2. Metabolic Enzyme/Protease
  3. Thrombin
  4. YD-3

YD-3 is a platelet activation inhibitor. YD-3 inhibits Thrombine-induced rabbit platelets aggregation (IC50: 28.3 μM) and phosphoinositol production. In addition, YD-3 also inhibits Trypsin-induced platelet aggregation in human and rabbit with the IC50 of 38.1 μM and 5.7 μM, respectively, but does not affect the proteolytic activity of trypsin.

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YD-3

YD-3 Chemical Structure

CAS No. : 170632-41-4

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YD-3 Related Antibodies

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Description

YD-3 is a platelet activation inhibitor. YD-3 inhibits Thrombine-induced rabbit platelets aggregation (IC50: 28.3 μM) and phosphoinositol production. In addition, YD-3 also inhibits Trypsin-induced platelet aggregation in human and rabbit with the IC50 of 38.1 μM and 5.7 μM, respectively, but does not affect the proteolytic activity of trypsin[1].

Cellular Effect
Cell Line Type Value Description References
Platelet IC50
0.13 μM
Compound: YD-3
Inhibition of GYPGKF-induced human platelet aggregation
Inhibition of GYPGKF-induced human platelet aggregation
[PMID: 17988878]
Platelet IC50
164 μM
Compound: 11
Inhibition of PAF-induced platelet aggregation in human platelet-rich plasma incubated for 1 min followed by PAF addition
Inhibition of PAF-induced platelet aggregation in human platelet-rich plasma incubated for 1 min followed by PAF addition
[PMID: 33049608]
Platelet IC50
184.8 μM
Compound: 11
Inhibition of arachidonic acid-induced platelet aggregation in human platelet-rich plasma incubated for 1 min followed by arachidonic acid addition
Inhibition of arachidonic acid-induced platelet aggregation in human platelet-rich plasma incubated for 1 min followed by arachidonic acid addition
[PMID: 33049608]
Platelet IC50
212.4 μM
Compound: 11
Inhibition of collagen-induced platelet aggregation in human platelet-rich plasma incubated for 1 min followed by collagen addition
Inhibition of collagen-induced platelet aggregation in human platelet-rich plasma incubated for 1 min followed by collagen addition
[PMID: 33049608]
Platelet IC50
29.3 μM
Compound: 11
Inhibition of thrombin-induced platelet aggregation in human platelet-rich plasma incubated for 1 min followed by thrombin addition
Inhibition of thrombin-induced platelet aggregation in human platelet-rich plasma incubated for 1 min followed by thrombin addition
[PMID: 33049608]
Platelet IC50
> 10 μM
Compound: YD-3
Inhibition of SFLLRN-induced human platelet aggregation
Inhibition of SFLLRN-induced human platelet aggregation
[PMID: 17988878]
Platelet IC50
> 10 μM
Compound: YD-3
Inhibition of U46619-induced human platelet aggregation
Inhibition of U46619-induced human platelet aggregation
[PMID: 17988878]
Platelet IC50
> 10 μM
Compound: YD-3
Inhibition of collagen-induced human platelet aggregation
Inhibition of collagen-induced human platelet aggregation
[PMID: 17988878]
Platelet IC50
> 10 μM
Compound: YD-3
Inhibition of thrombin-induced human platelet aggregation
Inhibition of thrombin-induced human platelet aggregation
[PMID: 17988878]
Molecular Weight

356.42

Formula

C23H20N2O2
CAS No.
SMILES

O=C(OCC)C1=CC=C(C2=NN(CC3=CC=CC=C3)C4=C2C=CC=C4)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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YD-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YD-3170632-41-4YD3YD 3ThrombinInhibitorinhibitorinhibit

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