2. Signaling Pathways
  3. Neuronal Signaling
  4. OGT
  5. OGT Inhibitor

OGT Inhibitor

OGT Inhibitors (11):

Cat. No. Product Name Effect Purity
  • HY-119738
    OSMI-1
    		Inhibitor 99.88%
    OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC50 value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans.
  • HY-114361
    OSMI-4
    		Inhibitor 99.69%
    OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor, with an EC50 of 3 μM in cells.
  • HY-136282
    ST045849
    		Inhibitor 99.82%
    ST045849 (OGT-IN-2) is a small-molecule OGT inhibitor with an IC50 of 30 μM against sOGT and 53 μM against ncOGT. ST045849 is applicable to research on metabolism-related diseases.
  • HY-N3677
    Dammarenediol II
    		Inhibitor 99.81%
    Dammarenediol II is a ginsenoside precursor. Dammarenediol II reduces the activity of O-GlcNAc transferase (OGT) and downregulates the global O-GlcNAcylation level. Dammarenediol II inhibits the phosphorylation of Akt, mTOR and GSK3β. Dammarenediol II inhibits human carboxylesterase activity, VEGF-induced ROS production, stress fiber formation and vascular endothelial cadherin disruption. Dammarenediol II promotes cell apoptosis (apoptosis), increases the levels of cleaved PARP1 and p53, and inhibits retinal microvascular leakage. Dammarenediol II can be used in studies related to liver cancer and diabetic retinopathy.
  • HY-101548
    OGT-IN-1
    		Inhibitor 98.14%
    OGT-IN-1 (Compound 5) is a potent OGT inhibitor. OGT-IN-1 inhibits sOGT and ncOGT with IC50s of 27 and 10 μM, respectively.
  • HY-135784
    OSMI-2
    		Inhibitor 99.59%
    OSMI-2 (Compound 1b) is a cell-permeable O-linked N-acetylglucosamine transferase (OGT) inhibitor. Cells contain a large nuclear pool of partially spliced OGT transcript, and OSMI-2 increases detained intron splicing in cells.
  • HY-119738A
    (Rac)-OSMI-1
    		Inhibitor
    (Rac)-OSMI-1 is the racemate of OSMI-1. OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC50 value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans.
  • HY-125278
    OGT-IN-4
    		Inhibitor 99.65%
    OGT-IN-4 (compound 4a) is an O-GlcNAc transferase (OGT) inhibitor with a Kd of 8 nM. OGT-IN-4 can be utilized in OGT related research.
  • HY-135785
    OSMI-3
    		Inhibitor 99.08%
    OSMI-3 (Compound 2b) is a potent, long-lasting, and cell-permeable O-linked N-acetylglucosamine transferase (OGT) inhibitor. Cells contain a large nuclear pool of partially spliced OGT transcript, and OSMI-3 increases detained intron splicing in cells.
  • HY-149552
    Ac4-5SGlcNAc
    		Inhibitor
    Ac4-5SGlcNAc is an O-GlcNAc transferase (OGT) inhibitor. Ac4-5SGlcNAc converts intracellularly to UDP-5SGlcNAc, which competes with native UDP-GlcNAc (HY-148596) to block OGT catalytic activity, reduces cellular UDP-GlcNAc pools, and limits global protein O-GlcNAcylation. Ac4-5SGlcNAc reduces OGA levels via feedback, alters lectin signal intensities and glycan-related band masses. Ac4-5SGlcNAc can be used for the research of breast cancer.
  • HY-W477597
    BZX2
    		Inhibitor
    BZX2 is an irreversible covalent inhibitor of O-GlcNAc transferase (OGT) with an IC50 of <10 µM. BZX2 is cell-permeable but exhibits multiple off-target effects.