137171-40-5
137171-40-5
Chemical Structure
NAPAP
- CAS. Nr.: 137171-40-5
- Formula:C27H31N5O4S
- Molecular Weight:521.63
InChIKey: XXTWZTPVNIYSJZ-XMMPIXPASA-N
SMILES: N=C(N)C(C=C1)=CC=C1C[C@H](C(N2CCCCC2)=O)NC(CNS(=O)(C3=CC4=C(C=CC=C4)C=C3)=O)=O
Biological Activity: NAPAP is a selective direct thrombin inhibitor. NAPAP rapidly binds to thrombin and inhibits its activity, and reduces LPS (HY-D1056)-induced brain inflammation and coagulation factor expression in vivo. NAPAP can be used in studies related to coagulation and neuroinflammation[1][2][3].
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NAPAP | NAPAP is a selective direct thrombin inhibitor. NAPAP rapidly binds to thrombin and inhibits its activity, and reduces LPS (HY-D1056)-induced brain inflammation and coagulation factor expression in vivo. NAPAP can be used in studies related to coagulation and neuroinflammation. | |||||||||||||||||||||
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References
- [1]. Steinmetzer T, et al. Structure-activity relationships of new NAPAP-analogs. J Enzyme Inhib Med Chem. 2002;17(2):241-249. [Content Brief]
- [2]. Shavit Stein E, et al. Thrombin Inhibition Reduces the Expression of Brain Inflammation Markers upon Systemic LPS Treatment. Neural Plast. 2018;2018:7692182. Published 2018 Jun 19. [Content Brief]
- [3]. Ishikawa M, et al. Antidotal effect of lipopolysaccharide against acetaminophen-induced mortality in mice. Pharmacol Toxicol. 1990;67(5):387-391. [Content Brief]
