14351-29-2
Chemical Structure
Dammarenediol II
- CAS No.: 14351-29-2
- Formula:C30H52O2
- Molecular Weight:444.73
IUPAC Name: (3S,5R,8R,9R,10R,13R,14R,17S)-17-((S)-2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-ol
InChIKey: NLHQJXWYMZLQJY-TXNIMPHESA-N
SMILES: C[C@@]1(CC[C@@]2([H])C3(C)C)[C@@](CC[C@@]4([H])[C@]1(CC[C@]4([H])[C@@](C)(O)CC/C=C(C)\C)C)([H])[C@]2(CC[C@@H]3O)C
Biological Activity: Dammarenediol II is a ginsenoside precursor. Dammarenediol II reduces the activity of O-GlcNAc transferase (OGT) and downregulates the global O-GlcNAcylation level. Dammarenediol II inhibits the phosphorylation of Akt, mTOR and GSK3β. Dammarenediol II inhibits human carboxylesterase activity, VEGF-induced ROS production, stress fiber formation and vascular endothelial cadherin disruption. Dammarenediol II promotes cell apoptosis (apoptosis), increases the levels of cleaved PARP1 and p53, and inhibits retinal microvascular leakage. Dammarenediol II can be used in studies related to liver cancer and diabetic retinopathy[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Dammarenediol II | 99.81% | Dammarenediol II is a ginsenoside precursor. Dammarenediol II reduces the activity of O-GlcNAc transferase (OGT) and downregulates the global O-GlcNAcylation level. Dammarenediol II inhibits the phosphorylation of Akt, mTOR and GSK3β. Dammarenediol II inhibits human carboxylesterase activity, VEGF-induced ROS production, stress fiber formation and vascular endothelial cadherin disruption. Dammarenediol II promotes cell apoptosis (apoptosis), increases the levels of cleaved PARP1 and p53, and inhibits retinal microvascular leakage. Dammarenediol II can be used in studies related to liver cancer and diabetic retinopathy. | ||||||||||||||||||||
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- [1]. Lee J, et al. Dammarenediol II enhances etoposide-induced apoptosis by targeting O-GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer. Mol Oncol. Published online December 30, 2025. [Content Brief]
- [2]. Kim SH, et al. Dammarenediol-II Prevents VEGF-Mediated Microvascular Permeability in Diabetic Mice. Phytother Res. 2015;29(12):1910-1916. [Content Brief]
Keywords
