915 dihydrochloride
0 ImagesCat. No.: HY-136898CAS No.: 86356-77-6PS-915 dihydrochloride is a peptide substrate used in a colorimetric assay for plasma antithrombin III (ATIII). PS-915 dihydrochloride is highly specific for thrombin. By enzyme hydrolysis, PS-915 dihydrochloride liberates 3-carboxy-4-hydroxyaniline (CHA), which turns blue in color due to the complex formation with added alkaline-pentacyanoammine ferroate.
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Edoxaban tosylate monohydrate (Standard)
0 ImagesCat. No.: HY-10264BRCAS No.: 1229194-11-9Synonyms: DU-176b monohydrate (Standard)Edoxaban tosylate monohydrate (Standard) is the analytical standard of Edoxaban tosylate monohydrate (HY-10264B). This product is intended for research and analytical applications. Edoxaban (DU-176b) monohydrate is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Kis of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban monohydrate exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban monohydrate can be used for preventing thromboembolic disease research.
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Anisindione (Standard)
0 ImagesAnisindione (Standard) is the analytical standard of Anisindione. This product is intended for research and analytical applications. Anisindione is an oral indandione anticoagulant. Anisindione inhibits the formation of active procoagulant factors II, VII, IX and X. Anisindione can be used in anticoagulation-related research.
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AZD 9684
0 ImagesCat. No.: HY-107023CAS No.: 775274-06-1AZD 9684 is a TAFIa inhibitor. AZD 9684 is applicable to research related to thrombosis and pulmonary embolism.
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Dabigatran acyl-β-D-glucuronide
0 ImagesCat. No.: HY-122813CAS No.: 1015167-40-4Dabigatran acyl-β-D-glucuronide is an active metabolite of the thrombin inhibitor Dabigatran (HY-10163). Dabigatran acyl-β-D-glucuronide increases activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma.
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Dabigatran etexilate mesylate (Standard)
0 ImagesSynonyms: BIBR 1048MS (Standard); Dabigatran etexilate methanesulfonate (Standard)Dabigatran etexilate (mesylate) (Standard) is the analytical standard of Dabigatran etexilate (mesylate). This product is intended for research and analytical applications. Dabigatran etexilate mesylate (BIBR 1048MS) is an orally active proagent of Dabigatran (a direct inhibitor of thrombin). Dabigatran etexilate mesylate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation.
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Thrombin Inhibitor 2 (Standard)
0 ImagesCat. No.: HY-10217RCAS No.: 312904-62-4Thrombin Inhibitor 2 (Standard) is the analytical standard of Thrombin Inhibitor 2 (HY-10217). This product is intended for research and analytical applications. Thrombin Inhibitor 2 is a small molecule direct thrombin inhibitor, extracted from US8541580B2. Thrombin Inhibitor 2 has antithrombotic activity.
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BMS-189664 hydrochloride
0 ImagesCat. No.: HY-19219ACAS No.: 185252-36-2BMS-189664 hydrochloride is a potent, selective, and orally active reversible inhibitor of a-thrombin, with an IC50 of 0.046 μM. BMS-189664 hydrochloride can be used for arterial and venous thrombosis research.
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Odiparcil (Standard)
0 ImagesCat. No.: HY-10277RCAS No.: 137215-12-4Synonyms: SB-424323 (Standard)Odiparcil (Standard) is the analytical standard of Odiparcil (HY-10277). This product is intended for research and analytical applications. Odiparcil (SB-424323) is an orally active β-D-xyloside derivative. Odiparcil can effectively divert the synthesis of cellular glycosaminoglycans (GAG) into secreted soluble species and reduce GAG accumulation. Odiparcil shows antithrombin and antiplatelet activity. Odiparcil can be used for the researches of metabolic and cardiovascular disease, such as mucopolysaccharidoses (MPS) and thrombosis.
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Oxopurpureine
0 ImagesCat. No.: HY-N15271CAS No.: 32845-27-5
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BMS-189664
0 ImagesCat. No.: HY-19219CAS No.: 162166-80-5BMS-189664 is a potent, selective, and orally active reversible inhibitor of a-thrombin, with an IC50 of 0.046 μM. BMS-189664 can be used for arterial and venous thrombosis research.
