Thrombin
Thrombin is a Na+-activated, serine protease which is activated by the enzymatic cleavage of two sites on prothrombin by activated Factor X. Thrombin exists in two allosteric forms, slow (S) and fast (F), target toward anticoagulant and procoagulant activities.
Thrombin is the main effector protease in primary hemostasis by activating platelets and plays a key role in secondary hemostasis. Besides its well-known functions in hemostasis, thrombin also plays a role in various non-hemostatic biological and pathophysiologic processes, predominantly mediated through activation of protease-activated receptors (PARs). PAR-1, PAR-3, and PAR-4 are cleaved by thrombin, whereas PAR-2 is cleaved by trypsin. Thrombin also plays a crucial role in the migration and metastasis of human cancer cells.
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Thrombin Related Products (236)
Related Products (236)
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Antibodies (9)
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Neutrophil elastase-IN-7
0 ImagesNeutrophil elastase-IN-7 (Compound 12) is an effective inhibitor of neutrophil elastase (HNE), with an IC50 value of 0.54 μM. Neutrophil elastase-IN-7 also exhibits significant inhibitory activity against various coagulation proteins, with the IC50 values for thrombin, FXa, FXIa, and FXIIIa being 8.2, 12.7, 1.2, and 5.7 μM, respectively. Neutrophil elastase-IN-7 can be used for research on inflammation, innate immune responses, and tissue remodeling.
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Ainsliaeasin C
0 ImagesCat. No.: HY-N17623CAS No.: 1714097-11-6Ainsliaeasin C, a 7-hydroxycoumarin derivative, is an orally active anticoagulant agent that can be found in Ainsliaea fragrans. Ainsliaeasin C exerts anticoagulant activity both in vitro and in vivo. Ainsliaeasin C can be used for the research on thrombotic disorders.
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Efegatran dihydrochloride
0 ImagesCat. No.: HY-114603BCAS No.: 173006-83-2Synonyms: LY 294468 dihydrochlorideEfegatran (LY 294468) dihydrochloride is an inhibitor for thrombin, which inhibits aggregation of platelets, and exhibits anticoagulant and antithrombotic activities.
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Dabigatran-d7
0 ImagesCat. No.: HY-10163S5CAS No.: 2512224-24-5Synonyms: BIBR 953-d7; BIBR 953ZW-d7Dabigatran-d7 (BIBR 953-d7; BIBR 953ZW-d7) is the deuterium labeled Dabigatran (HY-10163). Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM).
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TFLLRNPNDK-NH2
0 ImagesCat. No.: HY-P5371CAS No.: 145229-90-9TFLLRNPNDK-NH2 is a biological active peptide. (This peptide is a thrombin receptor activating peptide. This PAR-1 agonist peptide reversibly binds to PAR-1 mimicking the 'tethered ligand' that thrombin makes available through proteolytic cleavage of substrate. It is also known to cause increase in liquid and protein permeability much like thrombin.)
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AZD6564
0 ImagesCat. No.: HY-12586CAS No.: 1251841-50-5AZD6564 is an orally active inhibitor for fibrinolysis through disruption of plasma kinase-fibrin interaction. AZD6564 dissolves human plasma clot with an IC50 of 0.44 μM. AZD6564 ameliorates hemorrhage in rats with EC50 of 1.62 μM, and exhibits good pharmacokinetic characteristics in rats.
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H-D-Phe-Pip-Arg-pNA dihydrochloride
0 ImagesCat. No.: HY-123275CCAS No.: 62354-65-8Synonyms: S-2238 dihydrochlorideH-D-Phe-Pip-Arg-pNA dihydrochloride (S-2238 dihydrochloride) is a specific chromogenic peptide substrate for thrombin (Thrombin). The amide bond of H-D-Phe-Pip-Arg-pNA dihydrochloride is rapidly hydrolyzed by thrombin, producing a characteristic yellow absorbance at 405 nm, and the change in absorbance is proportional to thrombin activity. H-D-Phe-Pip-Arg-pNA dihydrochloride can be used in biochemical detection-related studies.
