1-Adamantaneacetic acid
Based on 1 Customer Validation
1-Adamantaneacetic acid is an aliphatic carboxylic acid that can be used as an acylating agent, commonly found in chemical synthesis.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 4942-47-6
- Formula: C12H18O2
- Molecular Weight:194.27
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 4942-47-6
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Appearance Solid
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Molecular Weight 194.27
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Formula C12H18O2
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Color White to off-white
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SMILES
OC(CC12C[C@H]3C[C@@H](C2)C[C@@H](C1)C3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (514.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (25.74 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Sun X, et al. "One-Pot" Synthesis of γ-Pyrones from Aromatic Ketones/Heteroarenes and Carboxylic Acids. J Org Chem. 2020 Dec 4;85(23):15051-15061. [Content Brief]
[2]. Labudda-Dawidowska O, et al. New bradykinin analogues modified in the C-terminal part with sterically restricted 1-aminocyclohexane-1-carboxylic acid. J Med Chem. 2005 Dec 15;48(25):8055-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 5.1475 mL | 25.7374 mL | 51.4748 mL | 128.6869 mL |
| 5 mM | 1.0295 mL | 5.1475 mL | 10.2950 mL | 25.7374 mL | |
| 10 mM | 0.5147 mL | 2.5737 mL | 5.1475 mL | 12.8687 mL | |
| 15 mM | 0.3432 mL | 1.7158 mL | 3.4317 mL | 8.5791 mL | |
| 20 mM | 0.2574 mL | 1.2869 mL | 2.5737 mL | 6.4343 mL | |
| 25 mM | 0.2059 mL | 1.0295 mL | 2.0590 mL | 5.1475 mL | |
| 30 mM | 0.1716 mL | 0.8579 mL | 1.7158 mL | 4.2896 mL | |
| 40 mM | 0.1287 mL | 0.6434 mL | 1.2869 mL | 3.2172 mL | |
| 50 mM | 0.1029 mL | 0.5147 mL | 1.0295 mL | 2.5737 mL | |
| 60 mM | 0.0858 mL | 0.4290 mL | 0.8579 mL | 2.1448 mL | |
| 80 mM | 0.0643 mL | 0.3217 mL | 0.6434 mL | 1.6086 mL | |
| 100 mM | 0.0515 mL | 0.2574 mL | 0.5147 mL | 1.2869 mL |
1-Adamantaneacetic acid Related Classifications
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