252271-49-1
252271-49-1
Chemical Structure
RWJ-671818
- CAS No.: 252271-49-1
- Formula:C18H23F2N7O3
- Molecular Weight:423.42
InChIKey: IDCKXHIGLKQWMM-UHFFFAOYSA-N
SMILES: O=C(CN1C(C(NCC(F)(C2=CC=CC=C2)F)=NC=C1C)=O)NCCONC(N)=N
Biological Activity: RWJ-671818 is an orally active inhibitor of human α-thrombin with a Ki of 1.3 nM. RWJ-671818 can be studied in research on venous and arterial thrombosis[1].
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RWJ-671818 | RWJ-671818 is an orally active inhibitor of human α-thrombin with a Ki of 1.3 nM. RWJ-671818 can be studied in research on venous and arterial thrombosis. | |||||||||||||||||||||
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References
- [1]. Lu, T., et al., (2010). Discovery and clinical evaluation of 1-{N-[2-(amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a thrombin inhibitor with an oxyguanidine P1 motif. Journal of medicinal chemistry, 53(4), 1843-1856. [Content Brief]
Keywords
