Thrombin
Thrombin is a Na+-activated, serine protease which is activated by the enzymatic cleavage of two sites on prothrombin by activated Factor X. Thrombin exists in two allosteric forms, slow (S) and fast (F), target toward anticoagulant and procoagulant activities.
Thrombin is the main effector protease in primary hemostasis by activating platelets and plays a key role in secondary hemostasis. Besides its well-known functions in hemostasis, thrombin also plays a role in various non-hemostatic biological and pathophysiologic processes, predominantly mediated through activation of protease-activated receptors (PARs). PAR-1, PAR-3, and PAR-4 are cleaved by thrombin, whereas PAR-2 is cleaved by trypsin. Thrombin also plays a crucial role in the migration and metastasis of human cancer cells.
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Thrombin Related Products (236)
Related Products (236)
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Antibodies (9)
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Dabigatran-13C6
0 ImagesCat. No.: HY-10163S2CAS No.: 1210608-88-0Synonyms: BIBR 953-13C6; BIBR 953ZW-13C6Dabigatran-13C6 is the 13C labeled Dabigatran. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM).
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Ciraparantag TFA
0 ImagesCat. No.: HY-18660ACAS No.: 1438492-27-3Synonyms: PER977 TFACiraparantag (PER977) TFA is a thrombin and factor Xa inhibitor. Ciraparantag TFA is a broad-spectrum reversal agent for anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants. It is reported to antagonize the effects of all coagulants except VKAs and agratroban.
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Thrombin inhibitor 13
0 ImagesCat. No.: HY-170485Thrombin inhibitor 13 (Compound 13a) is a covalent and reversible inhibitor for thrombin (FIIa) with an IC50 of 0.7 nM. Thrombin inhibitor 13 prolongs the activated partial thromboplastin time (aPTT) and prothrombin time (PT), exhibits antithrombotic and anticoagulant activities.
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YD-3
0 ImagesCat. No.: HY-111766CAS No.: 170632-41-4YD-3 is a platelet activation inhibitor. YD-3 inhibits Thrombine-induced rabbit platelets aggregation (IC50: 28.3 μM) and phosphoinositol production. In addition, YD-3 also inhibits Trypsin-induced platelet aggregation in human and rabbit with the IC50 of 38.1 μM and 5.7 μM, respectively, but does not affect the proteolytic activity of trypsin.
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Porcine Factor Xa
0 ImagesPorcine Factor Xa is a serine protease that plays a central role in blood coagulation, with prothrombin as its physiological substrate. Porcine Factor Xa catalyzes the conversion of prothrombin to thrombin, activates factor VIII, and hydrolyzes peptide, thioester, and amide substrates. Porcine Factor Xa cleaves protease-activated receptors 1 and 2 to activate intracellular signal transduction. Porcine Factor Xa regulates multiple cellular pathways, mediates various cellular activities, tissue remodeling and cancer cell migration, and inhibits apoptosis in some cancer cells. Porcine Factor Xa protects hippocampal neurons against glutamate-induced damage. Porcine Factor Xa participates in embryonic vascular development and regulates immune hematopoiesis; its activity is inhibited by soybean trypsin inhibitor, and cannot be enhanced by phospholipids. Porcine Factor Xa regulates immune responses and macrophage polarization, and participates in fibrosis, vascular remodeling and tumor progression through non-coagulant effects. Porcine Factor Xa can be used in research related to atherosclerosis, fibrosis, asthma, cancer, thromboinflammation, sepsis, etc.
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L 722151
0 ImagesCat. No.: HY-120491CAS No.: 122841-09-2L 722151 is a competitive inhibitor for factor XIIIa with Ki of 49 µM. L 722151 accelerates tissue plasminogen activator-catalyzed clot dissolution, and exhibits antithrombotic efficacy.
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Pyr-Arg-Thr-Lys-Arg-AMC
0 ImagesCat. No.: HY-P4349CAS No.: 155575-02-3
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Knob A peptide GPRPFPAC
0 ImagesCat. No.: HY-P11209CAS No.: 1261229-38-2Knob A peptide GPRPFPAC is a fibrin knob peptide. PEGylated Knob A peptide GPRPFPAC has enhanced anticoagulant activity.
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NAPAP
0 ImagesCat. No.: HY-174285CAS No.: 137171-40-5
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Anti-Factor V Antibody
0 ImagesCat. No.: HY-P991991
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LK-732
0 ImagesCat. No.: HY-167858CAS No.: 673485-33-1LK-732 is a thrombin inhibitor with anti-thrombotic activity.LK-732 has a dose-dependent inhibition of hypercoagulability in the model, with an IC50 of 1.3 mg/kg. LK-732 can be used in cardiovascular and cerebrovascular research.
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OM-189
0 ImagesCat. No.: HY-100245CAS No.: 55381-18-5OM-189 is a selective synthetic thrombin inhibitor.
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Fitusiran sodium scrambled negative control
0 ImagesCat. No.: HY-132587CFitusiran sodium scrambled negative control is the sequence scrambled negative control of Fitusiran sodium. Fitusiran (ALN-AT3SC) sodium is a siRNA strategy. Fitusiran delivers siRNA targeting the SERPINC1 gene in hepatocytes to inhibit antithrombin synthesis. Fitusiran sodium enhances thrombin activity and increases Thrombin generation, thereby restoring hemostatic function. Fitusiran sodium can be used in hemophilia-related research.
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Acetyl-Hirudin (55-65) sulfated
0 ImagesCat. No.: HY-P4795CAS No.: 125441-01-2Acetyl-Hirudin (55-65) (sulfated) is a Acetyl-fragment of Hirudin. Hirudin is a thrombin inhibitor with blood anticoagulant property.
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Anti-Factor X Antibody
0 ImagesCat. No.: HY-P991992
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FXIIa-IN-1
0 ImagesCat. No.: HY-149396CAS No.: 3052551-19-3XIIa-IN-1-IN-3 (Compound 22) is a Factor XIIa inhibitor (Kiapp: 97.8 nM). XIIa-IN-1-IN-3 can be used for research of thrombosis.
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Heparin calcium (MW 15000-19000)
0 ImagesCat. No.: HY-107966CAS No.: 37270-89-6Synonyms: Nadroparin calcium (MW 15000-19000)Heparin calcium (MW 15000-19000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin.
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Ximelagatran (Standard)
0 ImagesSynonyms: H 376/95 (Standard)Ximelagatran (Standard) is the analytical standard of Ximelagatran (HY-10787). This product is intended for research and analytical applications. Ximelagatran (H 376/95) is an orally active thrombin inhibitor that selectively and competitively inhibits both free and clot-bound thrombin. Ximelagatran is an anticoagulant agent with a rapid onset of anticoagulant effect, predictable, dose-dependent pharmcoKinetics and pharmacodynamics.
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Dabigatran (ethyl ester hydrochloride) (Standard)
0 ImagesDabigatran ethyl ester hydrochloride (Standard) is the analytical standard of Dabigatran ethyl ester hydrochloride (HY-77521). This product is intended for research and analytical applications. Dabigatran ethyl ester hydrochloride is a potent inhibitor of ribosyldihydronicotinamide dehydrogenase (NQO2) with an IC50 value of 0.8 μM and a thrombin inhibitor.
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Bacithrocin D
0 ImagesCat. No.: HY-N13960CAS No.: 96440-64-1Synonyms: Thiolstatin D