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Z-Gly-Pro-Arg-4MβNA
0 ImagesCat. No.: HY-P4593CAS No.: 66647-41-4
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Dabigatran-13C,d3
0 ImagesCat. No.: HY-10163S3Synonyms: BIBR 953-13C,d3; BIBR 953ZW-13C,d3Dabigatran-13C,d3 is the 13C- and deuterium labeled Dabigatran. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM).
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Cbz-Lys-Arg-pNA
0 ImagesCat. No.: HY-P5027CAS No.: 108318-37-2Cbz-Lys-Arg-pNA is a peptide substrate containing pNA as the chromogenic group. Cbz-Lys-Arg-pNA is widely used in enzymatic analysis, including thrombin, plasmin, factor Xa and Kallikrein.
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Nonadecanoic acid-d3
0 ImagesCat. No.: HY-178398SNonadecanoic acid-d3 is the deuterium labeled Nonadecanoic acid (HY-W004261). Nonadecanoic acid is a 19-carbon long saturated fatty acid. Nonadecanoic acid is the major constituent of the substance secreted by Rhinotermes marginalis. Nonadecanoic acid can be isolated from several sources, including fungus, plant, and marine sponge. Nonadecanoic acid exhibits inhibitory effects on fibrinolysis and plasmin activity. Nonadecanoic acid produced from Streptomyces is an anti-tumor agent and inhibits IL-12 production.
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LY135305
0 ImagesCat. No.: HY-120563CAS No.: 123199-75-7LY 135305 is a thrombin activation inhibitor. LY 135305 inhibits spontaneous metastasis and increases animal survival.
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RWJ-445167
0 ImagesCat. No.: HY-19373CAS No.: 226566-43-4Synonyms: 3DP-10017
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Idrabiotaparinux sodium
0 ImagesCat. No.: HY-19442ACAS No.: 405159-59-3Idrabiotaparinux sodium is a derivative of Idraparinux synthesized with biotin. Idraparinux is a polymethylated synthetic pentasaccharide known to interact with the antithrombin III and act as anticoagulant.
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Metolazone-d7
0 ImagesSynonyms: SR-720-22-d7Metolazone-d7 is deuterium labeled Metolazone. Metolazone (SR-720-22) is primarily used to treat congestive heart failure and high blood pressure.
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(21S)-Argatroban
0 ImagesCat. No.: HY-116363ACAS No.: 121785-72-6(21S)-Argatroban is an isomer of Argatroban (HY-B0375) and is a thrombin inhibitor. (21S)-Argatroban can prolong blood clotting time, reduces platelet adhesion and aggregation.
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Anti-Antithrombin Antibody
0 ImagesCat. No.: HY-P991873
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FXIIa-IN-1 hydrochloride
0 ImagesCat. No.: HY-149396ACAS No.: 3052551-20-6FXIIa-IN-1 hydrochloride is the hydrochloride of FXIIa-IN-1 (HY-149396). FXIIa-IN-1 (Compound 22) is a Factor XIIa inhibitor (Kiapp: 97.8 nM). FXIIa-IN-1 can be used for research of thrombosis.
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Ro 09-1679
0 ImagesCat. No.: HY-125528CAS No.: 141426-89-3
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Nonadecanoic acid (Standard)
0 ImagesCat. No.: HY-W004261RCAS No.: 646-30-0Nonadecanoic acid (Standard) is the analytical standard of Nonadecanoic acid. This product is intended for research and analytical applications. Nonadecanoic acid is a 19-carbon long saturated fatty acid. Nonadecanoic acid is the major constituent of the substance secreted by Rhinotermes marginalis. Nonadecanoic acid can be isolated from several sources, including fungus, plant, and marine sponge. Nonadecanoic acid exhibits inhibitory effects on fibrinolysis and plasmin activity. Nonadecanoic acid produced from Streptomyces is an anti-tumor agent and inhibits IL-12 production.
