62354-65-8
Chemical Structure
H-D-Phe-Pip-Arg-pNA dihydrochloride
Synonym(s): S-2238 dihydrochloride
- CAS No.: 62354-65-8
- Formula:C27H38Cl2N8O5
- Molecular Weight:625.55
IUPAC Name: (S)-1-(D-phenylalanyl)-N-((S)-5-guanidino-1-((4-nitrophenyl)amino)-1-oxopentan-2-yl)piperidine-2-carboxamide dihydrochloride
InChIKey: NSXSTEARZJTALV-ROJHRYAJSA-N
SMILES: O=C([C@H](N)CC1=CC=CC=C1)N2[C@H](C(N[C@@H](CCCNC(N)=N)C(NC3=CC=C([N+]([O-])=O)C=C3)=O)=O)CCCC2.[H]Cl.[H]Cl
Biological Activity: H-D-Phe-Pip-Arg-pNA dihydrochloride (S-2238 dihydrochloride) is a specific chromogenic peptide substrate for thrombin (Thrombin). The amide bond of H-D-Phe-Pip-Arg-pNA dihydrochloride is rapidly hydrolyzed by thrombin, producing a characteristic yellow absorbance at 405 nm, and the change in absorbance is proportional to thrombin activity. H-D-Phe-Pip-Arg-pNA dihydrochloride can be used in biochemical detection-related studies[1][2].
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H-D-Phe-Pip-Arg-pNA dihydrochloride | H-D-Phe-Pip-Arg-pNA dihydrochloride (S-2238 dihydrochloride) is a specific chromogenic peptide substrate for thrombin (Thrombin). The amide bond of H-D-Phe-Pip-Arg-pNA dihydrochloride is rapidly hydrolyzed by thrombin, producing a characteristic yellow absorbance at 405 nm, and the change in absorbance is proportional to thrombin activity. H-D-Phe-Pip-Arg-pNA dihydrochloride can be used in biochemical detection-related studies. | |||||||||||||||||||||
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References
- [1]. Larsen M L, et al. Assay of plasma heparin using thrombin and the chromogenic substrate H-D-Phe-Pip-Arg-pNA (S-2238). Thrombosis Research, 1978, 13(2): 285-288.
- [2]. Nakajima N, et al. Characterization of potent fibrinolytic enzymes in earthworm, Lumbricus rubellus. Bioscience, biotechnology, and biochemistry. 1993 Oct;57(10):1726-30. [Content Brief]
