130982-43-3
130982-43-3
Chemical Structure
DuP 714
- CAS No.: 130982-43-3
- Formula:C21H33BN6O5
- Molecular Weight:460.33
IUPAC Name: ((R)-1-((S)-1-(acetyl-D-phenylalanyl)pyrrolidine-2-carboxamido)-4-guanidinobutyl)boronic acid
InChIKey: FXFYPTZERULUBS-SQNIBIBYSA-N
SMILES: CC(N[C@H](CC1=CC=CC=C1)C(N2[C@@H](CCC2)C(N[C@H](B(O)O)CCCNC(N)=N)=O)=O)=O
Biological Activity: DuP 714 is an oral active thrombin inhibitor with the IC50 values of 150 nM aganist thrombin-induced aggregation in washed human platelets. DuP 714 can be used for study of arterial thrombosi[1][2].
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DuP 714 | DuP 714 is an oral active thrombin inhibitor with the IC50 values of 150 nM aganist thrombin-induced aggregation in washed human platelets. DuP 714 can be used for study of arterial thrombosi. | |||||||||||||||||||||
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References
- [1]. Reilly TM, et al. Effect of thrombin inhibitors on platelet functions: comparative analysis of DuP 714 and hirudin. Blood Coagul Fibrinolysis. 1992;3(5):513-517. [Content Brief]
- [2]. Mitchell TJ, et al. Analysis of the thrombin inhibitor DuP 714 by an enzyme-linked immunosorbent assay. Blood Coagul Fibrinolysis. 1994;5(4):517-521. [Content Brief]
Keywords
