442665-87-4
442665-87-4
Chemical Structure
ST045849
Synonym(s): OGT-IN-2
- CAS No.: 442665-87-4
- Formula:C23H27ClN2O3S
- Molecular Weight:446.99
IUPAC Name: (Z)-3-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2-((4-chlorophenyl)imino)-4-oxo-1,3-thiazinane-6-carboxylic acid
InChIKey: HLPZEZRNGAXCJH-QLAUEMIBSA-N
SMILES: O=C(C1)N(/C(SC1C(O)=O)=N/C(C=C2)=CC=C2Cl)CCC3(C[C@H](C4)C5)C[C@H]5C[C@H]4C3
Biological Activity: ST045849 (OGT-IN-2) is a small-molecule OGT inhibitor with an IC50 of 30 μM against sOGT and 53 μM against ncOGT. ST045849 is applicable to research on metabolism-related diseases[1][2].
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ST045849 | 99.2% | ST045849 (OGT-IN-2) is a small-molecule OGT inhibitor with an IC50 of 30 μM against sOGT and 53 μM against ncOGT. ST045849 is applicable to research on metabolism-related diseases. | ||||||||||||||||||||
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References
- [1]. Bricelj A, et al. OSMI-4-based PROTACs do not influence O-GlcNAc transferase and O-GlcNAcylation levels in cells. RSC Adv. 2025;15(31):25717-25723. Published 2025 Jul 18. [Content Brief]
- [2]. Gross BJ, et al. Discovery of O-GlcNAc transferase inhibitors. J Am Chem Soc. 2005 Oct 26;127(42):14588-9. [Content Brief]
Keywords
