Thrombin

Related Products

Thrombin is a Na⁺-activated, serine protease which is activated by the enzymatic cleavage of two sites on prothrombin by activated Factor X. Thrombin exists in two allosteric forms, slow (S) and fast (F), target toward anticoagulant and procoagulant activities.

Thrombin is the main effector protease in primary hemostasis by activating platelets and plays a key role in secondary hemostasis. Besides its well-known functions in hemostasis, thrombin also plays a role in various non-hemostatic biological and pathophysiologic processes, predominantly mediated through activation of protease-activated receptors (PARs). PAR-1, PAR-3, and PAR-4 are cleaved by thrombin, whereas PAR-2 is cleaved by trypsin. Thrombin also plays a crucial role in the migration and metastasis of human cancer cells.

Thrombin Related Products (222)
Antibodies (9)

By Effects:	Inhibitors (159) Agonists (2) Substrates (7) Ligands (2) Antagonists (4) Activators (10)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P991992

Anti-Factor X Antibody	Inhibitor
Anti-Factor X Antibody is an anti-Factor X antibody. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977).

HY-149396

FXIIa-IN-1	Inhibitor
XIIa-IN-1-IN-3 (Compound 22) is a Factor XIIa inhibitor (K_i^app: 97.8 nM). XIIa-IN-1-IN-3 can be used for research of thrombosis.

HY-107966

Heparin calcium (MW 15000-19000)	Inhibitor
Heparin calcium (MW 15000-19000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin.

HY-10787R

Ximelagatran (Standard)	Inhibitor
Ximelagatran (Standard) is the analytical standard of Ximelagatran (HY-10787). This product is intended for research and analytical applications. Ximelagatran (H 376/95) is an orally active thrombin inhibitor that selectively and competitively inhibits both free and clot-bound thrombin. Ximelagatran is an anticoagulant agent with a rapid onset of anticoagulant effect, predictable, dose-dependent pharmcoK_inetics and pharmacodynamics.

HY-77521R

Dabigatran (ethyl ester hydrochloride) (Standard)	Inhibitor
Dabigatran ethyl ester hydrochloride (Standard) is the analytical standard of Dabigatran ethyl ester hydrochloride (HY-77521). This product is intended for research and analytical applications. Dabigatran ethyl ester hydrochloride is a potent inhibitor of ribosyldihydronicotinamide dehydrogenase (NQO2) with an IC₅₀ value of 0.8 μM and a thrombin inhibitor.

HY-N13960

Bacithrocin D	Inhibitor
Bacithrocin D (Thiolstatin D) inhibits multiple proteases and can prolong the clotting time. Bacithrocin D has IC₅₀ values of 124, 9, 0.85, and 0.01 μM for thrombin, factor Xa, trypsin, and papain, respectively.

HY-117561

DuP 714	Inhibitor
DuP 714 is an oral active thrombin inhibitor with the IC₅₀ values of 150 nM aganist thrombin-induced aggregation in washed human platelets. DuP 714 can be used for study of arterial thrombosi.

HY-101918R

DS-1040 Tosylate (Standard)	Inhibitor
DS-1040 Tosylate (Standard) is the analytical standard of DS-1040 Tosylate (HY-101918). This product is intended for research and analytical applications. DS-1040 Tosylate is an orally active, selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC₅₀s of 5.92 nM and 8.01 nM for human and rat TAFIa. DS-1040 Tosylate is a fibrinolysis enhancer for thromboembolic diseases.

HY-117798

LY 806303	Inhibitor
LY 806303 is a potent and selective inhibitor of human α-thrombin. LY 806303 specifically acylates Ser-205 within the catalytic triad of α-thrombin on the heavy chain and a key site involved in the enzymatic activity of thrombin. The mechanism of action of LY 806303 as an enzyme inhibitor is through the specific acylation of this catalytic serine residue.

HY-B0375AR

Argatroban monohydrate (Standard)	Inhibitor
Argatroban (monohydrate) (Standard) is the analytical standard of Argatroban (monohydrate). This product is intended for research and analytical applications. Argatroban (monohydrate) (MD-805 (monohydrate)) is a direct, selective thrombin inhibitor.

HY-164251

RWJ-671818	Inhibitor
RWJ-671818 is an orally active inhibitor of human α-thrombin with a K_i of 1.3 nM. RWJ-671818 can be studied in research on venous and arterial thrombosis.

HY-136898

PS-915 dihydrochloride
PS-915 dihydrochloride is a peptide substrate used in a colorimetric assay for plasma antithrombin III (ATIII). PS-915 dihydrochloride is highly specific for thrombin. By enzyme hydrolysis, PS-915 dihydrochloride liberates 3-carboxy-4-hydroxyaniline (CHA), which turns blue in color due to the complex formation with added alkaline-pentacyanoammine ferroate.

HY-N13950

Bacithrocin A	Inhibitor
Bacithrocin A is a thrombin inhibitor that inhibits thrombin, factor Xa, trypsin and Papain with IC₅₀s of 48 μM, 13 μM, 0.65 μM, and 0.02 μM, respectively.

HY-10264BR

Edoxaban tosylate monohydrate (Standard)	Inhibitor
Edoxaban tosylate monohydrate (Standard) is the analytical standard of Edoxaban tosylate monohydrate (HY-10264B). This product is intended for research and analytical applications. Edoxaban (DU-176b) monohydrate is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Kis of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban monohydrate exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban monohydrate can be used for preventing thromboembolic disease research.

HY-12605S

SAR107375-d₁₁ Tartrate	Inhibitor
SAR107375-d₁₁ (Tartrate) is deuterium labeled SAR107375. SAR107375 is a potent and orally active dual thrombin and factor Xa inhibitor, with K_i values of 1 nM and 8 nM for factor Xa and thrombin, respectively.

HY-B0924R

Anisindione (Standard)	Inhibitor
Anisindione (Standard) is the analytical standard of Anisindione. This product is intended for research and analytical applications. Anisindione is an oral indandione anticoagulant. Anisindione inhibits the formation of active procoagulant factors II, VII, IX and X. Anisindione can be used in anticoagulation-related research.

HY-107023

AZD 9684	Inhibitor
AZD 9684 is a TAFIa inhibitor. AZD 9684 is applicable to research related to thrombosis and pulmonary embolism.

HY-122813

Dabigatran acyl-β-D-glucuronide	Inhibitor
Dabigatran acyl-β-D-glucuronide is an active metabolite of the thrombin inhibitor Dabigatran (HY-10163). Dabigatran acyl-β-D-glucuronide increases activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma.

HY-10274AR

Dabigatran etexilate mesylate (Standard)	Inhibitor
Dabigatran etexilate (mesylate) (Standard) is the analytical standard of Dabigatran etexilate (mesylate). This product is intended for research and analytical applications. Dabigatran etexilate mesylate (BIBR 1048MS) is an orally active proagent of Dabigatran (a direct inhibitor of thrombin). Dabigatran etexilate mesylate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation.

HY-10217R

Thrombin Inhibitor 2 (Standard)	Inhibitor
Thrombin Inhibitor 2 (Standard) is the analytical standard of Thrombin Inhibitor 2 (HY-10217). This product is intended for research and analytical applications. Thrombin Inhibitor 2 is a small molecule direct thrombin inhibitor, extracted from US8541580B2. Thrombin Inhibitor 2 has antithrombotic activity.

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Thrombin

Thrombin

Thrombin Related Products (222)

Antibodies (9)

Thrombin Related Products (222):