2748153-92-4
Chemical Structure
(Rac)-OSMI-1
- CAS No.: 2748153-92-4
- Formula:C28H25N3O6S2
- Molecular Weight:563.64
IUPAC Name: N-(furan-2-ylmethyl)-2-(2-methoxyphenyl)-2-((2-oxo-1,2-dihydroquinoline)-6-sulfonamido)-N-(thiophen-2-ylmethyl)acetamide
InChIKey: IYIGLWQQAMROOF-UHFFFAOYSA-N
SMILES: O=C(N(CC1=CC=CS1)CC2=CC=CO2)C(NS(C3=CC(C=C4)=C(C=C3)NC4=O)(=O)=O)C5=CC=CC=C5OC
Biological Activity: (Rac)-OSMI-1 is the racemate of OSMI-1. OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC50 value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans[1][2].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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(Rac)-OSMI-1 | 96.51% | (Rac)-OSMI-1 is the racemate of OSMI-1. OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC50 value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans. | ||||||||||||||||||||
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-
Similarity Score 1.00
HY-119738OSMI-1 -
Similarity Score 0.78
HY-135784OSMI-2 -
Similarity Score 0.75
HY-148113PG 34 -
Similarity Score 0.69
HY-125278OGT-IN-4 -
Similarity Score 0.67
HY-114361OSMI-4 -
Similarity Score 0.67
HY-135785OSMI-3 -
Similarity Score 0.50
HY-183860Pefabloc PL -
Similarity Score 0.48
HY-181876F44-S101 -
Similarity Score 0.47
HY-107640WAY-170523 -
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References
- [1]. Ortiz-Meoz RF, et al. A small molecule that inhibits OGT activity in cells. ACS Chem Biol. 2015 Jun 19;10(6):1392-7. [Content Brief]
- [2]. Liu Y, et al. Discovery of a Low Toxicity O-GlcNAc Transferase (OGT) Inhibitor by Structure-based Virtual Screening of Natural Products. Sci Rep. 2017 Sep 26;7(1):12334. [Content Brief]
